PGD2 Synthase/PTGDS Antibody


Western Blot: PGD2 Synthase/PTGDS Antibody [NB110-59909] - Detection of Prostaglandin D Synthase/Lipocalin in human brain lysates (NB820-59177) using NB110-59909.
Simple Western: PGD2 Synthase/PTGDS Antibody [NB110-59909] - Simple Western lane view shows a specific band for PGD2/Synthase/PTGDS in 0.5 mg/ml of Human Brain lysate. This experiment was performed under reducing more

Product Details

Reactivity Hu, Mu, Rt, Po, Bv, Eq, Fe, Pm, RbSpecies Glossary
Applications WB, Simple Western
1 mg/ml

PGD2 Synthase/PTGDS Antibody Summary

The epitope recognized by this antibody maps to region within residue 25-100 of human Prostaglandin D Synthase/Lipocalin. [Swiss-Prot# P41222]
Endoplasmic reticulum; rough endoplasmic reticulum. Nucleus; nuclear membrane. Golgi apparatus. Cytoplasm; perinuclear region. Secreted protein.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS, 30% glycerol
0.1% Sodium Azide
1 mg/ml
Immunogen affinity purified


Application Notes
This Prostaglandin D Synthase/Lipocalin antibody is useful for Western blot analysis where a band can be seen at ~21 kDa.In Simple Western only 10-15 uL of the recommended dilution is used per data point. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
21 kDa
Control Peptide
PGD2 Synthase/PTGDS Peptide (NB110-59909PEP)
Read Publication using
NB110-59909 in the following applications:

  • WB
    1 publication

Reactivity Notes

Immunogen sequence has 87% homology to sheep and 82% homology to rabbit.

Alternate Names for PGD2 Synthase/PTGDS Antibody

  • Beta-trace protein
  • Cerebrin-28
  • EC
  • Glutathione-independent PGD synthase
  • glutathione-independent PGD synthetase
  • lipocalin-type prostaglandin D synthase
  • Lipocalin-type prostaglandin-D synthase
  • L-PGDS
  • PDS
  • PGD2 synthase
  • PGD2
  • PGDS2
  • prostaglandin D synthase
  • prostaglandin D2 synthase (21kD, brain)
  • prostaglandin D2 synthase 21kDa (brain)
  • Prostaglandin-D2 synthase
  • prostaglandin-H2 D-isomerase


Prostaglandin D Synthase/Lipocalin (L-PGDS) is a brain-derived protein found most abundantly in CSF and it induces neuronal cell protection and neuronal cell loss, depending on the receptor pathway it signals to the target cells. L-PGDS is found secreted as well as localized to RER, nuclear membrane, Golgi apparatus, perinuclear cytoplasm etc and has been detected in arachnoid and menigioma cells, arachnoid trabecular cells, meningeal macrophages and perivascular microglial cells, oligodendrocytes as well as RPE cells. L-PGDS catalyzes the metabolic transformation of PGH2 to PGD2, a prostaglandin implicated in smooth muscle contraction/relaxation and a platelet aggregation inhibitor. It is implicated in several CNS functions including sedation, NREM sleep and PGE2-induced allodynia, and plays anti-apoptotic role in oligodendrocytes. L-PGDS can bind to small non-substrate lipophilic molecules such as biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. L-PGDS has also been suggested to play role in development and maintenance of blood-brain, blood-retina, blood-aqueous humor and blood-testis barriers.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PGD2 Synthase/PTGDS Antibody (NB110-59909)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB110-59909AF405
Alexa Fluor (R) 488 Labeled NB110-59909AF488
Alexa Fluor (R) 647 Labeled NB110-59909AF647
Alexa Fluor (R) 700 Labeled NB110-59909AF700
Biotin Labeled NB110-59909B
DyLight 405 Labeled NB110-59909V
DyLight 488 Labeled NB110-59909G
DyLight 550 Labeled NB110-59909R
DyLight 650 Labeled NB110-59909C
FITC Labeled NB110-59909F
HRP Labeled NB110-59909H

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Product PDFs


Gene Symbol PTGDS

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