ITM2C Antibody - BSA Free

Western Blot: ITM2C Antibody [NBP2-17001] - Sample (30 ug of whole cell lysate) A: Hela 12% SDS PAGE gel, diluted at 1:1000.

Immunohistochemistry-Paraffin: ITM2C Antibody [NBP2-17001] - MCF7 xenograft, using ITM2C antibody at 1:100 dilution. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.

• Reactivity: Hu, Mu, Rt, Po, Bv, Sh
• Applications: WB, Flow, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

ITM2C Antibody - BSA Free Summary

• Immunogen: Recombinant protein encompassing a sequence within the center region of human ITM2C. The exact sequence is proprietary.
• Localization: Membrane; Single-pass type II membrane protein
• Predicted Species: Mouse (95%), Rat (97%), Porcine (98%), Bovine (97%), Sheep (97%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ITM2C
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry Assay dependent
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Western Blot 1:500-1:3000
• Theoretical MW: 30 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Chicken (81%).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 0.1M Tris-Glycine (pH7), 20% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Antigen Affinity-purified

Alternate Names for ITM2C Antibody - BSA Free

• BRI3
• BRI3E25C
• BRICD2C
• BRICHOS domain containing 2C
• Cerebral protein 14
• E25
• hRPC.1050_D_4
• integral membrane protein 2C
• integral membrane protein 3
• ITM2C
• ITM3
• Transmembrane protein BRI3

Background

Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Bioinformatics

• Gene Symbol: ITM2C
• Uniprot:
  • Q9NQX7(Human)