Kininogen/Kininostatin/Bradykinin Antibody

Images

 
There are currently no images for Kininogen/Kininostatin/Bradykinin Antibody (AF1396).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
View Available Formulations
Catalog# & Formulation Size Price

Kininogen/Kininostatin/Bradykinin Antibody Summary

Immunogen
E. coli-derived recombinant human Kininostatin
Lys438-Ser531
Accession # P01042
Specificity
Detects human Kininogen/Kininostatin in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
KNG1
Purity
Immunogen affinity purified
Endotoxin Note
<0.20 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF1396 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Kininogen/Kininostatin/Bradykinin Antibody

  • Alpha-2-thiol proteinase inhibitor
  • BDK
  • bradykinin
  • Fitzgerald factor
  • High molecular weight kininogen
  • kininogen 1
  • kininogen
  • Kininogen/Kininostatin
  • kininogen-1
  • KNGHMWK
  • Williams-Fitzgerald-Flaujeac factor

Background

High molecular weight kininogen (HK) is a secreted plasma glycoprotein consisting of six domains (D1 through D6). It binds specifically to endothelial cells and serves as a substrate of plasma kallikrein which releases bradykinin from within D4 of HK. Bradykinin is an active peptide that regulates multiple vascular processes. The resulting cleaved HK, called HKa, is a disulfide-linked dimer containing a heavy chain (D1 to D3) and a light chain (D5 and D6). HKa differs from HK in conformation and possesses new functional properties. It is a potent angiogenesis inhibitor that strongly inhibits endothelial cell proliferation and migration. HKa also induces apoptosis of endothelial cells. D5 of HKa has been shown to be the active region primarily responsible for the HKa anti-angiogenic activity and has been named kininostatin. While both HK and HKa are plasma proteins that are present in circulation, it is not known if kininostatin (D5) can be released from HKa and exist in plasma (1-4).

  1. Guo, Y. et al. (2002) International Immunopharmacology 2:1931.
  2. Zhang, J. et al. (2000) FASEB 14:2589.
  3. Colman, R.W. et al. (2000) Blood 95(2): 543.
  4. Guo, Y. et al. (2001) Arterioscler. Thromb. Vasc. Biol. 21:1427.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NBP1-30027
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
AF1513
Species: Mu
Applications: WB, Simple Western, Flow, IHC, IP, CyTOF-ready
NBP2-38449
Species: Hu
Applications: ICC/IF, IHC, IHC-P
NB300-187
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC
MAB35661
Species: Hu
Applications: WB, IHC, IP, Neut
NBP1-89522
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NBP1-88927
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
AF2498
Species: Mu
Applications: WB, IP
NBP1-43435
Species: Hu, Mu
Applications: WB, Flow
H00728695-B01P
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
MAB1569
Species: Hu
Applications: WB, IHC, IP
NBP1-94203
Species: Hu, Mu, Rt, Pm
Applications: WB, ICC/IF, IHC, IHC-P
NLS3580
Species: Hu, Mk, Pm
Applications: IHC, IHC-P
NBP2-67717
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P
NBP1-31559
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NB300-500
Species: Hu, Mu, Rt, Po, Am, Bv, Ca, Dr
Applications: WB, IHC, IHC-Fr, IHC-P
NB600-41532
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
NBP2-24916
Species: Hu, Mu, Rt, Bv
Applications: WB, IHC, IHC-P
AF1396
Species: Hu
Applications: WB

Publications for Kininogen/Kininostatin/Bradykinin Antibody (AF1396)(3)

Reviews for Kininogen/Kininostatin/Bradykinin Antibody (AF1396) (0)

There are no reviews for Kininogen/Kininostatin/Bradykinin Antibody (AF1396). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Kininogen/Kininostatin/Bradykinin Antibody (AF1396) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin BAF1396

Additional Kininogen/Kininostatin/Bradykinin Products

Bioinformatics Tool for Kininogen/Kininostatin/Bradykinin Antibody (AF1396)

Discover related pathways, diseases and genes to Kininogen/Kininostatin/Bradykinin Antibody (AF1396). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Kininogen/Kininostatin/Bradykinin Antibody (AF1396)

Discover more about diseases related to Kininogen/Kininostatin/Bradykinin Antibody (AF1396).
 

Pathways for Kininogen/Kininostatin/Bradykinin Antibody (AF1396)

View related products by pathway.

Blogs on Kininogen/Kininostatin/Bradykinin

There are no specific blogs for Kininogen/Kininostatin/Bradykinin, but you can read our latest blog posts.
Recombinant Monoclonal Antibodies

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Kininogen/Kininostatin/Bradykinin Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol KNG1
Uniprot
Novus 100% Guarantee