NOD1 Antibody (626919) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 626919
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

NOD1 Antibody (626919) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human NOD1
  Lys830-Phe953
  Accession # Q9Y239
• Specificity: Detects human NOD1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human NOD2 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NOD1 Antibody (626919) [Alexa Fluor® 488]

• CARD4
• CARD4NLR family, CARD domain containing 1
• caspase recruitment domain family, member 4
• Caspase recruitment domain-containing protein 4
• CLR7.1
• NLRC1
• NOD1
• nucleotide-binding oligomerization domain containing 1
• nucleotide-binding oligomerization domain, leucine rich repeat and CARD domaincontaining 1
• nucleotide-binding oligomerization domain-containing protein 1

Background

NOD1, also called CARD4, is a 108 kDa intracellular pattern recognition receptor of the Nod-like receptor (NLR or Caterpiller) family. This innate immune receptor recognizes the muramyl peptide, diaminopimelic acid. The 953 amino acid (aa) NOD1 contains a caspase recognition domain (CARD), an NTPase domain and 10 leucine‑rich repeats (LRR). Splicing variants of 925 and 779 aa lack all or part of LRR 7-10 and do not respond to muramyl peptides. Polymorphisms of NOD1 are associated with inflammatory bowel disease. Within aa 830-953 (LRR 7-110), human NOD1 shares 82% and 84% aa identity with mouse and rat NOD1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.