Integrin beta 2/CD18 Antibody (MEM-48) [Biotin] Summary
Leukocytes of a patient suffering from a LGL-type leukemia.
The antibody MEM-48 recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit; beta2 integrin). CD18 is a 90-95 kDa type I transmembrane protein expressed on all leukocytes.
Protein A purified
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Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Biotin (A=N/A, E=N/A)
TBS (approx. pH 8.0)
15mM Sodium Azide
Protein A purified
Alternate Names for Integrin beta 2/CD18 Antibody (MEM-48) [Biotin]
- 959 beta subunit precursor)10
- CD18 antigen
- CD18beta 2
- cell surface adhesion glycoprotein (LFA-1
- Integrin beta 2
- integrin beta-2
- integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit)
- integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
- leukocyte cell adhesion molecule CD18
- leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
- LFA-1 beta
- MAC-1 beta
- p150,95 beta
CD18, integrin b2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (b2) integrins: aLb2 (CD11a/CD18, LFA-1), aMb2 (CD11b/CD18, Mac-1, CR3), aXb2 (CD11c/CD18) and aDb2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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