NALP4 Antibody

Images

 
Immunohistochemistry: NALP4 Antibody [NB100-56156] - Formalin-fixed, paraffin-embedded tissue cores from a human breast cancer microarray stained for Smac/Diablo using NB100-56156 at 1:2000. Hematoxylin-eosin ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

NALP4 Antibody Summary

Immunogen
A synthetic peptide corresponding to amino acids 139-157 (FAPKETGKQPRTVIIQGPQ) of human NALP4/PAN2/PYPAF4 was used as immunogen; GenBank no. gi|17064172|gb|AAL35293.1|AF442488_1
Specificity
NALP4
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NLRP4
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000-1:2000
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:1000-1:5000
  • Immunoprecipitation 1:50-1:200
Publications
Read Publications using
NB100-56156 in the following applications:

  • WB
    3 publications

Reactivity Notes

Cross reacts with Human and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.02% Sodium Azide
Purity
Unpurified

Alternate Names for NALP4 Antibody

  • Cancer/testis antigen 58
  • CLR19.5
  • CT58PYRIN and NACHT-containing protein 2
  • FLJ32126
  • NACHT, leucine rich repeat and PYD containing 4
  • NACHT, LRR and PYD domains-containing protein 4
  • NALP4NACHT, LRR and PYD containing protein 4
  • NLR family, pyrin domain containing 4
  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 4
  • PAN2Ribonuclease inhibitor 2
  • PYPAF4PAAD and NACHT-containing protein 2
  • RNH2PYRIN-containing APAF1-like protein 4

Background

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for NALP4 Antibody (NB100-56156)(3)

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Blogs on NALP4.

NALP4 - Mediator of Programmed Cell Death
The NALP family consists of cytoplasmic proteins within the larger CATERPILLER protein family. There exist in short forms (such as NALP4) and long forms (NALP1). NALP proteins include the apoptosis regulator apoptotic protease activating factor 1 (APA...  Read full blog post.

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Bioinformatics

Gene Symbol NLRP4
Entrez
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