PGD2 Synthase/PTGDS Products

Description

Prostaglandin D Synthase (PTGDS), is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of amyloid-b plaques in Alzheimer's disease.

Bioinformatics

Entrez	19215 Mouse 25526 Rat 5730 Human
Uniprot	AAH05939 Human B2R727 Human NM_000954 Human NP_000945.3 Human P41222 Human
Product By Gene ID	5730
Alternate Names	Beta-trace protein cerebrin-28 Cerebrin-28 EC 5.3.99.2 Glutathione-independent PGD synthase glutathione-independent PGD synthetase lipocalin-type prostaglandin D synthase Lipocalin-type prostaglandin-D synthase L-PGDS PDS PGD2 synthase PGD2 PGDS2 PGDSLPGDS prostaglandin D synthase prostaglandin D2 synthase (21kD, brain) prostaglandin D2 synthase 21kDa (brain) Prostaglandin-D2 synthase prostaglandin-H2 D-isomerase

Research Areas for PGD2 Synthase/PTGDS

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