Fusion protein from the N-terminal region of the NR2C subunit of rat NMDA receptor.
Specific for the ~140k NR2C subunit of the NMDA receptor. Also labels the ~180k NR2A and the ~180k NR2B subunits of the NMDA receptor. Immunolabeling is blocked by preadsorption of antibody with the immunogen that was used to generate the antibody.
Immunogen affinity purified
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This antibody cross reacts with both NR2A and NR2B, as such, results in immunohistochemistry are varied.
140 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for NMDAR2C Antibody (NB300-107). (Showing 1 - 1 of 1 FAQs).
We have a note from 2005 on our internal datasheet from Novus stating that this antibody has only been tested for IHC on frozen tissue but I see that the Novus datasheet now lists IHC-P. Can you please confirm whether the antibody has been tested on paraffin-embedded tissue? If yes, is there a specific protocol, in particular for antigen retrieval?
NB300-107 has been validated in mouse for IHC-frozen, but not paraffin embedded sections yet.
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