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Integrin alpha 2b/CD41 Antibody (M148) - BSA Free

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, IP, CyTOF-ready, ICC/IF
Clone
M148
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
BSA Free
Concentration
1 mg/ml

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-2614AF350
Alexa Fluor 405
NB100-2614AF405
Alexa Fluor 488
NB100-2614AF488
Alexa Fluor 532
NB100-2614AF532
Alexa Fluor 594
NB100-2614AF594
Alexa Fluor 647
NB100-2614AF647
Alexa Fluor 700
NB100-2614AF700
Alexa Fluor 750
NB100-2614AF750
Allophycocyanin
NB100-2614APC
Allophycocyanin/Cy7
NB100-2614APCCY7
Biotin
NB100-2614B
DyLight 350
NB100-2614UV
DyLight 405
NB100-2614V
DyLight 550
NB100-2614R
DyLight 594
NB100-2614DL594
DyLight 650
NB100-2614C
DyLight 680
NB100-2614FR
DyLight 755
NB100-2614IR
FITC
NB100-2614F
HRP
NB100-2614H
Janelia Fluor 549
NB100-2614JF549
Janelia Fluor 646
NB100-2614JF646
PE/Atto594
NB100-2614PEATT594
PE/Cy5.5
NB100-2614PECY55
PE/Cy7
NB100-2614PECY7
PerCP
NB100-2614PCP
View Available Formulations
Catalog# & Formulation Size Price
BSA Free
NB100-2614-0.025mg
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Integrin alpha 2b/CD41 Antibody (M148) - BSA Free Summary

Immunogen
Homogenized human medulloblastoma tissue.
Localization
Cell Membrane
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGA2B
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 1:10 - 1:1000
  • Immunofluorescence 1:10 - 1:500
  • Immunohistochemistry 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
Application Notes
M148 inhibits ADP-induced fibrinogen binding and platelet aggregation (Jones et al., 1984). This antibody is CyTOF ready.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Protein A purified

Notes

Positive control(s): human platelets and megakaryocytes.

Alternate Names for Integrin alpha 2b/CD41 Antibody (M148) - BSA Free

  • CD41 antigen
  • CD41
  • CD41BHPA3
  • GP2B
  • GP2Bintegrin alpha-IIb
  • GPalpha IIb
  • GPIIb
  • GTA
  • HPA3
  • Integrin alpha 2b
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41)
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B)
  • ITGA2b
  • ITGAB
  • platelet fibrinogen receptor, alpha subunit
  • Platelet membrane glycoprotein IIb
  • platelet-specific antigen BAK

Background

Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NB100-524
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Integrin alpha
2b/CD41 Antibody (M14 ...
NB100-2614
Integrin alpha 2b/CD41 Antibody (M148) - BSA Free
Species: Hu
Applications: Flow, IHC, IP, CyTOF-ready, ICC/IF

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Bioinformatics

Gene Symbol ITGA2B
Entrez