Integrin beta 2/CD18 Antibody (MEM-48) [Biotin]

Images

 
There are currently no images for Integrin beta 2/CD18 Antibody (NBP1-44612).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
MEM-48
Clonality
Monoclonal
Host
Mouse
Concentration
1 mg/ml

Integrin beta 2/CD18 Antibody (MEM-48) [Biotin] Summary

Immunogen
Leukocytes of a patient suffering from a LGL-type leukemia.
Specificity
The antibody MEM-48 recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit; beta2 integrin). CD18 is a 90-95 kDa type I transmembrane protein expressed on all leukocytes.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGB2
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Conjugate
Biotin
Format
Biotin (A=N/A, E=N/A)
Buffer
TBS (approx. pH 8.0)
Preservative
15mM Sodium Azide
Concentration
1 mg/ml
Purity
Protein A purified

Applications/Dilutions

Alternate Names for Integrin beta 2/CD18 Antibody (MEM-48) [Biotin]

  • 959 beta subunit precursor)10
  • CD18 antigen
  • CD18
  • CD18beta 2
  • cell surface adhesion glycoprotein (LFA-1
  • CR3
  • Integrin beta 2
  • integrin beta-2
  • integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit)
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
  • ITGB2
  • LAD
  • LCAMB
  • leukocyte cell adhesion molecule CD18
  • leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
  • LFA-1 beta
  • LFA-1
  • MAC-1 beta
  • MF17
  • MFI7
  • P150
  • p150,95 beta

Background

CD18, integrin b2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (b2) integrins: aLb2 (CD11a/CD18, LFA-1), aMb2 (CD11b/CD18, Mac-1, CR3), aXb2 (CD11c/CD18) and aDb2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NB110-89474
Species: Hu, Mu, Rt
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
MAB3595
Species: Hu
Applications: WB, Flow
NBP1-84550
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
NB100-524
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, IP, Flow-IC
NBP1-42795
Species: Hu
Applications: WB, Flow, Func, IHC, IHC-Fr, IP
NBP1-19371
Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, ICC/IF, IHC, IHC-P
NB110-97871
Species: Mu
Applications: Flow, IHC, IHC-P, IP
NBP2-25200
Species: Hu
Applications: WB, B/N, Flow, IHC, IHC-Fr
NBP2-22542
Species: Hu
Applications: WB, B/N, Flow, ICC/IF, IHC, IHC-Fr, IP
NBP2-24867
Species: Hu
Applications: Flow, Func, In vitro, In vivo, Flow-CS
NB100-64843
Species: Mu
Applications: Flow, IHC, IHC-Fr
NBP1-44612
Species: Hu
Applications: Flow

Publications for Integrin beta 2/CD18 Antibody (NBP1-44612) (0)

There are no publications for Integrin beta 2/CD18 Antibody (NBP1-44612).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Integrin beta 2/CD18 Antibody (NBP1-44612) (0)

There are no reviews for Integrin beta 2/CD18 Antibody (NBP1-44612). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Integrin beta 2/CD18 Antibody (NBP1-44612) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Integrin beta 2/CD18 Products

Related Products by Gene

Bioinformatics Tool for Integrin beta 2/CD18 Antibody (NBP1-44612)

Discover related pathways, diseases and genes to Integrin beta 2/CD18 Antibody (NBP1-44612). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Integrin beta 2/CD18 Antibody (NBP1-44612)

Discover more about diseases related to Integrin beta 2/CD18 Antibody (NBP1-44612).
 

Pathways for Integrin beta 2/CD18 Antibody (NBP1-44612)

View related products by pathway.

PTMs for Integrin beta 2/CD18 Antibody (NBP1-44612)

Learn more about PTMs related to Integrin beta 2/CD18 Antibody (NBP1-44612).
 

Research Areas for Integrin beta 2/CD18 Antibody (NBP1-44612)

Find related products by research area.

Blogs on Integrin beta 2/CD18.

CD11b/CD18 and Neutrophil-Epithelial Interactions as Targets for Anti-Inflammatory Therapies
The beta-2 integrins, a family of four cell surface transmembrane glycoproteins expressed only on leukocytes, include CD11a/CD18, CD11b/CD18, CD11c/CD18, and CD11d/CD18. They consist of a common beta subunit (CD18) and homologous alpha subunits (CD11a...  Read full blog post.

Contact Information

Product PDFs

Bioinformatics

Gene Symbol ITGB2
Entrez
Uniprot

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NBP1-44612 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought