Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage).
Fusion protein from the N-terminal region of the NMDAR2C subunit. Accession # Q00961
Specific for endogenous levels of the ~140 kDa NR2C subunit of the NMDA receptor. Also labels the ~180 kDa NR2A and the ~180 kDa NR2B subunits of the NMDA receptor. Immunolabeling is blocked by preadsorption of antibody with the immunogen that was used to generate the antibody.
Test in a species/application not listed above to receive a full credit towards a future purchase.
This antibody cross reacts with both NR2A and NR2B, as such, results in immunohistochemistry are varied.
140 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for NMDAR2C Antibody (NB300-107). (Showing 1 - 1 of 1 FAQs).
We have a note from 2005 on our internal datasheet from Novus stating that this antibody has only been tested for IHC on frozen tissue but I see that the Novus datasheet now lists IHC-P. Can you please confirm whether the antibody has been tested on paraffin-embedded tissue? If yes, is there a specific protocol, in particular for antigen retrieval?
NB300-107 has been validated in mouse for IHC-frozen, but not paraffin embedded sections yet.
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
Review this Product
Be the first to review our NMDAR2C Antibody - Azide and BSA Free and receive a gift card or discount.