Immunohistochemistry: NALP4 Antibody [NB100-56156] - Formalin-fixed, paraffin-embedded tissue cores from a human breast cancer microarray stained for Smac/Diablo using NB100-56156 at 1:2000. Hematoxylin-eosin ...read more
Hu, MuSpecies Glossary
WB, IHC, IHC-P, IP
This product is unpurified. The exact concentration of antibody is not quantifiable.
nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 4
PAN2Ribonuclease inhibitor 2
PYPAF4PAAD and NACHT-containing protein 2
RNH2PYRIN-containing APAF1-like protein 4
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
NALP4 - Mediator of Programmed Cell Death The NALP family consists of cytoplasmic proteins within the larger CATERPILLER protein family. There exist in short forms (such as NALP4) and long forms (NALP1). NALP proteins include the apoptosis regulator apoptotic protease activating factor 1 (APA... Read full blog post.