MAVS Products

Antibodies
MAVS Antibody
MAVS Antibody
NB100-80859
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
MAVS Antibody
MAVS Antibody
NBP1-77275
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IHC-P, IF
Host: Rabbit Polyclonal
Lysates
MAVS Overexpression Lysate (D ...
MAVS Overexpression Lysate (Denatu...
H00057506-T01
Species: Hu
Applications: WB
MAVS Overexpression Lysate (N ...
MAVS Overexpression Lysate (Native)
NBP2-06621
Applications: WB
Proteins
Recombinant Human MAVS Protei ...
Recombinant Human MAVS Protein
NBP2-23238
Species: Hu
Applications: PAGE
MAVS Recombinant Protein Anti ...
MAVS Recombinant Protein Antigen
NBP2-38613PEP
Species: Hu
Applications: AC
MAVS Recombinant Protein Anti ...
MAVS Recombinant Protein Antigen
NBP2-38704PEP
Species: Hu
Applications: AC

Description

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005).[supplied by OMIM]

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 57506
Alternate Names
  • virus-induced signaling adaptor variant 1a
  • DKFZp666M015
  • virus-induced signaling adapter variant 1b
  • DKFZp547C224
  • mitochondrial antiviral-signaling protein
  • CARDIF
  • mitochondrial viral signaling protein
  • CARD adapter inducing interferon beta
  • interferon-beta promoter stimulator protein 1
  • Virus-induced-signaling adapter
  • IFN-B promoter stimulator 1
  • Putative NF-kappa-B-activating protein 031N
  • CARD adaptor inducing IFN-beta
  • Interferon beta promoter stimulator protein 1
  • CARD adapter inducing interferon-beta
  • Cardif
  • IPS1MGC3260
  • IPS-1FLJ41962
  • VISAFLJ38051
  • KIAA1271FLJ35386
  • FLJ27482
  • mitochondrial antiviral signaling protein

Research Areas for MAVS

Find related products by research area and learn more about each of the different research areas below.

Immune System Diseases
Immunology
Protein Kinase

PTMs for MAVS

Learn more about PTMs related to MAVS.

Cleavage
Phosphorylation
Ubiquitination
Reduction

Bioinformatics Tool for MAVS

Discover related pathways, diseases and genes to MAVS. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related MAVS Blog Posts

Check out the latest blog posts on MAVS.
STING in Innate Immunity and Cancer: What’s the Buzz About?
STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also...    Read more.
Read more MAVS related blogs.