PDGFR alpha Antibody - BSA Free

Immunocytochemistry/Immunofluorescence: PDGF R alpha Antibody [NBP2-76508] - Staining of human cell line CACO-2 shows localization to nucleoplasm, plasma membrane & cell junctions. Antibody staining is shown in green.

• Reactivity: Hu
• Applications: Flow, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

PDGFR alpha Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit PDGFR alpha Antibody - BSA Free (NBP2-76508) is a polyclonal antibody validated for use in Flow and ICC/IF. Anti-PDGFR alpha Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: EVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PDGFRA
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry Reported in scientific literature (PMID:35320046)
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
• Application Notes: ICC/IF,Fixation Permeabilization: Use PFA/Triton X-100..

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for PDGFR alpha Antibody - BSA Free

• alpha-type platelet-derived growth factor receptor
• CD140 antigen-like family member A
• CD140a antigen
• CD140a
• EC 2.7.10
• EC 2.7.10.1
• MGC74795
• PDGF R alpha
• PDGFR alpha
• PDGFR2
• PDGFRA
• PDGFRA/BCR fusion
• PDGF-R-alpha
• platelet-derived growth factor receptor, alpha polypeptide
• rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein
• RHEPDGFRA

Background

Platelet-derived growth factor receptors exhibit tyrosine-protein kinase activity and have been implicated in the control of cell proliferation, survival and migration. PDGF receptors, PDGFR-alpha and PDGFR-beta, have 5 extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo-and heterodimers. Dimerization of the receptors results in phosphorylation in the complex. More than 10 different SH2-domain-containing molecules have been shown to bind to different autophosphorylation sites in the PDGF-alpha and beta receptors. PDGF alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are expressed on neurons.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PDGFR alpha Antibody (NBP2-76508)(1)

Publication using NBP2-76508

• Layton TB, Williams L, Yang N et al. A vasculature niche orchestrates stromal cell phenotype through PDGF signaling: Importance in human fibrotic disease Proceedings of the National Academy of Sciences of the United States of America 2022-03-29 [PMID: 35320046] (FLOW, Human)

Bioinformatics

• Gene Symbol: PDGFRA