Mitofusin 1 Antibody (11E9-1H12)


Western Blot: Mitofusin 1 Antibody (11E9-1H12) [NBP1-71775] - Analysis of Mitofusin-1 expression in 1) MEF wild-type and 2) MEF Mitofusin-1-null whole cell lysates using NBP1-71775.
Immunocytochemistry/ Immunofluorescence: Mitofusin 1 Antibody (11E9-1H12) [NBP1-71775] - Mitofusin 1 antibody was tested in 3T3 cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI more
Immunohistochemistry-Paraffin: Mitofusin 1 Antibody (11E9-1H12) [NBP1-71775] - Analysis of Mitofusin-1 in mouse liver.

Product Details

Reactivity Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
1 mg/ml

Mitofusin 1 Antibody (11E9-1H12) Summary

Mouse Mitofusin-1 [Swiss-Prot# Q811U4]
Mitochondrion outer membrane; Multi-pass membrane protein
Mitochondrial Fusion Marker
IgG2b Kappa
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1 mg/ml
Protein G purified


Application Notes
This Mitofusin-1 (11E9-1H12) antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections and Western blot, where a band can be seen at ~80 kDa. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
80 kDa
Read Publications using
NBP1-71775 in the following applications:

  • WB
    7 publications

Reactivity Notes

Mouse. Rat reactivity reported in scientific literature (PMID: 23658809).

Alternate Names for Mitofusin 1 Antibody (11E9-1H12)

  • DKFZp762F247
  • EC 3.6.5
  • EC 3.6.5.-
  • FLJ20693
  • Fzo homolog
  • hfzo1
  • hfzo2
  • MFN1
  • MGC41806
  • mitochondrial transmembrane GTPase Fzo-1
  • mitochondrial transmembrane GTPase FZO-2
  • mitofusin 1
  • mitofusin-1
  • putative transmembrane GTPase
  • Transmembrane GTPase MFN1


Mitochondria are dynamic organelles that continuously divide and fuse, and their dynamics/distribution is critical for their role in bioenergetics and cell survival. Mitochondrial fusion process is mediated by mitofusin 1 (MFN1) and mitofusin 2 (MFN2) proteins in the outer membrane as well as OPA1 in the inner mitochondrial membrane. MFN1 is an essential transmembrane GTPase critical to mitochondrial fusion; acts independently of the cytoskeleton, and its overexpression induces formation of mitochondrial networks. MFN1 forms homo-/-heteromultimers (with MFN2), and the multimerization has been proposed to be essential for mitochondrion fusion. MFN1 interacts with VAT1 and is ubiquitinated by MARCH5. A mutation in the GTPase domain disrupts the mitochondrial fusion activity of MFN1/MFN2 and loss of MFN1/2 leads to mitochondrial dysfunction mediated embryonic lethality in mice. MFN proteins have been reported to regulate mitochondrial membrane potential, while silencing of MFN1/2 resulte in mitochondrial fragmentation and increased apoptotic sensitivity.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Mitofusin 1 Antibody (NBP1-71775)(7)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 1 application: WB.

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Showing Publications 1 - 7 of 7.
Publications using NBP1-71775 Applications Species
Montaigne D, Marechal X, Coisne A et al. Myocardial Contractile Dysfunction is Associated with Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but not in Obese Patients. Circulation. 2014 Jun 13 [PMID:24928681] (WB, Human) WB Human
Wu Z, Zhu Y, Cao X et al. Mitochondrial Toxic Effects of Abeta Through Mitofusins in the Early Pathogenesis of Alzheimer's Disease. Mol. Neurobiol. 2014 Apr 08 [PMID:24710686] (WB, Human) WB Human
Amadoro G, Corsetti V, Florenzano F et al. AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons. Neurobiol. Dis. 2014 Feb 1 [PMID:24411077] (WB, Rat) WB Rat
Wappler EA, Institoris A, Dutta S et al. Mitochondrial Dynamics Associated with Oxygen-Glucose Deprivation in Rat Primary Neuronal Cultures. PLoS One 2013 May 2 [PMID:23658809] (WB, Rat) WB Rat
White JP, Puppa MJ, Sato S et al. IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse Skelet Muscle 2012 Jul 6 [PMID:22769563] (WB, Mouse) WB Mouse
Trushina E, Nemutlu E, Zhang S et al. Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease PLoS ONE 2012 [PMID:22393443] (WB, Mouse) WB Mouse
Xu YF, Gendron TF, Zhang YJ et al. Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice J Neurosci 2010 Aug 11 [PMID:20702714] (WB, Mouse) WB Mouse

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Mitofusin 1 Antibody (NBP1-71775). (Showing 1 - 1 of 1 FAQs).

  1. Could you please tell me if you'd offer the mitofusin 1 antibody Cat# NBP1-71775 for using it with rat tissue? If not, could you please offer one that works with rats?
    • NBP1-71775 has been validated for use in human and mouse only. Rat is not one of the listed species and we cannot guarantee that it will work in rat. Unfortunately, we currently do not have a Mitofusin-1 antibody that has been tested and validated for use in rat. If you'd be interested in testing one of our antibodies, we can recommend our Innovator's Reward program. Our Innovator's Reward is offered to reward researchers for testing new species and applications with our products. If testing on this antibody is performed on an untested species and/or application, and the results are shared, then the antibody is eligible for the nnovator's Reward. Under this program, Novus will provide you a credit of equal or lesser value on a future product of equal value in exchange for your new data in the form of an online review. The great thing is you are eligible even if the antibody doesn't work because the data is still useful to us. (Note: Rat was added as a species on the datasheet from a researcher who published using rat in May 2013 - please see PMID 23658809 for details).

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NBP1-71775AF405
Alexa Fluor (R) 488 Labeled NBP1-71775AF488
Alexa Fluor (R) 647 Labeled NBP1-71775AF647
Alexa Fluor (R) 700 Labeled NBP1-71775AF700
Allophycocyanin Labeled NBP1-71775APC
Biotin Labeled NBP1-71775B
DyLight 350 Labeled NBP1-71775UV
DyLight 405 Labeled NBP1-71775V
DyLight 405LS Labeled NBP1-71775V3
DyLight 488 Labeled NBP1-71775G
DyLight 550 Labeled NBP1-71775R
DyLight 650 Labeled NBP1-71775C
DyLight 680 Labeled NBP1-71775FR
DyLight 755 Labeled NBP1-71775IR
FITC Labeled NBP1-71775F
HRP Labeled NBP1-71775H
PE Labeled NBP1-71775PE
PerCP Labeled NBP1-71775PCP

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Contact Information

Product PDFs


Gene Symbol MFN1

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