IL-4 Antibody (BVD4-1D11)

Images

 
Western Blot: IL-4 Antibody (BVD4-1D11) [NB100-64798] - Analysis of mouse IL-4 recombinant protein probed with RAT ANTI MOUSE INTERLEUKIN-4 followed by F(ab')2 RABBIT ANTI RAT IgG:HRP.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, ELISA, Flow, IHC, IHC-Fr
Clone
BVD4-1D11
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
1.0 mg/ml

IL-4 Antibody (BVD4-1D11) Summary

Immunogen
Recombinant Mouse IL-4
Specificity
This is specific for mouse Interleukin-4 (IL-4). Interleukin-4 is a potent lymphoid growth factor, which stimulates the growth and survival of certain B and T cells. Clone BVD4-1D11 is reported to neutralise the effects of mouse IL-4 (3).
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
IL4
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml-5 ug/ml
  • ELISA 1 ug/ml-5 ug/ml
  • Flow Cytometry 1:10-1:50
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Phosphate buffered saline
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A or G purified

Alternate Names for IL-4 Antibody (BVD4-1D11)

  • B cell growth factor 1
  • BCDF
  • B-cell stimulatory factor 1
  • BCGF1
  • BCGF-1
  • binetrakin
  • BSF1
  • BSF-1
  • IL4
  • IL-4
  • IL-4B_cell stimulatory factor 1
  • interleukin 4
  • interleukin-4
  • Lymphocyte stimulatory factor 1
  • MGC79402
  • pitrakinra

Background

IL4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of native CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB100-64798AF405
Alexa Fluor 488 Labeled NB100-64798AF488
Alexa Fluor 647 Labeled NB100-64798AF647
Alexa Fluor 700 Labeled NB100-64798AF700
Allophycocyanin Labeled NB100-64798APC
DyLight 350 Labeled NB100-64798UV
DyLight 405 Labeled NB100-64798V
DyLight 488 Labeled NB100-64798G
DyLight 680 Labeled NB100-64798FR
DyLight 755 Labeled NB100-64798IR
PE Labeled NB100-64798PE
PerCP Labeled NB100-64798PCP

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Bioinformatics

Gene Symbol IL4
Entrez
Uniprot