IKEPP Antibody - BSA Free

Immunohistochemistry-Paraffin: IKEPP Antibody [NBP3-17195] - Staining of human stomach shows strong cytoplasmic and membranous positivity in glandular cells.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

IKEPP Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit IKEPP Antibody - BSA Free (NBP3-17195) is a polyclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: PSTLSGHRVCQAHGEPVLGLCPLLPLFCCPPHPPDPWSLERPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDV
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NHERF4
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:1000 - 1:2500
  • Immunohistochemistry-Paraffin 1:1000 - 1:2500
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.2, 40% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for IKEPP Antibody - BSA Free

• FLJ22756
• IKEPPPDZK2
• intestinal and kidney enriched PDZ protein
• Intestinal and kidney-enriched PDZ protein
• Na(+)/H(+) exchange regulatory cofactor NHE-RF4
• Na/Pi cotransporter C-terminal-associated protein 2
• naPi-Cap2
• Natrium-phosphate cotransporter IIa C-terminal-associated protein 2
• NHERF4
• NHERF-4
• PDZ domain containing 2
• PDZ domain containing 3
• PDZ domain-containing protein 2
• PDZ domain-containing protein 3
• Sodium-hydrogen exchanger regulatory factor 4

Background

IKEPP, also known as PDZD3, associates with GUCY2C to act as a regulatory protein and negatively modulates the heat-stable enterotoxin-mediated activation of GUCY2C. Specifically, IKEPP regulates the amount of cGMP produced following receptor stimulation. IKEPP has also been found to stimulate SLC9A3 activity in the presence of elevated calcium ions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NHERF4