Bradykinin RB1/BDKRB1 Antibody - BSA Free

Immunohistochemistry-Paraffin: Bradykinin RB1/BDKRB1 Antibody [NLS799] - Brain Hippocampus Neurons

Immunohistochemistry-Paraffin: Bradykinin RB1/BDKRB1 Antibody [NLS799] - Analysis of anti-BDKRB1 with human artery, smooth musche, atherosclerosis at dilution 5 ug/ml.

Immunohistochemistry-Paraffin: Bradykinin RB1/BDKRB1 Antibody [NLS799] - Analysis of anti-BDKRB1 antibody with human artery, smooth muscle, atherosclerosis at dilution 5 ug/ml.

• Reactivity: Hu, Pm
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

Bradykinin RB1/BDKRB1 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 16 amino acid peptide from 1st cytoplasmic domain of human Bradykinin RB1/BDKRB1.
• Epitope: 1st cytoplasmic domain
• Localization: Integral membrane protein
• Specificity: Human BDKRB1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: BDKRB1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 2.5-10 ug/ml
  • Western Blot 1:100 - 1:2000
• Application Notes: ELISA: Does not work
• Control:

  Bradykinin RB1/BDKRB1 Overexpression Lysate

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (94%), Gibbon (94%), Equine (81%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Bradykinin RB1/BDKRB1 Antibody - BSA Free

• B1 bradykinin receptor
• B1BKR
• B1R
• BDKRB1
• BK-1 Receptor
• BKB1R
• BKR1
• BRADYB1
• bradykinin B1 receptor
• Bradykinin RB1
• bradykinin receptor 1
• bradykinin receptor B1
• BradykininRB1

Background

Bradykinin Receptor B1 (BKB1) has been implicated in inflammation and nociception. BKB1 receptor is rapidly induced under many inflammatory conditions such as colitis and hyperalgesia, allergic rhinitis, and inflammation. In vitro studies have implicated lipopolysaccharide, interleukins, and interferon as effectors in the rapid induction of BKB1 receptor expression. BKB1 receptor-deficient mice are healthy, fertile, and normotensive but show blunted response to lipopolysaccharide-induced hypotension, reduced migration into inflamed tissues by polymorphonuclear leukocytes, and reduced activity-dependent facilitation of a spinal nociceptive reflex. Bradykinin B1 receptor is generally only minimally expressed under normal physiological conditions, but the expression is induced rapidly under pathologic conditions such as ischemia, atheromatous disease, or exposure to inflammatory cytokines. Expression has been reported in brain, colon, kidney, lung, nasal mucosa, pancreas, prostate, skin, spinal cord, and vessel. ESTs have been isolated from normal human connective tissue libraries and in human kidney and skin cancer libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Bradykinin RB1/BDKRB1 Antibody (NLS799)(1)

Publication using NLS799

• Warman M, Lahav Y, Huszar M et al. Down-Expression of Kinin Receptors in Allergic Nasal Polyps Epithelia: An Immunohistochemistry Study Otolaryngol Head Neck Surg 2020-01-28 [PMID: 31986968]

Bioinformatics

• Gene Symbol: BDKRB1
• Entrez:
  • 623(Human)
• Uniprot:
  • P46663(Human)