PARL Antibody

Images

 
Western Blot: PARL Antibody [NBP1-76938] - 3T3 cell lysate with PARL antibody at (A) 1 and (B) 2 ug/ml.
Immunocytochemistry/ Immunofluorescence: PARL Antibody [NBP1-76938] - Immunofluorescence of PARL in 3T3 cells with PARL antibody at 2.50 ug/mL.
Immunocytochemistry/ Immunofluorescence: PARL Antibody [NBP1-76938] - 3T3 cells with PARL antibody at 2.5 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

PARL Antibody Summary

Immunogen
Antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human PARL. The immunogen is located within amino acids 40 - 90 of PARL.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PARL
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 2.5 ug/ml
Control Peptide
PARL Peptide (NBP1-76938PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PARL Antibody

  • EC 3.4.21.105
  • mitochondrial
  • PARL
  • presenilin associated, rhomboid-like
  • PRO2207
  • PSARL1
  • RHBDS1
  • rhomboid 7 homolog 1

Background

PARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins. PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1, a protein that prevents the release of cytochrome C from the mitochondria in response to apoptotic signals. In lymphocytes and neurons, PARL's association with other proteins, such as the Bcl-2 family-related protein Hax1 and Omi can lead to the proteolytic processing of Omi by PARL, preventing the accumulation of Bax, thereby suppressing apoptosis. Variations in this gene have been associated with increased risk for type 2 diabetes. PARL may also play a role in the progression of Alzheimer's disease through its associations with presenilin-1 and -2. Despite its predicted molecular weight of ~42kDa, PARL is observed at a higher molecular weight in SDS-PAGE. Multiple isoforms of PARL are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PARL
Entrez
Uniprot