Integrin alpha 2b/CD41 Antibody (M148) [DyLight 350]

• Reactivity: Hu
• Applications: Flow, IHC, IP, CyTOF-ready, ICC/IF
• Clone: M148
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 350

Integrin alpha 2b/CD41 Antibody (M148) [DyLight 350] Summary

• Description: This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
• Immunogen: Homogenized human medulloblastoma tissue.
• Localization: Cell Membrane
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ITGA2B
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Immunofluorescence
  • Immunohistochemistry
  • Immunoprecipitation
• Application Notes: Optimal dilution of this antibody should be experimentally determined. Positive control(s): human platelets and megakaryocytes.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Integrin alpha 2b/CD41 Antibody (M148) [DyLight 350]

• CD41 antigen
• CD41
• CD41BHPA3
• GP2B
• GP2Bintegrin alpha-IIb
• GPalpha IIb
• GPIIb
• GTA
• HPA3
• Integrin alpha 2b
• integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41)
• integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B)
• ITGA2b
• ITGAB
• platelet fibrinogen receptor, alpha subunit
• Platelet membrane glycoprotein IIb
• platelet-specific antigen BAK

Background

Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin alpha 2b/CD41 Antibody (NB100-2614UV)(1)

Publication using NB100-2614UV

• Shea SM, Thomas KA, Rassam RMG Et al. Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion Pharmaceuticals (Basel) 2022-12-23 [PMID: 36558901] (ICC/IF, Human)
  
  Details:
  Citation using the Janelia Fluor 646 version of this antibody.

Bioinformatics

• Gene Symbol: ITGA2B
• Entrez:
  • 3674(Human)
  • 16399(Mouse)
  • 29350(Rat)