Parvalbumin Antibody

Images

 
Western Blot: Parvalbumin Antibody [NB120-11427] - WB analysis of rat cerebellum extract.
Immunocytochemistry/ Immunofluorescence: Parvalbumin Antibody [NB120-11427] - Analysis of Parvalbumin using anti-Parvalbumin polyclonal antibody shows staining in U251 Cells. Parvalbumin staining (green), F-Actin ...read more
Immunohistochemistry-Paraffin: Parvalbumin Antibody [NB120-11427] - Stargazin expression is restricted to PV+ interneurons in WT mouse somatosensory cortex (upper row). Somatodendritic stargazin immunoreactivity is lost ...read more
Immunocytochemistry/ Immunofluorescence: Parvalbumin Antibody [NB120-11427] - Analysis of Parvalbumin using anti-Parvalbumin polyclonal antibody shows staining in C6 Cells. Parvalbumin staining (green), F-Actin staining ...read more
Immunocytochemistry/ Immunofluorescence: Parvalbumin Antibody [NB120-11427] - Analysis of Parvalbumin using anti-Parvalbumin polyclonal antibody shows staining in Hela Cells. Parvalbumin staining (green), F-Actin ...read more
Immunohistochemistry-Paraffin: Parvalbumin Antibody [NB120-11427] - Normal biopsies of deparaffinized human cerebellum tissue.
Immunohistochemistry-Paraffin: Parvalbumin Antibody [NB120-11427] - Normal biopsies of deparaffinized human skeletal muscle tissue.
Immunohistochemistry-Paraffin: Parvalbumin Antibody [NB120-11427] - Normal biopsies of deparaffinized human tonsil tissue.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Parvalbumin Antibody Summary

Immunogen
Parvalbumin Antibody made from purified parvalbumin
Localization
Cytoplasmic and Nuclear
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PVALB
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/ml
  • ELISA 1:100 - 1:2000
  • Immunocytochemistry/Immunofluorescence 1:100 - 1:200
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Frozen 1:10 - 1:500
  • Immunohistochemistry-Paraffin 1 ug/ml
  • Immunoprecipitation 5 ug/ml
Application Notes
Western blot detects an approx. 12 kDa band. IHC-Frozen sections usage reported in scientific literature (PMID: 24065886).
Publications
Read Publications using
NB120-11427 in the following applications:

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 24065886).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Parvalbumin Antibody

  • D22S749
  • MGC116759
  • parvalbumin alpha
  • parvalbumin
  • PV

Background

Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NB120-11427
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P, IP

Publications for Parvalbumin Antibody (NB120-11427)(10)

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, IHC, IHC-Fr.


Filter By Application
ICC/IF
(1)
IHC
(5)
IHC-Fr
(1)
All Applications
Filter By Species
Mouse
(4)
Rat
(4)
All Species
Showing Publications 1 - 10 of 10.
Publications using NB120-11427 Applications Species
Kaczmarczyk L, Bansal V, Rajput A et al. Tagger-A Swiss army knife for multiomics to dissect cell type-specific mechanisms of gene expression in mice PLoS Biol. Aug 1 2019 [PMID: 31393866] (ICC/IF, Mouse) ICC/IF Mouse
Cao W, Lin S, Xia QQ et al. Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice. Neuron. Mar 21 2018 [PMID: 29566795] (Mouse) Mouse
Nobili A, Krashia P, Cordella A et al. Ambra1 Shapes Hippocampal Inhibition/Excitation Balance: Role in Neurodevelopmental Disorders. Mol. Neurobiol. Feb 27 2018 [PMID: 29488136] (IHC, Mouse) IHC Mouse
Maheshwari A, Nahm WK, Noebels JL. Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice. Front Cell Neurosci. 2013 Sep 18 [PMID: 24065886] (IHC-Fr, Mouse) IHC-Fr Mouse
Buffington SA, RasbMN. Na+ channel-dependent recruitment of navbeta4 to axon initial segments and nodes of ranvier J Neurosci 2013 Apr 3 [PMID: 23554500] (IHC, Rat) IHC Rat
Xiong H, Xia K, Li B et al. KChIP1: a potential modulator to GABAergic system. gmp013. 2009 [PMID: 19352544]
Obenaus A, Kinney-Lang E, Jullienne A et al. Novel use of Diffusion Tensor Imaging to Delineate the Rat Basolateral Amygdala bioRxiv Oct 10 2018 (IHC, Rat) IHC Rat
Slaker ML, Jorgensen ET, Hegarty DM et al. Cocaine Exposure Modulates Perineuronal Nets and Synaptic Excitability of Fast-Spiking Interneurons in the Medial Prefrontal Cortex. eNeuro. Oct 4 2018 [PMID: 30294670] (IHC, Rat) IHC Rat
Obenaus A, Kinney-Lang E, Jullienne A et al. Novel use of Diffusion Tensor Imaging to Delineate the Rat Basolateral Amygdala Int J Mol Sci Oct 15 2018 (IHC, Rat) IHC Rat
Jorgensen ET, Gonzalez AE, Harkness JH et al. Cocaine memory reactivation induces functional adaptations within parvalbumin interneurons in the rat medial prefrontal cortex Addict Biol Aug 4 2020 [PMID: 32750200]

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Parvalbumin Antibody (NB120-11427). (Showing 1 - 1 of 1 FAQs).

  1. I am doing research on Neuroscience and I would like to use some antibodies, especially in Western Blots, but I could do other assays: - alpha7 nicotinic cholinergic receptor; - parvalbumin; - calbindin D28K; The preferred reactivity is anti-human and anti-mouse. Do you have these antibodies? Are they in stock? And what about the prizes: How much are they? How much are the shipping costs? Could you make me any offer?
    • We currently have three alpha7 nicotinic cholingergic receptor antibodies available for purchase. Please see this list for our Parvalbumin antibodies. None are currently validated in mouse. I would like to introduce you to our Innovators Reward Program. We have an excelent calbinin D28K antibody that has been validated for use in human and mouse and WB. The pricing and availability of our products depends on your country.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB120-11427AF350
Alexa Fluor 405 NB120-11427AF405
Alexa Fluor 488 NB120-11427AF488
Alexa Fluor 532 NB120-11427AF532
Alexa Fluor 594 NB120-11427AF594
Alexa Fluor 647 NB120-11427AF647
Alexa Fluor 700 NB120-11427AF700
Alexa Fluor 750 NB120-11427AF750
Biotin NB120-11427B
DyLight 350 NB120-11427UV
DyLight 405 NB120-11427V
DyLight 488 NB120-11427G
DyLight 550 NB120-11427R
DyLight 594 NB120-11427DL594
DyLight 650 NB120-11427C
DyLight 680 NB120-11427FR
DyLight 755 NB120-11427IR
FITC NB120-11427F
HRP NB120-11427H
Janelia Fluor 549 NB120-11427JF549
Janelia Fluor 646 NB120-11427JF646

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Bioinformatics

Gene Symbol PVALB
Entrez
Uniprot