Parvalbumin Antibody - BSA Free

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Western Blot: Parvalbumin Antibody [NB120-11427] - WB analysis of rat cerebellum extract.
Immunocytochemistry/ Immunofluorescence: Parvalbumin Antibody [NB120-11427] - Analysis of Parvalbumin using anti-Parvalbumin polyclonal antibody shows staining in U251 Cells. Parvalbumin staining (green), F-Actin ...read more
Immunohistochemistry-Paraffin: Parvalbumin Antibody [NB120-11427] - Stargazin expression is restricted to PV+ interneurons in WT mouse somatosensory cortex (upper row). Somatodendritic stargazin immunoreactivity is lost ...read more
Immunocytochemistry/ Immunofluorescence: Parvalbumin Antibody [NB120-11427] - Analysis of Parvalbumin using anti-Parvalbumin polyclonal antibody shows staining in C6 Cells. Parvalbumin staining (green), F-Actin staining ...read more
Immunocytochemistry/ Immunofluorescence: Parvalbumin Antibody [NB120-11427] - Analysis of Parvalbumin using anti-Parvalbumin polyclonal antibody shows staining in Hela Cells. Parvalbumin staining (green), F-Actin ...read more
Immunohistochemistry-Paraffin: Parvalbumin Antibody [NB120-11427] - Normal biopsies of deparaffinized human cerebellum tissue.
Immunohistochemistry-Paraffin: Parvalbumin Antibody [NB120-11427] - Normal biopsies of deparaffinized human skeletal muscle tissue.
Immunohistochemistry-Paraffin: Parvalbumin Antibody [NB120-11427] - Normal biopsies of deparaffinized human tonsil tissue.
Stargazin expression is restricted to PV+ interneurons in WT mouse somatosensory cortex (upper row). Somatodendritic stargazin immunoreactivity is lost in PV+ interneurons in stargazer mouse (lower row). Co-labeling of ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, FeSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IP, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
1.0 mg/ml

Order Details

Parvalbumin Antibody - BSA Free Summary

Immunogen
Parvalbumin Antibody made from purified parvalbumin
Localization
Cytoplasmic and Nuclear
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PVALB
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100 - 1:2000
  • Immunocytochemistry/ Immunofluorescence 1:100 - 1:200
  • Immunohistochemistry Free-Floating reported in scientific literature (PMID 33515957)
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Frozen 1:10 - 1:500
  • Immunohistochemistry-Paraffin 1 ug/ml
  • Immunoprecipitation 5 ug/ml
  • Western Blot 0.1 ug/ml
Publications
Read Publications using
NB120-11427 in the following applications:

Reactivity Notes

Use in Feline reported in scientific literature (PMID:10.1016/j.celrep.2021.109083). Mouse reactivity reported in scientific literature (PMID: 24065886). Mouse reactivity reported in scientific literature (PMID:33053349).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Parvalbumin Antibody - BSA Free

  • D22S749
  • MGC116759
  • parvalbumin alpha
  • parvalbumin
  • PV

Background

Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Parvalbumin Antibody (NB120-11427)(30)

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Feline, Marmoset, Primate.

We have publications tested in 7 applications: FLOW, ICC/IF, IF/IHC, IHC, IHC-Fr, IHC-FrFl, WB.


Filter By Application
FLOW
(1)
ICC/IF
(3)
IF/IHC
(7)
IHC
(1)
IHC-Fr
(6)
IHC-FrFl
(2)
WB
(3)
All Applications
Filter By Species
Human
(1)
Mouse
(12)
Rat
(7)
Feline
(1)
Marmoset
(1)
Primate
(2)
All Species
Showing Publications 1 - 10 of 30. Show All 30 Publications.
Publications using NB120-11427 Applications Species
Sun XY, Liu L, Song YT et al. Two parallel medial prefrontal cortex-amygdala pathways mediate memory deficits via glutamatergic projection in surgery mice Cell reports 2023-06-30 [PMID: 37392387] (IHC, Mouse) IHC Mouse
Obenaus A, Kinney-Lang E, Jullienne A et al. Seeking the Amygdala: Novel Use of Diffusion Tensor Imaging to Delineate the Basolateral Amygdala Biomedicines 2023-02-13 [PMID: 36831071] (IHC-Fr, Rat) IHC-Fr Rat
Li J, Godoy MI, Zhang AJ et al. Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis bioRxiv : the preprint server for biology 2023-02-14 [PMID: 36824905] (IHC-Fr, Mouse) IHC-Fr Mouse
Creutzberg KC, Begni V, Marchisella F et al. Early effects of lurasidone treatment in a chronic mild stress model in male rats Psychopharmacology 2023-02-23 [PMID: 36820870] (ICC/IF, Rat) ICC/IF Rat
Hovhannisyan AH, Lindquist KA, Belugin S et al. Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets bioRxiv : the preprint server for biology 2023-02-12 [PMID: 36798270] (IHC-Fr, Primate, Marmoset)

Details:
Dilution used in IHC-Fr 1:200
IHC-Fr Primate, Marmoset
Spahic H, Parmar P, Miller S et al. Dysregulation of ErbB4 Signaling Pathway in the Dorsal Hippocampus after Neonatal Hypoxia-Ischemia and Late Deficits in PV+ Interneurons, Synaptic Plasticity and Working Memory International Journal of Molecular Sciences 2022-12-28 [PMID: 36613949] (IHC-FrFl, Mouse) IHC-FrFl Mouse
Weimar, HV, HV Investigating the Impacts of Maternal Cannabis Use on Developing Offspring in Rats Thesis 2022-01-01
Wu X, Sosunov AA, Lado W et al. Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex Cell reports 2022-07-19 [PMID: 35858542] (IHC-Fr, Mouse) IHC-Fr Mouse
Ginder DE Impacts of Prenatal Cannabis Exposure on the Medial Prefrontal Cortex in Adulthood Thesis 2023-01-01 (WB, Mouse) WB Mouse
Stevens SR, Longley CM, Ogawa Y et al. Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K(+) channels eLife 2021-06-28 [PMID: 34180393]
Show All 30 Publications.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Parvalbumin Antibody (NB120-11427). (Showing 1 - 1 of 1 FAQs).

  1. I am doing research on Neuroscience and I would like to use some antibodies, especially in Western Blots, but I could do other assays: - alpha7 nicotinic cholinergic receptor; - parvalbumin; - calbindin D28K; The preferred reactivity is anti-human and anti-mouse. Do you have these antibodies? Are they in stock? And what about the prizes: How much are they? How much are the shipping costs? Could you make me any offer?
    • We currently have three alpha7 nicotinic cholingergic receptor antibodies available for purchase. Please see this list for our Parvalbumin antibodies. None are currently validated in mouse. I would like to introduce you to our Innovators Reward Program. We have an excelent calbinin D28K antibody that has been validated for use in human and mouse and WB. The pricing and availability of our products depends on your country.

Secondary Antibodies

 

Isotype Controls

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Research Areas for Parvalbumin Antibody (NB120-11427)

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Blogs on Parvalbumin.

Successful Transplantation of Friedreich Ataxia Induced Pluripotent Stem Cell (iPSC)-Derived Sensory Neurons in Dorsal Root Ganglia of Adult Rodents
Jamshed Arslan, Pharm D, PhD The dorsal root ganglia (DRG) are a collection of cell bodies of sensory nerves carrying sensory information – including nociception, mechanoreception and proprioception – from periphera...  Read full blog post.

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Bioinformatics

Gene Symbol PVALB
Entrez
Uniprot