NALP6 Antibody

Images

 
Western Blot: NALP6 Antibody [NBP2-31372] - WB detection of NALP6 protein (NACHT, LRR and PYD domains-containing protein 6) in (A) Jurkat cells lysate and (B) partial recombinant protein using NALP6 antibody at a ...read more
Immunohistochemistry-Paraffin: NALP6 Antibody [NBP2-31372] - IHC-P analysis of NALP6 protein in a section of human breast normal tissue using NALP6 antibody at a concentration of 5 ug/ml. The breast ductal /acinar ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

NALP6 Antibody Summary

Immunogen
Partial recombinant protein made to an N-terminal portion of human NALP6 (between amino acids 10-200) [UniProt P59044].
Localization
Cytoplasm, Nucleus and Cell membrane
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NLRP6
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

Human. Immunogen sequence similarity with other species: Rat (72%), Mouse (70%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for NALP6 Antibody

  • Angiotensin II/Vasopressin Receptor
  • AVR
  • CLR11.4
  • NACHT, Leucine Rich Repeat And PYD Containing 6
  • NACHT, LRR And PYD Containing Protein 6
  • NACHT, LRR And PYD Domains-Containing Protein 6
  • NALP6
  • NAVR
  • NAVR/AVR
  • NLR Family, Pyrin Domain Containing 6
  • NLRP6
  • NLRP6
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 6
  • PAN3
  • PYPAF5
  • PYRIN-Containing APAF1-Like Protein 5

Background

NALP6 / NLRP6 (NACHT, LRR and PYD domains-containing protein 6) belongs to NLRP family of proteins - NLRP1, NLRP3, NLRC4 and NLRP6 - which functions as innate sensors of endogenous/exogenous stress or damage-associated molecular patterns (DAMPs). NLRPs are vital components of inflammasomes which are the cytoplasmic multi-protein complexes that coordinate several functions during inflammation and homeostasis in various type of cells/tissues. NLRP6 is a newly characterized NLR protein which is highly expressed in the intestinal epithelium as well as the granulocytes, and to a relatively lower levels on T-cells. NALP6 acts as an arginine-vasopressin V2 receptor and has been suggested to contribute to AVP-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. It implicates in the activation of CASP1 via ASC, promotion of NFkB activation and cAMP accumulation stimulation. NALP6 has been shown to actively participate in inflammasome signaling and to play critical roles in defense against infection, auto-inflammation and tumorigenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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NALP6 NBP2-31372

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Diseases for NALP6 Antibody (NBP2-31372)

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Blogs on NALP6.

NALP6 - plays a critical role in suppressing inflammation and tumorigenesis
NALP6 belongs to the NLRP family of which function as innate sensors of endogenous and exogenous stress and damage-associated molecular patterns (DAMPs). NLRPs are vital components of the inflammasome which is the cytoplasmic multiprotein complex that...  Read full blog post.

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Bioinformatics

Gene Symbol NLRP6
Entrez
Uniprot