MYBPC1 Antibody - BSA Free

Western Blot: MYBPC1 Antibody [NBP2-41157] - Western blot analysis of MYBPC1 in rat skeletal muscle tissue lysate with MYBPC1 antibody at 1 ug/mL.

Immunocytochemistry/ Immunofluorescence: MYBPC1 Antibody - BSA Free [NBP2-41157] - Immunofluorescence of MYBPC1 in mouse skeletal muscle cells with MYBPC1 antibody at 20 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

MYBPC1 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit MYBPC1 Antibody - BSA Free (NBP2-41157) is a polyclonal antibody validated for use in WB, ELISA and ICC/IF. Anti-MYBPC1 Antibody: Cited in 2 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human MYBPC1. The immunogen is located within amino acids 160 - 210 of MYBPC1. Amino Acid Squence: DIRSAFKRSGEGQEDAGE
• Specificity: At least five isoforms of MYBPC1 are known to exist. MYBPC1 antibody is predicted not to cross-react with other MYBPC family members
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MYBPC1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence 20 ug/mL
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for MYBPC1 Antibody - BSA Free

• C-protein, skeletal muscle slow isoform
• MYBPCC
• MYBPCS
• myosin binding protein C, slow type
• myosin-binding protein C, slow-type
• skeletal muscle C-protein
• Slow MyBP-C
• slow-type

Background

MYBPC1, also known as Myosin-binding protein C, slow-type, is a protein with 10 isoforms ranging from a 1,120 amino acid isoform that is 126 kDa to a 1,173 amino acid isoform that is 131 kDa, located in the crossbridge region of vertebrate striated muscle a bands, plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments and modifies the activity of actin-activated myosin ATPase. Studies are being performed on the relationship of this protein to distal arthrogryposis, urethral intrinsic sphincter deficiency, akinetic mutism, hypertrophic cardiomyopathy, familial hypertrophic cardiomyopathy, dilated cardiomyopathy, dysgraphia, laryngeal squamous cell carcinoma, fg syndrome, atrial fibrillation, squamous cell carcinoma, mutism, muscular dystrophy, urethritis, polymyositis, laryngitis, dermatomyositis, myositis, distal arthrogryposis, and urethral intrinsic sphincter deficiency. MYBPC1 protein involvement has been observed with relation to CALM1, CALM2, CALM3, FHL1, MYBPC2, USP25, TTN, DYSF, ACTN2, and more than 30 other proteins in the muscle contraction and striated muscle contraction pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MYBPC1 Antibody (NBP2-41157)(2)

Publications using NBP2-41157

• Hessel AL, Engels NM, Kuehn M et al. Myosin-binding protein C forms C-links and stabilizes OFF states of myosin bioRxiv : the preprint server for biology 2023-09-12 [PMID: 37745361] (WB, Mouse)
• Teigen LE, Sundberg CW, Kelly LJ et al. Ca2+ dependency of limb muscle fiber contractile mechanics in young and older adults Am. J. Physiol., Cell Physiol. 2020-06-01 [PMID: 32348175]

Bioinformatics

• Gene Symbol: MYBPC1