KA1/GRIK4/Glutamate Receptor KA1 Antibody

Images

 
Western Blot: KA1/GRIK4/Glutamate Receptor KA1 Antibody [NBP1-76852] - Rat brain tissue lysate with Glutamate receptor KA1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunocytochemistry/ Immunofluorescence: KA1/GRIK4/Glutamate Receptor KA1 Antibody [NBP1-76852] - Immunofluorescence of Grik4 in Human Brain cells with Grik4 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: KA1/GRIK4/Glutamate Receptor KA1 Antibody [NBP1-76852] - Human brain tissue using Glutamate receptor KA1 antibody at 2.5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

KA1/GRIK4/Glutamate Receptor KA1 Antibody Summary

Immunogen
Antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of the human Grik4. The immunogen is located within amino acids 30 - 80 of Grik4.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRIK4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Control Peptide
KA1/GRIK4/Glutamate Receptor KA1 Peptide (NBP1-76852PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for KA1/GRIK4/Glutamate Receptor KA1 Antibody

  • EAA1
  • Excitatory amino acid receptor 1
  • GluK4
  • glutamate receptor KA1
  • Glutamate receptor KA-1
  • glutamate receptor, ionotropic kainate 4
  • glutamate receptor, ionotropic, kainate 4
  • GRIK4
  • KA1
  • KA1GRIK

Background

Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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ICC/IF Video Protocol

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Bioinformatics

Gene Symbol GRIK4
Entrez
Uniprot