SOCS-1 Antibody


Western Blot: SOCS-1 Antibody [NB100-781] - (mock transfection in lane B).
Immunohistochemistry-Paraffin: SOCS-1 Antibody [NB100-781] - (2.5ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. This data is from a previous batch.
Western Blot: SOCS-1 Antibody [NB100-781] - Staining (2ug/ml) of mouse spleen lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P, PEP-ELISA
0.5 mg/ml

Order Details

SOCS-1 Antibody Summary

Peptide with sequence C-VLRDYLSSFPFQI corresponding to C-Terminus according to NP_003736.1.
Immunogen affinity purified
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  • Western Blot 1-3 ug/ml
  • Immunohistochemistry 2 - 3 ug/ml
  • Immunohistochemistry-Paraffin 2-3 ug/ml
  • Peptide ELISA detection limit 1:32000
Application Notes
WB: In transfected HEK293 transiently expressing human SOCS1 bands of approx. 30 kDa band and 25 kDa band are observed. These bands are not observed in the non-transfected HEK293. A similar pattern is observed in mouse spleen lysates. The calculated molecular size is 23.6 kDa band according to human NP_003736.1 and 23.7 kDa band according to mouse NP_034026.1.
IHC-P: Human kidney shows strong staining of the Brush Border in PCT.
Positive Control
Spleen Lysate (NB820-59670)
SOCS-1 Lysate (NBL1-16325)
Read Publication using NB100-781.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Rat, Canine, Bovine.

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
0.02% Sodium Azide
0.5 mg/ml
Immunogen affinity purified

Alternate Names for SOCS-1 Antibody

  • CIS1
  • Cish1
  • JAB
  • JABTec-interacting protein 3
  • JAK binding protein
  • JAK-binding protein
  • SOCS1
  • SOCS-1
  • SOCS-1CIS1
  • SSI-1
  • SSI-1CISH1
  • SSI1cytokine-inducible SH2 protein 1
  • STAT induced SH3 protein 1
  • STAT-induced STAT inhibitor 1
  • suppressor of cytokine signaling 1
  • TIP3
  • TIP-3
  • TIP3Cish1


Cytokines induce a variety of biologic responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways. Proteins that mediate these signals from the cell surface to the nucleus include Janus kinases, e.g., Janus kinase-1, and the signal transducers and activators of transcription (STATs), such as STAT1. To maintain tight control of these signal transduction pathways, mechanisms for turning off the signals are necessary. The adverse consequences of an imbalance between positive and negative signals is evident in the 'motheaten' mouse, which lacks the phosphatase SHP1. These mice fail to regulate cytokine responses appropriately, resulting in hyperproliferation and accumulation of cells in several hematopoietic lineages and the development of systemic autoimmune disease. SOCS1 represents a family of proteins that regulates responses to cytokines. SOCS1 (also known as Janus kinase-binding protein and STAT-induced STAT inhibitor-1) was isolated independently by its ability to interact with Janus kinase-2 in a 2-hybrid screen and on the basis of antigenic similarity with the SH2 domain of STAT3. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine-inducible SH2-containing protein).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SOCS-1 Antibody (NB100-781)(1)

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Gene Symbol SOCS1