Western Blot: NALP6 Antibody [NBP2-31372] - WB detection of NALP6 protein (NACHT, LRR and PYD domains-containing protein 6) in (A) Jurkat cells lysate and (B) partial recombinant protein using NALP6 antibody at a ...read more
Immunohistochemistry-Paraffin: NALP6 Antibody [NBP2-31372] - IHC-P analysis of NALP6 protein in a section of human breast normal tissue using NALP6 antibody at a concentration of 5 ug/ml. The breast ductal /acinar ...read more
NALP6 / NLRP6 (NACHT, LRR and PYD domains-containing protein 6) belongs to NLRP family of proteins - NLRP1, NLRP3, NLRC4 and NLRP6 - which functions as innate sensors of endogenous/exogenous stress or damage-associated molecular patterns (DAMPs). NLRPs are vital components of inflammasomes which are the cytoplasmic multi-protein complexes that coordinate several functions during inflammation and homeostasis in various type of cells/tissues. NLRP6 is a newly characterized NLR protein which is highly expressed in the intestinal epithelium as well as the granulocytes, and to a relatively lower levels on T-cells. NALP6 acts as an arginine-vasopressin V2 receptor and has been suggested to contribute to AVP-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. It implicates in the activation of CASP1 via ASC, promotion of NFkB activation and cAMP accumulation stimulation. NALP6 has been shown to actively participate in inflammasome signaling and to play critical roles in defense against infection, auto-inflammation and tumorigenesis.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.