OSCAR Antibody

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

OSCAR Antibody Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse OSCAR
  Asp19-Asn228
  Accession # Q8VBT3
• Specificity: Detects mouse OSCAR in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: OSCAR
• Purity: Immunogen affinity purified
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Immunogen affinity purified
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for OSCAR Antibody

• hOSCAR
• MGC33613
• OSCAR
• osteoclast associated receptor OSCAR-S1
• osteoclast associated receptor OSCAR-S2
• osteoclast associated, immunoglobulin-like receptor
• osteoclast-associated immunoglobulin-like receptor
• Osteoclast-associated receptor
• PIGR3
• PIgR-3
• Poly-Ig receptor 3
• Polymeric immunoglobulin receptor 3

Background

OSCAR is a type I transmembrane protein that may be a bone-specific regulator of osteoclast differentiation. It contains two extracellular Ig-like domains that share homology with mouse PIR (Paired immunoglobulin-like receptor) family proteins and members of the human Leukocyte Receptor Complex (LRC)-encoded proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for OSCAR Antibody (AF1633)(3)

Publications using AF1633

• Y Chen, B Wei, P Xu, H Tang, L Yang, Y Wang, Y Fu, X Yang, Y Mao Schistosoma�japonicum cystatin suppresses osteoclastogenesis via manipulating the NF?&kappaB signaling pathway Molecular Medicine Reports, 2021;23(4):. 2021-01-01 [PMID: 33576450] (Western Blot, Mouse)
• HS Kim, ST Nam, SH Mun, SK Lee, HW Kim, YH Park, B Kim, KJ Won, HR Kim, YM Park, HS Kim, MA Beaven, YM Kim, WS Choi DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation Nat Commun, 2017;8(1):1519. 2017-01-01 [PMID: 29142196] (Western Blot, Mouse)
• Jang HD, Shin JH, Park DR, Hong JH, Yoon K, Ko R, Ko CY, Kim HS, Jeong D, Kim N, Lee SY Inactivation of glycogen synthase kinase-3beta is required for osteoclast differentiation. J. Biol. Chem., 2011;286(45):39043-50. 2011-01-01 [PMID: 21949120] (Western Blot, Mouse)

Bioinformatics

• Gene Symbol: OSCAR
• Uniprot:
  • Q8VBT3()