Viral reactivity reported in scientific literature (PMID: 31367214).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
Peptide affinity purified
Alternate Names for NALP12 Antibody
NACHT, leucine rich repeat and PYD containing 12
NACHT, LRR and PYD domains-containing protein 12
NALP12LRR and PYD containing protein 12
NLR family, pyrin domain containing 12
nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 12
PYRIN-containing APAF1-like protein 7
Regulated by nitric oxide
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappaB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for NALP12 Antibody (NBP1-76293). (Showing 1 - 1 of 1 FAQ).
Actually i'm testing the mouse monoclonal anti-hNLRP12, but as in the image that you show for the rabbit policlonal anti-hNLRP12, i just see a band in the 95 kDa region, so i would like to know why the antibody doesn't recognize a band at aprox 120 kDa, do you know about a postranscriptional modification of this protein??
There are several different characterized isoform of NALP12. Please visit the following website to learn more, UniProt P59046. The band that you see in our western blot reflects the NALP12 isoform expressed in the tissue probed, and it may vary between different tissues and species.
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Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.