PGD2 Synthase/PTGDS Antibody

Images

 
Western Blot: PGD2 Synthase/PTGDS Antibody [NB110-59909] - Detection of Prostaglandin D Synthase/Lipocalin in human brain lysates (NB820-59177) using NB110-59909.
Simple Western: PGD2 Synthase/PTGDS Antibody [NB110-59909] - Simple Western lane view shows a specific band for PGD2/Synthase/PTGDS in 0.5 mg/ml of Human Brain lysate. This experiment was performed under reducing ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Eq, Fe, Fi, Pm, RbSpecies Glossary
Applications WB, Simple Western
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

PGD2 Synthase/PTGDS Antibody Summary

Immunogen
The epitope recognized by this antibody maps to region within residue 25-100 of human Prostaglandin D Synthase/Lipocalin. [Swiss-Prot# P41222]
Localization
Endoplasmic reticulum; rough endoplasmic reticulum. Nucleus; nuclear membrane. Golgi apparatus. Cytoplasm; perinuclear region. Secreted protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTGDS
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/ml
  • Simple Western 1:50
Application Notes
This Prostaglandin D Synthase/Lipocalin antibody is useful for Western blot analysis where a band can be seen at approx. 21 kDa.

In Simple Western only 10 - 15 uL of the recommended dilution is used per data point. Separated by Size-Wes, Sally Sue/Peggy Sue.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
21 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control
Human Brain Whole Tissue Lysate (Adult Whole Normal)
PGD2 Synthase/PTGDS Overexpression Lysate
Control Peptide
PGD2 Synthase/PTGDS Peptide (NB110-59909PEP)
Publications
Read Publications using
NB110-59909 in the following applications:

  • WB
    2 publications

Reactivity Notes

Fish reactivity reported in scientific literature (PMID: 31401171).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS and 30% Glycerol
Preservative
0.1% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PGD2 Synthase/PTGDS Antibody

  • Beta-trace protein
  • Cerebrin-28
  • EC 5.3.99.2
  • Glutathione-independent PGD synthase
  • glutathione-independent PGD synthetase
  • lipocalin-type prostaglandin D synthase
  • Lipocalin-type prostaglandin-D synthase
  • L-PGDS
  • PDS
  • PGD2 Synthase
  • PGD2
  • PGDS2
  • PGDSLPGDS
  • PH2DISO
  • prostaglandin D synthase
  • prostaglandin D2 synthase (21kD, brain)
  • prostaglandin D2 synthase 21kDa (brain)
  • Prostaglandin-D2 synthase
  • prostaglandin-H2 D-isomerase
  • PTGDS

Background

Prostaglandin D Synthase/Lipocalin (L-PGDS) is a brain-derived protein found most abundantly in CSF and it induces neuronal cell protection and neuronal cell loss, depending on the receptor pathway it signals to the target cells. L-PGDS is found secreted as well as localized to RER, nuclear membrane, Golgi apparatus, perinuclear cytoplasm etc and has been detected in arachnoid and menigioma cells, arachnoid trabecular cells, meningeal macrophages and perivascular microglial cells, oligodendrocytes as well as RPE cells. L-PGDS catalyzes the metabolic transformation of PGH2 to PGD2, a prostaglandin implicated in smooth muscle contraction/relaxation and a platelet aggregation inhibitor. It is implicated in several CNS functions including sedation, NREM sleep and PGE2-induced allodynia, and plays anti-apoptotic role in oligodendrocytes. L-PGDS can bind to small non-substrate lipophilic molecules such as biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. L-PGDS has also been suggested to play role in development and maintenance of blood-brain, blood-retina, blood-aqueous humor and blood-testis barriers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu, Mu, Rt, Po, Bv, Eq, Fe, Fi, Pm, Rb
Applications: WB, Simple Western

Publications for PGD2 Synthase/PTGDS Antibody (NB110-59909)(2)

We have publications tested in 2 confirmed species: Human, Fish.

We have publications tested in 1 application: WB.


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WB
(2)
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Human
(1)
Fish
(1)
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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for PGD2 Synthase/PTGDS Antibody (NB110-59909) (0)

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB110-59909AF350
Alexa Fluor 405 NB110-59909AF405
Alexa Fluor 488 NB110-59909AF488
Alexa Fluor 532 NB110-59909AF532
Alexa Fluor 594 NB110-59909AF594
Alexa Fluor 647 NB110-59909AF647
Alexa Fluor 700 NB110-59909AF700
Alexa Fluor 750 NB110-59909AF750
Biotin NB110-59909B
DyLight 350 NB110-59909UV
DyLight 405 NB110-59909V
DyLight 488 NB110-59909G
DyLight 550 NB110-59909R
DyLight 594 NB110-59909DL594
DyLight 650 NB110-59909C
DyLight 680 NB110-59909FR
DyLight 755 NB110-59909IR
HRP NB110-59909H
Janelia Fluor 549 NB110-59909JF549
Janelia Fluor 646 NB110-59909JF646

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Bioinformatics

Gene Symbol PTGDS