NLRP10/Pynod/NALP10 Antibody

Western Blot: NLRP10/Pynod/NALP10 Antibody [NBP2-24606] - Analysis of NALP10 in HeLa cell lysate in the 1) absence and 2) presence of immunizing peptide and 3) RAW cell lysate using NBP2-24606 at 1.0 ug/ml.

• Reactivity: Hu, Mu, Rb
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

NLRP10/Pynod/NALP10 Antibody Summary

• Description: Novus Biologicals Rabbit NLRP10/Pynod/NALP10 Antibody (NBP2-24606) is a polyclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: A portion of amino acids 493-509 of human NALP10 REVQRLLEVKEQEGNDE protein was used as the immunogen.
• Predicted Species: Rabbit (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NLRP10
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1.0-2.0 ug/ml

Reactivity Notes

The amino acid sequence used as immunogen is 95% homologous in rabbit and 86% homologous in mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS and 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein A purified

Alternate Names for NLRP10/Pynod/NALP10 Antibody

• CLR11.1
• NACHT, leucine rich repeat and PYD containing 10
• NALP10
• NALP10Pynod
• NLR family, pyrin domain containing 10
• NLRP10
• NOD8
• NOD8Nucleotide-binding oligomerization domain protein 8
• nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 10
• PAN5
• Pynod
• PYNODNACHT, LRR and PYD domains-containing protein 10

Background

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminalleucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs tothe NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innateimmune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates thepro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as amultifunctional negative regulator of inflammation and apoptosis. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NLRP10
• Uniprot:
  • Q86W26()