Biological Strategies: Western Blot: TERF2IP Antibody [NB100-292] - Detection of Human RAP1 by Western Blot. Samples: Whole cell lysate (15 ug) from HeLa and 293T cells prepared using NETN lysis buffer. Antibody: ...read more
Immunohistochemistry: TERF2IP Antibody [NB100-292] - Samples: FFPE sections of human lung carcinoma.~~ Antibody: Affinity purified rabbit anti-RAP1 used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB
Independent Antibodies: Immunoprecipitation: TERF2IP Antibody [NB100-292] - Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibodies: ...read more
telomeric repeat binding factor 2, interacting protein
telomeric repeat-binding factor 2-interacting protein 1
TRF2-interacting telomeric protein 1
TRF2-interacting telomeric RAP1 protein
Mammalian telomeric proteins, including TRF1, TRF2, tankyrase, and TERF21P have no recognized orthologs in budding yeast. However, human Rap1 (hRap1) is an ortholog of the yeast telomeric protein, scRap1p. hRap1 is a homodimer, has three conserved sequence motifs in common with scRap1, is located at telomeres, and plays a role in telomere length regulation. Although scRap1 binds telomeric DNA directly, TERF21P is recruited to telomeres by TERF21P and binds it with its C-terminus, rather than directly binding DNA.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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