Parvalbumin Antibody - BSA Free

Images

 
Western Blot: Parvalbumin Antibody [NB120-11427] - WB analysis of rat cerebellum extract.
Immunocytochemistry/ Immunofluorescence: Parvalbumin Antibody [NB120-11427] - Analysis of Parvalbumin using anti-Parvalbumin polyclonal antibody shows staining in U251 Cells. Parvalbumin staining (green), F-Actin ...read more
Immunohistochemistry-Paraffin: Parvalbumin Antibody [NB120-11427] - Stargazin expression is restricted to PV+ interneurons in WT mouse somatosensory cortex (upper row). Somatodendritic stargazin immunoreactivity is lost ...read more
Immunocytochemistry/ Immunofluorescence: Parvalbumin Antibody [NB120-11427] - Analysis of Parvalbumin using anti-Parvalbumin polyclonal antibody shows staining in C6 Cells. Parvalbumin staining (green), F-Actin staining ...read more
Immunocytochemistry/ Immunofluorescence: Parvalbumin Antibody [NB120-11427] - Analysis of Parvalbumin using anti-Parvalbumin polyclonal antibody shows staining in Hela Cells. Parvalbumin staining (green), F-Actin ...read more
Immunohistochemistry-Paraffin: Parvalbumin Antibody [NB120-11427] - Normal biopsies of deparaffinized human cerebellum tissue.
Immunohistochemistry-Paraffin: Parvalbumin Antibody [NB120-11427] - Normal biopsies of deparaffinized human skeletal muscle tissue.
Immunohistochemistry-Paraffin: Parvalbumin Antibody [NB120-11427] - Normal biopsies of deparaffinized human tonsil tissue.

Product Details

Summary
Reactivity Hu, Mu, Rt, FeSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P, IP, IHC-FrFl
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
1.0 mg/ml

Order Details

Parvalbumin Antibody - BSA Free Summary

Immunogen
Parvalbumin Antibody made from purified parvalbumin
Localization
Cytoplasmic and Nuclear
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PVALB
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100 - 1:2000
  • Immunocytochemistry/Immunofluorescence 1:100 - 1:200
  • Immunohistochemistry Free-Floating
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Frozen 1:10 - 1:500
  • Immunohistochemistry-Paraffin 1 ug/ml
  • Immunoprecipitation 5 ug/ml
  • Western Blot 0.1 ug/ml
Application Notes
Use in IHC-FrFl reported in scientific literature (PMID:33515957)
Publications
Read Publications using
NB120-11427 in the following applications:

Reactivity Notes

Use in Feline reported in scientific literature (PMID:10.1016/j.celrep.2021.109083). Mouse reactivity reported in scientific literature (PMID: 24065886). Mouse reactivity reported in scientific literature (PMID:33053349).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Parvalbumin Antibody - BSA Free

  • D22S749
  • MGC116759
  • parvalbumin alpha
  • parvalbumin
  • PV

Background

Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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DBD00
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NB100-1519
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NB120-11427
Species: Hu, Mu, Rt, Fe
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P, IP, IHC-FrFl

Publications for Parvalbumin Antibody (NB120-11427)(18)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Feline.

We have publications tested in 6 applications: Flow, ICC/IF, IHC, IHC-Fr, IHC-FrFl, WB.


Filter By Application
Flow
(1)
ICC/IF
(2)
IHC
(9)
IHC-Fr
(1)
IHC-FrFl
(1)
WB
(1)
All Applications
Filter By Species
Human
(1)
Mouse
(7)
Rat
(7)
Feline
(1)
All Species
Showing Publications 1 - 10 of 18. Show All 18 Publications.
Publications using NB120-11427 Applications Species
Marchisella F, Creutzberg KC, Begni V et al. Exposure to Prenatal Stress Is Associated With an Excitatory/Inhibitory Imbalance in Rat Prefrontal Cortex and Amygdala and an Increased Risk for Emotional Dysregulation Frontiers in cell and developmental biology Jun 1 2021 [PMID: 34141707] (IHC, Rat) IHC Rat
Lewis CM, Ni J, Wunderle T et al. Cortical gamma-band resonance preferentially transmits coherent input Cell reports May 4 2021 [PMID: 33951439] (IHC, Feline) IHC Feline
Annamalai B, Parsons N, Nicholson C et al. Subretinal Rather Than Intravitreal Adeno-Associated Virus-Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage Investigative ophthalmology & visual science Apr 1 2021 [PMID: 33830174] (WB, Mouse) WB Mouse
Gildawie KR, Ryll LM, Hexter JC, et al. A two-hit adversity model in developing rats reveals sex-specific impacts on prefrontal cortex structure and behavior Developmental cognitive neuroscience Jan 27 2021 [PMID: 33515957] (IHC-FrFl, Rat) IHC-FrFl Rat
Chui AJ, Griswold AR, Taabazuing CY et al. Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis Cell Rep Oct 12 2020 [PMID: 33053349] (IHC, Mouse) IHC Mouse
Jorgensen ET, Gonzalez AE, Harkness JH et al. Cocaine memory reactivation induces functional adaptations within parvalbumin interneurons in the rat medial prefrontal cortex Addict Biol Aug 4 2020 [PMID: 32750200]
Hatcher, A, Yu, K Et al. Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model. J Clin Invest May 1 2020 [PMID: 32250339] (Flow, Human)

Details:
Citation using the Alexa Fluor 647 format of this antibody.
Flow Human
Kaczmarczyk L, Bansal V, Rajput A et al. Tagger-A Swiss army knife for multiomics to dissect cell type-specific mechanisms of gene expression in mice PLoS Biol. Aug 1 2019 [PMID: 31393866] (ICC/IF, Mouse) ICC/IF Mouse
Komura H, Kakio S et al. Alzheimer A beta Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAK alpha 3 Neurons by Secretion. iScience Mar 29 2019 [PMID: 30827871] (ICC/IF, Rat) ICC/IF Rat
Slaker ML, Jorgensen ET, Hegarty DM et al. Cocaine Exposure Modulates Perineuronal Nets and Synaptic Excitability of Fast-Spiking Interneurons in the Medial Prefrontal Cortex. eNeuro. Oct 4 2018 [PMID: 30294670] (IHC, Rat) IHC Rat
Show All 18 Publications.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Parvalbumin Antibody (NB120-11427). (Showing 1 - 1 of 1 FAQs).

  1. I am doing research on Neuroscience and I would like to use some antibodies, especially in Western Blots, but I could do other assays: - alpha7 nicotinic cholinergic receptor; - parvalbumin; - calbindin D28K; The preferred reactivity is anti-human and anti-mouse. Do you have these antibodies? Are they in stock? And what about the prizes: How much are they? How much are the shipping costs? Could you make me any offer?
    • We currently have three alpha7 nicotinic cholingergic receptor antibodies available for purchase. Please see this list for our Parvalbumin antibodies. None are currently validated in mouse. I would like to introduce you to our Innovators Reward Program. We have an excelent calbinin D28K antibody that has been validated for use in human and mouse and WB. The pricing and availability of our products depends on your country.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PVALB
Entrez
Uniprot