NOD1 Products

Antibodies
NOD1 Antibody
NOD1 Antibody
NB100-56152
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
NOD1 Antibody
NOD1 Antibody
NB100-56878
Species: Hu
Applications: WB, IHC-P
Host: Rabbit Polyclonal
NOD1 Antibody
NOD1 Antibody
NBP1-76286
Species: Hu, Mu, Rt
Applications: WB, ELISA, Flow
Host: Rabbit Polyclonal
Lysates
NOD1 Overexpression Lysate (D ...
NOD1 Overexpression Lysate (Denatu...
H00010392-T01
Species: Hu
Applications: WB
NOD1 Overexpression Lysate (N ...
NOD1 Overexpression Lysate (Native)
NBL1-13705
Applications: WB
Proteins
Recombinant Human NOD1 Protei ...
Recombinant Human NOD1 Protein
H00010392-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human NOD1 Protei ...
Recombinant Human NOD1 Protein
H00010392-Q01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human NOD1 Protei ...
Recombinant Human NOD1 Protein
H00010392-Q02
Species: Hu
Applications: WB, ELISA, PA
RNAi
NOD1 RNAi
NOD1 RNAi
H00010392-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Innate immunity is present in all animals and is the common mode of defense against microorganisms. It detects microorganisms by specific proteins called pattern-recognition molecules (PRMs) (reviewed in Werts et al. 2006). There is a limited set of PRMs in each animal genome, and it has been postulated that the PRMs were evolutionarily selected to detect conserved components or motifs of microorganisms called pathogen-associated molecular patterns (PAMPs). PAMPs are found in a wide range of microorganisms and recognition of PAMPs by PRMs activates inflammatory signaling pathways, thereby stimulating an immune response. NOD (nucleotide-binding oligomerization domain) proteins are a family of cytosolic proteins which have been implicated in innate recognition of bacteria, the induction of inflammatory responses, and the regulation of caspase activation and apoptosis. NOD1/CARD4 (caspase-recruitment domain 4 gene) is a PRM that recognizes specific peptidoglycan (PGN) components of bacterial cell walls (reviewed in Strober et al. 2006, and Inohara et al. 2003). NOD1 is expressed by cell types that are exposed to PGN under physiological conditions including antigen-presenting cells (APCs) such as macrophages and dendritic cells, and epithelial cells (reviewed in Strober et al. 2006). NOD1 is thought to play a role in the pathogenesis of human gastrointestinal disease and is associated with inflammatory bowel diseases and asthma. It is involved in host defense against Helicobacter pylori infection of the gastric mucosa, a chronic infection that can lead to peptic ulcers and gastric cancer. This antibody recognizes NOD1/CARD4. Human NOD1/CARD4 is a 953 amino acid protein.

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 10392
Alternate Names
  • caspase recruitment domain family, member 4
  • nucleotide-binding oligomerization domain-containing protein 1
  • NLRC1
  • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domaincontaining 1
  • CLR7.1
  • CARD4NLR family, CARD domain containing 1
  • Caspase recruitment domain-containing protein 4
  • nucleotide-binding oligomerization domain containing 1

Research Areas for NOD1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Asthma
Autophagy
Immunology

Bioinformatics Tool for NOD1

Discover related pathways, diseases and genes to NOD1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related NOD1 Blog Posts

Check out the latest blog posts on NOD1.
cIAP2 - balancing cell death and cell survival
The inhibitor of apoptosis proteins (IAPs) are important regulators of cell death and inflammation. The cellular inhibitor of apoptosis protein 2 (cIAP2) contains three Baculovirus IAP repeat (BIR) domains, a Ubiquitin associated (UBA) domain, and...    Read more.
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