Mouse VEGF Quantikine ELISA Kit, 2 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse VEGF Quantikine ELISA Kit, 2 Plate Summary

• Background: The Quantikine Mouse VEGF Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse VEGF in cell culture supernates, tissue homogenates, mouse serum, and plasma. It contains Sf 21-expressed mouse VEGF and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse VEGF accurately. Results obtained using natural mo...use VEGF showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse VEGF.
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• Specificity: This kit recognizes both the 164 and 120 amino acid residue forms of mouse VEGF
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Vegfa

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse VEGF Quantikine ELISA Kit, 2 Plate

• MVCD1
• VAS
• vascular endothelial growth factor A
• Vascular permeability factor
• Vasculotropin
• VEGF
• VEGFA
• VEGF-A
• VEGFMGC70609
• VPF
• VPFvascular endothelial growth factor

Background

Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and in adults (1-3). It is a member of the PDGF family that is characterized by the presence of eight conserved cysteine residues in a cystine knot structure and the formation of anti-parallel disulfide-linked dimers (4). Alternately spliced isoforms of 120, 164 and 188 amino acids (aa) have been found in mice, while 121, 145, 165, 183, 189, and 206 aa isoforms have been identified in humans (2, 4). In humans, VEGF₁₆₅ appears to be the most abundant and potent isoform, followed by VEGF₁₂₁ and VEGF₁₈₉ (3, 4). The same pattern may exist in mice. Isoforms other than VEGF₁₂₀ and VEGF₁₂₁ contain basic heparin-binding regions and are not freely diffusible (4). Mouse VEGF₁₆₄ shares 97% aa sequence identity with corresponding regions of rat VEGF. It also shares 89% aa sequence identity with human and porcine VEGF, 88% with bovine VEGF, and 90% with feline, equine, and canine VEGF. VEGF is expressed in multiple cells and tissues including skeletal and cardiac muscle (5, 6), hepatocytes (7), osteoblasts (8), neutrophils (9), macrophages (10), keratinocytes (11), brown adipose tissue (12), CD34⁺ stem cells (13), endothelial cells (14), fibroblasts, and vascular smooth muscle cells (15). VEGF expression is induced by hypoxia and cytokines such as IL-1, IL-6, IL-8, Oncostatin M, and TNF-alpha (3, 4, 9, 16). The isoforms are differentially expressed during development and in the adult (3). 

VEGF dimers bind to two related receptor tyrosine kinases, VEGF R1 (also called Flt-1) and VEGF R2 (Flk-1/KDR), and induce their homodimerization and autophosphorylation (3, 4, 7, 17, 18). These receptors have seven extracellular immunoglobulin-like domains and an intracellular split tyrosine kinase domain. They are expressed on vascular endothelial cells and a range of non-endothelial cells. Although VEGF affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity (3, 4). VEGF₁₆₅ also binds the semaphorin receptor, neuropilin-1, which promotes complex formation with VEGF R2 (19). 

VEGF is best known for its role in vasculogenesis. During embryogenesis, VEGF regulates the proliferation, migration, and survival of endothelial cells (3, 4), thus regulating blood vessel density and size but playing no role in determining vascular patterns. VEGF promotes bone formation through osteoblast and chondroblast recruitment and is also a monocyte chemoattractant (20-22). In postnatal life, VEGF maintains endothelial cell integrity and is a potent mitogen for micro- and macro-vascular endothelial cells. In adults, VEGF functions mainly in wound healing and the female reproductive cycle (3). In diseased tissues, VEGF promotes vascular permeability. It is thus thought to contribute to tumor metastasis by promoting both extravasation and tumor angiogenesis (23, 24). Various strategies have been employed therapeutically to antagonize VEGF-mediated tumor angiogenesis (25). Circulating VEGF levels correlate with disease activity in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus (26).

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for VEGF (MMV00)(205)

Publications using MMV00

• F Kasuga-Yam, T Baba, S Nagao, Y Fujibe, M Morishita, Y Kuno, T Mariya, H Honnma, T Endo, T Kiya, T Saito Letrozole increases preantral follicle growth and decreases estradiol production without impairing follicle survival Journal of ovarian research, 2022;15(1):136. 2022 [PMID: 36564850] (Mouse)
• J Yin, K Fang, Y Gao, L Ou, S Yuan, C Xin, W Wu, WW Wu, J Hong, H Yang, J Hu Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration Nature Communications, 2022;13(1):7867. 2022 [PMID: 36550137] (Mouse)
• J Yang, Y Ruan, D Wang, J Fan, N Luo, H Chen, X Li, W Chen, X Wang VHL-recruiting PROTAC attenuates renal fibrosis and preserves renal function via simultaneous degradation of Smad3 and stabilization of HIF-2alpha Cell & bioscience, 2022;12(1):203. 2022 [PMID: 36536448] (Mouse)
• J Liu, L Pan, W Hong, S Chen, P Bai, W Luo, X Sun, F He, X Jia, J Cai, Y Chen, K Hu, Z Song, J Ge, A Sun GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression Nature Communications, 2022;13(1):7519. 2022 [PMID: 36473866] (Transgenic Mouse)
• M Bohley, AE Dillinger, F Schweda, A Ohlmann, BM Braunger, ER Tamm, A Goepferich A single intravenous injection of cyclosporin A-loaded lipid nanocapsules prevents retinopathy of prematurity Science Advances, 2022;8(38):eabo6638. 2022 [PMID: 36149956] (Mouse)
• Y Matsuno, M Yanagihara, K Ueno, T Saito, H Kurazumi, R Suzuki, S Katsura, A Oga, K Hamano Dry preserved multilayered fibroblast cell sheets are a new manageable tool for regenerative medicine to promote wound healing Scientific Reports, 2022;12(1):12519. 2022 [PMID: 35869108] (Mouse)
• H Matsuno, S Tsuchimine, K O'Hashi, K Sakai, K Hattori, S Hidese, S Nakajima, S Chiba, A Yoshimura, N Fukuzato, M Kando, M Tatsumi, S Ogawa, N Ichinohe, H Kunugi, K Sohya Association between vascular endothelial growth factor-mediated blood-brain barrier dysfunction and stress-induced depression Molecular Psychiatry, 2022;0(0):. 2022 [PMID: 35618888] (Mouse)
• T Bork, W Liang, O Kretz, S Lagies, K Yamahara, C Hernando-E, M Helmstädte, C Schell, B Kammerer, TB Huber BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk International Journal of Molecular Sciences, 2022;23(7):. 2022 [PMID: 35409185] (Mouse)
• Y Feng, X Yang, J Huang, M Shen, L Wang, X Chen, Y Yuan, C Dong, X Ma, F Yuan Pharmacological Inhibition of Glutaminase 1 Attenuates Alkali-Induced Corneal Neovascularization by Modulating Macrophages Oxidative Medicine and Cellular Longevity, 2022;2022(0):1106313. 2022 [PMID: 35345831] (Mouse)
• J Fu, T Shinjo, Q Li, R St-Louis, K Park, MG Yu, H Yokomizo, F Simao, Q Huang, IH Wu, GL King Regenerating glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy JCI Insight, 2022;0(0):. 2022 [PMID: 35133981] (Mouse)
• EE Abd El-Fat, S Saber, ME Youssef, H Eissa, E El-Ahwany, NA Amin, M Alqarni, GE Batiha, AJ Obaidullah, MMY Kaddah, AG Ahmed Gaaf, AAE Mourad, G Mostafa-He, AM Abdelhamid AKT-AMPKalpha-mTOR-dependent HIF-1alpha Activation is a New Therapeutic Target for Cancer Treatment: A Novel Approach to Repositioning the Antidiabetic Drug Sitagliptin for the Management of Hepatocellular Carcinoma Frontiers in Pharmacology, 2021;12(0):720173. 2021 [PMID: 35095479] (Mouse)
• D An?i?, N Oršoli?, D Odeh, M Tomaševi?, I Pepi?, S Rami? Resveratrol and its nanocrystals: A promising approach for cancer therapy? Toxicology and Applied Pharmacology, 2021;435(0):115851. 2021 [PMID: 34971666] (Mouse)
• D Choe, ES Lee, A Beeghly-Fa, AJ Wilson, MM Whalen, SE Adunyah, DS Son High-Fat Diet-Induced Obese Effects of Adipocyte-Specific CXCR2 Conditional Knockout in the Peritoneal Tumor Microenvironment of Ovarian Cancer Cancers, 2021;13(19):. 2021 [PMID: 34638514] (Mouse)
• M Mesnieres, AM Böhm, N Peredo, D Trompet, R Valle-Tenn, M Bajaj, N Corthout, E Nefyodova, R Cardoen, P Baatsen, S Munck, A Nagy, JJ Haigh, S Khurana, CM Verfaillie, C Maes Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches Cell Reports, 2021;36(8):109618. 2021 [PMID: 34433017] (Mouse)
• T Mashima, T Wakatsuki, N Kawata, MK Jang, A Nagamori, H Yoshida, K Nakamura, T Migita, H Seimiya, K Yamaguchi Neutralization of the induced VEGF-A potentiates the therapeutic effect of an anti-VEGFR2 antibody on gastric cancer in vivo Scientific Reports, 2021;11(1):15125. 2021 [PMID: 34302038] (Mouse)
• H Nagano, Y Suematsu, M Takuma, S Aoki, A Satoh, E Takayama, M Kinoshita, Y Morimoto, S Takeoka, T Fujie, T Kiyosawa Enhanced cellular engraftment of adipose-derived mesenchymal stem cell spheroids by using nanosheets as scaffolds Scientific Reports, 2021;11(1):14500. 2021 [PMID: 34262089] (Mouse)
• M Jones-Muha, Q Shao, L Cain-Shiel, JP Shaffery, JP Warrington Acid Sensing Ion Channel 2a Is Reduced in the Reduced Uterine Perfusion Pressure Mouse Model and Increases Seizure Susceptibility in Pregnant Mice Cells, 2021;10(5):. 2021 [PMID: 34066660] (Mouse)
• CK Lin, TH Huang, CT Yang, CS Shi Roles of lung-recruited monocytes and pulmonary Vascular Endothelial Growth Factor (VEGF) in resolving Ventilator-Induced Lung Injury (VILI) PLoS ONE, 2021;16(3):e0248959. 2021 [PMID: 33740009] (Mouse)
• F Cheng, H Chang, F Yan, A Yang, J Liu, Y Liu Agomelatine Attenuates Isoflurane-Induced Inflammation and Damage in Brain Endothelial Cells Drug Design, Development and Therapy, 2020;14(0):5589-5598. 2020 [PMID: 33376303] (Mouse)
• Y Xiong, MJ Scerbo, A Seelig, F Volta, N O'Brien, A Dicker, D Padula, H Lickert, JM Gerdes, PO Berggren Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling Elife, 2020;9(0):. 2020 [PMID: 33200981] (Human)
• A Usui-Ouchi, E Aguilar, S Murinello, M Prins, ML Gantner, PE Wright, RB Berlow, M Friedlande An allosteric peptide inhibitor of HIF-1&alpha regulates hypoxia-induced retinal neovascularization Proc Natl Acad Sci U S A, 2020;0(0):. 2020 [PMID: 33106407] (Mouse)
• PL Mulcrone, SKE Edwards, DN Petrusca, LS Haneline, J Delgado-Ca, GD Roodman Osteocyte Vegf-a contributes to myeloma-associated angiogenesis and is regulated by Fgf23 Sci Rep, 2020;10(1):17319. 2020 [PMID: 33057033] (Mouse)
• K Hosaka, Y Yang, T Seki, Q Du, X Jing, X He, J Wu, Y Zhang, H Morikawa, M Nakamura, M Scherzer, X Sun, Y Xu, T Cheng, X Li, X Liu, Q Li, Y Liu, A Hong, Y Chen, Y Cao Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors Nat Commun, 2020;11(1):3704. 2020 [PMID: 32709869] (Mouse)
• MY Ahn, BJ Kim, HJ Kim, JM Jin, HJ Yoon, JS Hwang, BM Lee Anti-diabetic activity of field cricket glycosaminoglycan by ameliorating oxidative stress BMC Complement Med Ther, 2020;20(1):232. 2020 [PMID: 32698784] (Mouse)
• K Maruyama, H Kidoya, N Takemura, E Sugisawa, O Takeuchi, T Kondo, MMA Eid, H Tanaka, MM Martino, N Takakura, Y Takayama, S Akira, A Vandenbon, Y Kumagai Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages Cell Rep, 2020;32(2):107906. 2020 [PMID: 32668247] (Mouse)
• H Quan, Y Kim, L Wu, HC Park, HC Yang Modulation of Macrophage Polarization by Phospholipids on the Surface of Titanium Molecules, 2020;25(11):. 2020 [PMID: 32532146] (Mouse)
• H Watanabe, S Goto, R Kato, S Komiyama, Y Nagaoka, T Kazama, C Yamamoto, Y Li, N Konuma, K Hagikura, T Matsumoto The neovascularization effect of dedifferentiated fat cells Sci Rep, 2020;10(1):9211. 2020 [PMID: 32514018] (Mouse)
• S Huerta-Yep, A Tirado-Rod, MR Montecillo, J Yang, BD Hammock, O Hankinson Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression Sci Rep, 2020;10(1):7843. 2020 [PMID: 32398692] (Mouse)
• T Miyagawa, ZY Chen, CY Chang, KH Chen, YK Wang, GS Liu, CL Tseng Topical Application of Hyaluronic Acid-RGD Peptide-Coated Gelatin/Epigallocatechin-3 Gallate (EGCG) Nanoparticles Inhibits Corneal Neovascularization Via Inhibition of VEGF Production Pharmaceutics, 2020;12(5):. 2020 [PMID: 32354067] (Mouse)
• S Lee, HS Roh, SS Song, J Shin, J Lee, DH Bhang, BG Kim, SH Um, HS Jeong, KH Baek Loss of S6K1 But Not S6K2 in the Tumor Microenvironment Suppresses Tumor Growth by Attenuating Tumor Angiogenesis Transl Oncol, 2020;13(4):100767. 2020 [PMID: 32251993] (Mouse)
• M Jerebtsova, A Ahmad, X Niu, O Rutagarama, S Nekhai HIV-1 Transcription Inhibitor 1E7-03 Restores LPS-Induced Alteration of Lung Leukocytes' Infiltration Dynamics and Resolves Inflammation in HIV Transgenic Mice Viruses, 2020;12(2):. 2020 [PMID: 32059509] (Mouse)
• M Kawaguchi, K Yamamoto, H Kataoka, A Izumi, F Yamashita, T Kiwaki, T Nishida, E Camerer, T Fukushima Protease-activated receptor-2 accelerates intestinal tumor formation through activation of nuclear factor-&kappaB signaling and tumor angiogenesis in ApcMin/+ mice Cancer Sci., 2020;111(4):1193-1202. 2020 [PMID: 31997435] (Human)
• F Njau, N Shushakova, H Schenk, VC Wulfmeyer, R Bollin, J Menne, H Haller Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice PLoS ONE, 2020;15(1):e0218494. 2020 [PMID: 31935212] (Mouse)
• YL Chuang, HW Fang, A Ajitsaria, KH Chen, CY Su, GS Liu, CL Tseng Development of Kaempferol-Loaded Gelatin Nanoparticles for the Treatment of Corneal Neovascularization in Mice Pharmaceutics, 2019;11(12):. 2019 [PMID: 31795237] (Mouse)
• C Li, J Pan, L Ye, H Xu, B Wang, H Xu, L Xu, T Hou, D Zhang Autophagy regulates the therapeutic potential of adipose-derived stem cells in LPS-induced pulmonary microvascular barrier damage Cell Death Dis, 2019;10(11):804. 2019 [PMID: 31645547] (Mouse)
• SV Jenkins, MS Robeson, RJ Griffin, CM Quick, ER Siegel, MJ Cannon, KB Vang, RPM Dings Gastrointestinal tract dysbiosis enhances distal tumor progression through suppression of leukocyte trafficking Cancer Res., 2019;0(0):. 2019 [PMID: 31591154] (Mouse)
• YZ Zhou, Z Cheng, Y Wu, QY Wu, XB Liao, Y Zhao, JM Li, XM Zhou, XM Fu Mesenchymal stem cell-derived conditioned medium attenuate angiotensin II-induced aortic aneurysm growth by modulating macrophage polarization J. Cell. Mol. Med., 2019;0(0):. 2019 [PMID: 31583844] (Mouse)
• AM Zaw, R Sekar, SOK Mak, HKW Law, BKC Chow Loss of secretin results in systemic and pulmonary hypertension with cardiopulmonary pathologies in mice Sci Rep, 2019;9(1):14211. 2019 [PMID: 31578376] (Mouse)
• M Karwicka, B Pucelik, M Gonet, M Elas, JM D?browski Effects of Photodynamic Therapy with Redaporfin on Tumor Oxygenation and Blood Flow in a Lung Cancer Mouse Model Sci Rep, 2019;9(1):12655. 2019 [PMID: 31477749] (Mouse)
• R Fu, CF Han, T Ni, L Di, LJ Liu, WC Lv, YR Bi, N Jiang, Y He, HM Li, S Wang, H Xie, BA Chen, XS Wang, SJ Weiss, T Lu, QL Guo, ZQ Wu A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours Nat Commun, 2019;10(1):3210. 2019 [PMID: 31324807] (Mouse)
• S Saraswati, SMW Marrow, LA Watch, PP Young Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing Nat Commun, 2019;10(1):3027. 2019 [PMID: 31289275] (Mouse)
• Y Martín-Mar, L Fernández-, MH Sanchez-Re, N Marí-Buyé, FJ Rojo, J Pérez-Rigu, M Ramos, GV Guinea, F Panetsos, D González-N Evaluation of Neurosecretome from Mesenchymal Stem Cells Encapsulated in Silk Fibroin Hydrogels Sci Rep, 2019;9(1):8801. 2019 [PMID: 31217546] (Mouse)
• M Liang, Q Ma, N Ding, F Luo, Y Bai, F Kang, X Gong, R Dong, J Dai, Q Dai, C Dou, S Dong IL-11 is essential in promoting osteolysis in breast cancer bone metastasis via RANKL-independent activation of osteoclastogenesis Cell Death Dis, 2019;10(5):353. 2019 [PMID: 31040267] (Mouse)
• H Shi, X Fan, A Horton, ST Haller, DJ Kennedy, IT Schiefer, L Dworkin, CJ Cooper, J Tian The Effect of Electronic-Cigarette Vaping on Cardiac Function and Angiogenesis in Mice Sci Rep, 2019;9(1):4085. 2019 [PMID: 30858470] (Mouse)
• BS Hong, HS Ryu, N Kim, J Kim, E Lee, H Moon, KH Kim, MS Jin, NH Kwon, S Kim, D Kim, DH Chung, K Jeong, K Kim, KY Kim, HB Lee, W Han, J Yun, JI Kim, DY Noh, HG Moon Tumor suppressor microRNA-204-5p regulates growth, metastasis, and immune microenvironment remodeling in breast cancer Cancer Res., 2019;0(0):. 2019 [PMID: 30737233] (Mouse)
• M Subileau, G Merdzhanov, D Ciais, V Collin-Fau, JJ Feige, S Bailly, D Vittet Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation Stem Cell Reports, 2018;0(0):. 2018 [PMID: 30595547] (Mouse)
• C Ozek, RC Krolewski, SM Buchanan, LL Rubin Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice Sci Rep, 2018;8(1):17293. 2018 [PMID: 30470794] (Mouse)
• Sandeep Kumar Vishwakarm, Avinash Bardia, Chandrakala Lakkiredd, Syed Ameer Basha Paspala, Aleem Ahmed Khan Bioengineering Human Neurological Constructs Using Decellularized Meningeal Scaffolds for Application in Spinal Cord Injury. Frontiers in Bioengineering and Biotechnology, 2018;0(0):2296-4185. 2018 [PMID: 30443545] (Xenograft)
• B Cakir, R Liegl, G Hellgren, P Lundgren, Y Sun, S Klevebro, C Löfqvist, C Mannheimer, S Cho, A Poblete, R Duran, B Hallberg, J Canas, V Lorenz, ZJ Liu, MC Sola-Visne, LE Smith, A Hellström Thrombocytopenia is associated with severe retinopathy of prematurity JCI Insight, 2018;3(19):. 2018 [PMID: 30282834] (Mouse)
• Z Jian, T Cheng, Z Zhang, S Raulefs, K Shi, K Steiger, N Maeritz, K Kleigrewe, T Hofmann, S Benitz, P Bruns, D Lamp, M Jastroch, J Akkan, C Jäger, P Huang, S Nie, S Shen, X Zou, GO Ceyhan, CW Michalski, H Friess, J Kleeff, B Kong Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma Cell Mol Gastroenterol Hepatol, 2018;6(4):429-449. 2018 [PMID: 30258965] (Mouse)
• F Sasaki, T Koga, M Ohba, K Saeki, T Okuno, K Ishikawa, T Nakama, S Nakao, S Yoshida, T Ishibashi, H Ahmadieh, MR Kanavi, A Hafezi-Mog, JM Penninger, KH Sonoda, T Yokomizo Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models JCI Insight, 2018;3(18):. 2018 [PMID: 30232269] (Mouse)
• M Ouarné, C Bouvard, G Boneva, C Mallet, J Ribeiro, A Desroches-, E Soleilhac, E Tillet, O Peyruchaud, S Bailly BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer J. Exp. Clin. Cancer Res., 2018;37(1):209. 2018 [PMID: 30165893] (Mouse)
• J Steenbrugg, K Breyne, K Demeyere, O De Wever, NN Sanders, W Van Den Br, C Colpaert, P Vermeulen, S Van Laere, E Meyer Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer J. Exp. Clin. Cancer Res., 2018;37(1):191. 2018 [PMID: 30111338] (Mouse)
• JK Christians, KI Lennie, MF Huicochea, N Binning PAPP-A2 deficiency does not exacerbate the phenotype of a mouse model of intrauterine growth restriction Reprod. Biol. Endocrinol., 2018;16(1):58. 2018 [PMID: 29895300] (Mouse)
• T Mizoguchi, K Ueno, Y Takeuchi, M Samura, R Suzuki, T Murata, T Hosoyama, N Morikage, K Hamano Treatment of Cutaneous Ulcers with Multilayered Mixed Sheets of Autologous Fibroblasts and Peripheral Blood Mononuclear Cells Cell. Physiol. Biochem., 2018;47(1):201-211. 2018 [PMID: 29763904] (Mouse)
• T Koo, SW Park, DH Jo, D Kim, JH Kim, HY Cho, J Kim, JH Kim, JS Kim CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration Nat Commun, 2018;9(1):1855. 2018 [PMID: 29748595] (Mouse)
• M Mastri, CR Lee, A Tracz, RS Kerbel, M Dolan, Y Shi, JML Ebos Tumor-independent host secretomes induced by angiogenesis and immune-checkpoint inhibitors Mol. Cancer Ther., 2018;0(0):. 2018 [PMID: 29695634] (Mouse)
• E Groppa, S Brkic, A Uccelli, G Wirth, P Korpisalo-, M Filippova, B Dasen, V Sacchi, MG Muraro, M Trani, S Reginato, R Gianni-Bar, S Ylä-Herttu, A Banfi EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF EMBO Rep., 2018;0(0):. 2018 [PMID: 29643120] (Human)
• LK Ong, WZ Chow, C TeBay, M Kluge, G Pietrogran, K Zalewska, P Crock, ND Åberg, A Bivard, SJ Johnson, FR Walker, M Nilsson, J Isgaard Growth Hormone Improves Cognitive Function After Experimental Stroke Stroke, 2018;0(0):. 2018 [PMID: 29636425] (Mouse)
• LF Seet, LZ Toh, S Chu, SN Finger, F Ginhoux, W Hong, TT Wong Bevacizumab Promotes T-Cell-Mediated Collagen Deposition in the Mouse Model of Conjunctival Scarring Invest. Ophthalmol. Vis. Sci., 2018;59(3):1682-1692. 2018 [PMID: 29625495] (Mouse)
• A Longchamp, T Mirabella, A Arduini, MR MacArthur, A Das, JH Treviño-Vi, C Hine, I Ben-Sahra, NH Knudsen, LE Brace, J Reynolds, P Mejia, M Tao, G Sharma, R Wang, JM Corpataux, JA Haefliger, KH Ahn, CH Lee, BD Manning, DA Sinclair, CS Chen, CK Ozaki, JR Mitchell Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production Cell, 2018;173(1):117-129.e14. 2018 [PMID: 29570992] (Mouse)
• P Mésange, A Bouygues, N Ferrand, M Sabbah, AE Escargueil, A Savina, B Chibaudel, C Tournigand, T Andre, A de Gramont, AK Larsen Combinations of Bevacizumab and Erlotinib show activity in colorectal cancer independent of RAS status Clin. Cancer Res., 2018;0(0):. 2018 [PMID: 29490990] (Mouse)
• JY Chung, JH Ko, YJ Lee, HS Choi, YH Kim Surfactant-free solubilization and systemic delivery of anti-cancer drug using low molecular weight methylcellulose J Control Release, 2018;0(0):. 2018 [PMID: 29476882] (Mouse)
• B Dhole, S Gupta, SK Venugopal, A Kumar Triiodothyronine stimulates VEGF expression and secretion via steroids and HIF-1? in murine Leydig cells Syst Biol Reprod Med, 2018;0(0):1-11. 2018 [PMID: 29417848] (Human)
• YR Kim, SM Ahn, ME Pak, HJ Lee, DH Jung, YI Shin, HK Shin, BT Choi Potential benefits of mesenchymal stem cells and electroacupuncture on the trophic factors associated with neurogenesis in mice with ischemic stroke Sci Rep, 2018;8(1):2044. 2018 [PMID: 29391466] (Mouse)
• M Nagao, JL Hamilton, R Kc, AD Berendsen, X Duan, CW Cheong, X Li, HJ Im, BR Olsen Vascular Endothelial Growth Factor in Cartilage Development and Osteoarthritis Sci Rep, 2017;7(1):13027. 2017 [PMID: 29026147] (Mouse)
• L Kumar Dube, P Karempudi, SA Luther, B Ludewig, NL Harris Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis Nat Commun, 2017;8(1):367. 2017 [PMID: 28848229] (Mouse)
• A Vilaseca, N Campillo, M Torres, M Musquera, D Gozal, JM Montserrat, A Alcaraz, KA Touijer, R Farré, I Almendros Intermittent hypoxia increases kidney tumor vascularization in a murine model of sleep apnea PLoS ONE, 2017;12(6):e0179444. 2017 [PMID: 28594929] (Mouse)
• D Wang, H Sun, J Wei, B Cen, RN DuBois CXCL1 is critical for pre-metastatic niche formation and metastasis in colorectal cancer Cancer Res., 2017;0(0):. 2017 [PMID: 28455419] (Mouse)
• MH Sun, MA Shariati, YJ Liao Experimental Anterior Ischemic Optic Neuropathy in Diabetic Mice Exhibited Severe Retinal Swelling Associated With VEGF Elevation Invest. Ophthalmol. Vis. Sci., 2017;58(4):2296-2305. 2017 [PMID: 28431433] (Mouse)
• KM Gutpell, N Tasevski, B Wong, WT Hrinivich, F Su, J Hadway, L Desjardins, TY Lee, LM Hoffman ANG1 treatment reduces muscle pathology and prevents a decline in perfusion in DMD mice PLoS ONE, 2017;12(3):e0174315. 2017 [PMID: 28334037] (Mouse)
• TW Seeley, MD Sternlicht, SJ Klaus, TB Neff, DY Liu Induction of erythropoiesis by hypoxia-inducible factor prolyl hydroxylase inhibitors without promotion of tumor initiation, progression, or metastasis in a VEGF-sensitive model of spontaneous breast cancer Hypoxia (Auckl), 2017;5(0):1-9. 2017 [PMID: 28331872] (Mouse)
• P Himmels, I Paredes, H Adler, A Karakatsan, R Luck, HH Marti, O Ermakova, E Rempel, ET Stoeckli, C Ruiz de Al Motor neurons control blood vessel patterning in the developing spinal cord Nat Commun, 2017;8(0):14583. 2017 [PMID: 28262664] (Mouse)
• E Kim, T Koo, SW Park, D Kim, K Kim, HY Cho, DW Song, KJ Lee, MH Jung, S Kim, JH Kim, JH Kim, JS Kim In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni Nat Commun, 2017;8(0):14500. 2017 [PMID: 28220790] (Mouse)
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• Tsao PN, Chan FT, Wei SC, Hsieh WS, Chou HC, Su YN, Chen CY, Hsu WM, Hsieh FJ, Hsu SM Soluble vascular endothelial growth factor receptor-1 protects mice in sepsis. Crit. Care Med., 2007;35(8):1955-60. 2007 [PMID: 17568329] (Mouse)
• Dai Y, Xu M, Wang Y, Pasha Z, Li T, Ashraf M HIF-1alpha induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemia. J. Mol. Cell. Cardiol., 2007;42(6):1036-44. 2007 [PMID: 17498737] (Mouse)
• Cahill RA, Wang JH, Redmond HP Enteric bacteria and their antigens may stimulate postoperative peritoneal adhesion formation. Surgery, 2007;141(3):403-10. 2007 [PMID: 17349853] (Mouse)
• Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat. Med., 2006;12(11):1286-93. 2006 [PMID: 17086189] (Mouse)
• Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex. Blood, 2007;109(5):2234-42. 2007 [PMID: 17082320] (Mouse)
• Cianfarani F, Zambruno G, Brogelli L, Sera F, Lacal PM, Pesce M, Capogrossi MC, Failla CM, Napolitano M, Odorisio T Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential. Am. J. Pathol., 2006;169(4):1167-82. 2006 [PMID: 17003476] (Mouse)
• Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol. Cell. Biol., 2006;26(22):8336-46. 2006 [PMID: 16966370] (Mouse)
• Henke PK, Pearce CG, Moaveni DM, Moore AJ, Lynch EM, Longo C, Varma M, Dewyer NA, Deatrick KB, Upchurch GR, Wakefield TW, Hogaboam C, Kunkel SL Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model. J. Immunol., 2006;177(5):3388-97. 2006 [PMID: 16920980] (Mouse)
• Yamaji-Kegan K, Su Q, Angelini DJ, Champion HC, Johns RA Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2. Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(6):L1159-68. 2006 [PMID: 16891392] (Mouse)
• Stamatovic SM, Keep RF, Mostarica-Stojkovic M, Andjelkovic AV CCL2 regulates angiogenesis via activation of Ets-1 transcription factor. J. Immunol., 2006;177(4):2651-61. 2006 [PMID: 16888027] (Mouse)
• Cahill RA, Wang JH, Soohkai S, Redmond HP Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions. Surgery, 2006;140(1):108-12. 2006 [PMID: 16857448] (Mouse)
• Kornek M, Raskopf E, Guetgemann I, Ocker M, Gerceker S, Gonzalez-Carmona MA, Rabe C, Sauerbruch T, Schmitz V Combination of systemic thioacetamide (TAA) injections and ethanol feeding accelerates hepatic fibrosis in C3H/He mice and is associated with intrahepatic up regulation of MMP-2, VEGF and ICAM-1. J. Hepatol., 2006;45(3):370-6. 2006 [PMID: 16780996] (Mouse)
• Genovese T, Mazzon E, Di Paola R, Muia C, Crisafulli C, Malleo G, Esposito E, Cuzzocrea S Role of peroxisome proliferator-activated receptor-alpha in acute pancreatitis induced by cerulein. Immunology, 2006;118(4):559-70. 2006 [PMID: 16764691] (Mouse)
• Wang CH, Verma S, Hsieh IC, Chen YJ, Kuo LT, Yang NI, Wang SY, Wu MY, Hsu CM, Cheng CW, Cherng WJ Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system. J. Mol. Cell. Cardiol., 2006;41(1):34-43. 2006 [PMID: 16678199] (Mouse)
• Wislez M, Fujimoto N, Izzo JG, Hanna AE, Cody DD, Langley RR, Tang H, Burdick MD, Sato M, Minna JD, Mao L, Wistuba I, Strieter RM, Kurie JM High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res., 2006;66(8):4198-207. 2006 [PMID: 16618742] (Mouse)
• Schmitz V, Vilanueva H, Raskopf E, Hilbert T, Barajas M, Dzienisowicz C, Gorschluter M, Strehl J, Rabe C, Sauerbruch T, Prieto J, Caselmann WH, Qian C Increased VEGF levels induced by anti-VEGF treatment are independent of tumor burden in colorectal carcinomas in mice. Gene Ther., 2006;13(16):1198-205. 2006 [PMID: 16617302] (Mouse)
• Pourgholami MH, Yan Cai Z, Lu Y, Wang L, Morris DL Albendazole: a potent inhibitor of vascular endothelial growth factor and malignant ascites formation in OVCAR-3 tumor-bearing nude mice. Clin. Cancer Res., 2006;12(6):1928-35. 2006 [PMID: 16551879] (Mouse)
• Hahn T, Alvarez I, Kobie JJ, Ramanathapuram L, Dial S, Fulton A, Besselsen D, Walker E, Akporiaye ET Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer. Int. J. Cancer, 2006;118(9):2220-31. 2006 [PMID: 16331615] (Mouse)
• Stathopoulos GT, Zhu Z, Everhart MB, Kalomenidis I, Lawson WE, Bilaceroglu S, Peterson TE, Mitchell D, Yull FE, Light RW, Blackwell TS Nuclear factor-kappaB affects tumor progression in a mouse model of malignant pleural effusion. Am. J. Respir. Cell Mol. Biol., 2005;34(2):142-50. 2005 [PMID: 16210694] (Mouse)
• Streck CJ, Zhang Y, Zhou J, Ng C, Nathwani AC, Davidoff AM Adeno-associated virus vector-mediated delivery of pigment epithelium-derived factor restricts neuroblastoma angiogenesis and growth. J. Pediatr. Surg., 2005;40(1):236-43. 2005 [PMID: 15868591] (Mouse)
• Ito Y, Betsuyaku T, Nagai K, Nasuhara Y, Nishimura M Expression of pulmonary VEGF family declines with age and is further down-regulated in lipopolysaccharide (LPS)-induced lung injury. Exp. Gerontol., 2005;40(4):315-23. 2005 [PMID: 15820612] (Mouse)
• Duman S, Sen S, Duman C, Oreopoulos DG Effect of valsartan versus lisinopril on peritoneal sclerosis in rats. Int J Artif Organs, 2005;28(2):156-63. 2005 [PMID: 15770604] (Rat)
• Jensen KK, Manfra DJ, Grisotto MG, Martin AP, Vassileva G, Kelley K, Schwartz TW, Lira SA The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma. J. Immunol., 2005;174(6):3686-94. 2005 [PMID: 15749907] (Mouse)
• Isayeva T, Ren C, Ponnazhagan S Recombinant adeno-associated virus 2-mediated antiangiogenic prevention in a mouse model of intraperitoneal ovarian cancer. Clin. Cancer Res., 2005;11(3):1342-7. 2005 [PMID: 15709207] (Mouse)
• Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation. J. Immunol., 2005;174(1):215-22. 2005 [PMID: 15611243] (Mouse)
• Rota R, Riccioni T, Zaccarini M, Lamartina S, Gallo AD, Fusco A, Kovesdi I, Balestrazzi E, Abeni DC, Ali RR, Capogrossi MC Marked inhibition of retinal neovascularization in rats following soluble-flt-1 gene transfer. J Gene Med, 2004;6(9):992-1002. 2004 [PMID: 15352072] (Rat)
• Dong G, Lee TL, Yeh NT, Geoghegan J, Van Waes C Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering and metastasis in response to hepatocyte growth factor. Oncogene, 2004;23(37):6199-208. 2004 [PMID: 15221009] (Mouse)
• Kodama I, Sanada M, Yoshiko Y, Tsuda M, Ohama K Estrogen regulates the production of VEGF for osteoclast formation and activity in op/op mice. J. Bone Miner. Res., 2004;19(2):200-6. 2004 [PMID: 14969389] (Mouse)
• Usui T, Ishida S, Yamashiro K, Kaji Y, Poulaki V, Moore J, Moore T, Amano S, Horikawa Y, Dartt D, Golding M, Shima DT, Adamis AP VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2. Invest. Ophthalmol. Vis. Sci., 2004;45(2):368-74. 2004 [PMID: 14744874] (Mouse)
• Easwaran V, Lee SH, Inge L, Guo L, Goldbeck C, Garrett E, Wiesmann M, Garcia PD, Fuller JH, Chan V, Randazzo F, Gundel R, Warren RS, Escobedo J, Aukerman SL, Taylor RN, Fantl WJ beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res., 2003;63(12):3145-53. 2003 [PMID: 12810642] (Mouse)
• Oura H, Bertoncini J, Velasco P, Brown LF, Carmeliet P, Detmar M A critical role of placental growth factor in the induction of inflammation and edema formation. Blood, 2002;101(2):560-7. 2002 [PMID: 12393422] (Mouse)
• Kozawa O, Yoshimi N, Akamatsu S, Hara A, Mori H, Uematsu T Lack of alpha2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction. Blood, 2002;100(7):2487-93. 2002 [PMID: 12239160] (Mouse)
• Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MA, Werb Z, Rafii S Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell, 2002;109(5):625-37. 2002 [PMID: 12062105] (Mouse)
• Margetts PJ, Kolb M, Galt T, Hoff CM, Shockley TR, Gauldie J Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function. J. Am. Soc. Nephrol., 2001;12(10):2029-39. 2001 [PMID: 11562401] (Rat)
• Gabrilovich DI, 2018, Ishida T, Nadaf S, Ohm JE, Carbone DP Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. 1537, 1999;5(10):2963-70. 1999 [PMID: 10537366] (Mouse)

FAQs for VEGF (MMV00). (Showing 1 - 1 of 1 FAQs).

1. Why is the molecular weight of VEGF different from the similar antibody, for some companies the the molecular weight is 40KD)?
   • I can't comment on another company's antibody because I don't have any information about their products. I can tell you that VEGF is expressed in a variety of isoforms and is subject to various post-translational modifications that influence its apparent molecular weight in an SDS-PAGE gel compared to the theoretical molecular weight.

Bioinformatics

• Gene Symbol: Vegfa