PARL Products

Description

PARL encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Bioinformatics

Uniprot	NM_018622 Human NP_061092 Human NP_061092.3 Human Q9H300 Human
Product By Gene ID	55486
Alternate Names	EC 3.4.21.105 mitochondrial presenilin associated, rhomboid-like PRO2207 rhomboid 7 homolog 1

Diseases related to PARL

Discover more about diseases related to PARL.

Parkinson Disease
Optic Atrophy
Atrophy
Insulin Resistance
Optic Atrophy, Autosomal Dominant
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Plant Diseases
Nerve Degeneration
Glaucoma, Open-angle
Glaucoma
Blind Vision
Neurodegenerative Disorders
Disorder Of The Optic Nerve
Optic Atrophy, Hereditary, Leber
Cholangiocarcinoma
Malnutrition
Diabetic Nephropathy
Malignant Neoplasm Of Breast

Pathways for PARL

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Proteolysis
Cell Death
Mitochondrial Fusion
Pathogenesis
Transport
Programmed Cell Death
Aging
Photosynthesis
Oxidative Phosphorylation
Fermentation
Lactation
Membrane Fusion
Localization
Germination
Cell Adhesion
Quorum Sensing
Electron Transport
Electron Transport Chain
Regulation Of Cytoskeleton
Regulation Of Mitochondrial Fusion

Research Areas for PARL

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Alzheimers Research
Apoptosis
Mitochondrial Fusion Proteins
Neuroscience

PTMs for PARL

Learn more about PTMs related to PARL.

Cleavage
Phosphorylation
Oxidation

Bioinformatics Tool for PARL

Discover related pathways, diseases and genes to PARL. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.