Human Resistin Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human Resistin Quantikine ELISA Kit Summary

• Background: The Quantikine Human Resistin Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human Resistin in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human Resistin and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Resistin showed linear curves that were parallel to the standard curves obtained... using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring Resistin.
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• Specificity: Natural and recombinant human Resistin
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: RETN

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Resistin Quantikine ELISA Kit

• Adipose tissue-specific secretory factor
• ADSF
• ADSFMGC126609
• C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich proteinprecursor 1
• C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
• Cysteine-rich secreted protein A12-alpha-like 2
• Cysteine-rich secreted protein FIZZ3
• FIZZ3
• FIZZ3MGC126603
• found in inflammatory zone 3
• HXCP1
• Resistin
• RETN
• RETN1
• RSTNXCP1

Background

Resistin, also known ADSF and FIZZ3, is a secreted peptide hormone that circulates as either a noncovalent trimer, or a disulfide-linked homohexamer. Resistin is expressed by white adipocytes, splenocytes, astrocytes, and anterior pituitary epithelium. It blocks Insulin-stimulated uptake of glucose by adipocytes and promotes glucose release by hepatocytes. High circulating Insulin levels induce Resistin secretion which then antagonize Insulin action.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Resistin (DRSN00)(36)

Publications using DRSN00

• K Wolk, D Wilsmann-T, K Witte, TC Brembach, C Kromer, S Gerdes, K Ghoreschi, K Reich, R Mössner, R Sabat Interleukin-19 Levels Are Increased in Palmoplantar Pustulosis and Reduced following Apremilast Treatment International Journal of Molecular Sciences, 2023;24(2):. 2023 [PMID: 36674793]
• M Rachwalik, M Matusiewic, M Jasi?ski, M Hurkacz Evaluation of the usefulness of determining the level of selected inflammatory biomarkers and resistin concentration in perivascular adipose tissue and plasma for predicting postoperative atrial fibrillation in patients who underwent myocardial revascularisation Lipids in Health and Disease, 2023;22(1):2. 2023 [PMID: 36624488] (Human)
• YY Wang, AC Hung, YC Wu, S Lo, HD Chen, YK Chen, YC Hsieh, SC Hu, MF Hou, SF Yuan ADSCs stimulated by resistin promote breast cancer cell malignancy via CXCL5 in a breast cancer coculture model Scientific Reports, 2022;12(1):15437. 2022 [PMID: 36104403] (Human)
• M Dreiner, T Munk, F Zaucke, AM Liphardt, A Niehoff Relationship between different serum cartilage biomarkers in the acute response to running and jumping in healthy male individuals Scientific Reports, 2022;12(1):6434. 2022 [PMID: 35440750] (Human)
• AS Bonavia, ZC Chroneos, V Ruiz-Velas, CH Lang Resistin production does not affect outcomes in a mouse model of acute surgical sepsis PLoS ONE, 2022;17(3):e0265241. 2022 [PMID: 35286340] (Human)
• N Šebunova, J Štšepetova, T Kullisaar, K Suija, A Rätsep, I Junkin, H Soeorg, M Lember, T Sillakivi, R Mändar Changes in adipokine levels and metabolic profiles following bariatric surgery BMC endocrine disorders, 2022;22(1):33. 2022 [PMID: 35114975] (Human)
• X Peng, J Huang, H Zou, B Peng, S Xia, K Dong, N Sun, J Tao, Y Yang Roles of plasma leptin and resistin in novel subgroups of type 2 diabetes driven by cluster analysis Lipids in Health and Disease, 2022;21(1):7. 2022 [PMID: 34996484] (Human)
• V Nagl, B Grenier, P Pinton, U Ruczizka, M Dippel, M Bünger, IP Oswald, L Soler Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs Toxins, 2021;13(11):. 2021 [PMID: 34822574] (Porcine)
• A Stochmal, A Wa?kiel-Bu, S Chrostowsk, M Zaremba, A Rakowska, J Czuwara, L Rudnicka Adiponectin as a novel biomarker of disease severity in alopecia areata Scientific Reports, 2021;11(1):13809. 2021 [PMID: 34226603] (Human)
• I Olejniczak, J Narbutt, J Ceryn, M Skibi?ska, I Bednarski, A Wo?niacka, J Sieniawska, M Kraska-Gac, M Ci??y?ska, J ?migielski, M Noweta, M Waszczykow, W Owczarek, A Reich, A Lesiak AntiTNF-alpha therapy normalizes levels of lipids and adipokines in psoriatic patients in the real-life settings Scientific Reports, 2021;11(1):9289. 2021 [PMID: 33927259] (Human)
• T P?atek, A Polus, J Góralska, U Ra?ny, A Dziewo?ska, A Micek, A Dembi?ska-, B Solnica, M Malczewska Epigenetic Regulation of Processes Related to High Level of Fibroblast Growth Factor 21 in Obese Subjects Genes, 2021;12(2):. 2021 [PMID: 33670024] (Human)
• GK Vasileiadi, AC Lundell, Y Zhang, K Andersson, I Gjertsson, A Rudin, C Maglio Adipocytokines in Untreated Newly Diagnosed Rheumatoid Arthritis: Association with Circulating Chemokines and Markers of Inflammation Biomolecules, 2021;11(2):. 2021 [PMID: 33669910] (Human)
• YZ Chen, SQ Zhou, YQ Chen, H Peng, YG Zhuang Plasma Adipokines in Patients Resuscitated from Cardiac Arrest: Difference of Visfatin between Survivors and Nonsurvivors Dis. Markers, 2020;2020(0):9608276. 2020 [PMID: 32015774] (Human)
• M Rachwalik, M Obremska, D Zy?ko, M Matusiewic, K ?ciborski, M Jasi?ski The concentration of resistin in perivascular adipose tissue after CABG and postoperative atrial fibrillation BMC Cardiovasc Disord, 2019;19(1):294. 2019 [PMID: 31842758] (Human)
• S Chauhan, K Dunlap, LK Duffy Effects of Methylmercury and Theaflavin Digallate on Adipokines in Mature 3T3-L1 Adipocytes Int J Mol Sci, 2019;20(11):. 2019 [PMID: 31195622] (Mouse)
• Z He, Y Tian, PL Valenzuela, C Huang, J Zhao, P Hong, Z He, S Yin, A Lucia Myokine/Adipokine Response to "Aerobic" Exercise: Is It Just a Matter of Exercise Load? Front Physiol, 2019;10(0):691. 2019 [PMID: 31191366] (Human)
• AD Farca?, A Rusu, MA Stoia, LA Vida-Simit Plasma leptin, but not resistin, TNF-? and adiponectin, is associated with echocardiographic parameters of cardiac remodeling in patients with coronary artery disease Cytokine, 2018;103(0):46-49. 2018 [PMID: 29324260] (Human)
• J Kocot, P Dziemidok, M Kie?czykow, J Kurzepa, G Szcze?niak, I Musik Is There Any Relationship between Plasma 25-Hydroxyvitamin D?, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients? Int J Environ Res Public Health, 2017;15(1):. 2017 [PMID: 29295491] (Human)
• M Solis-Pare, G Estrada-Gu, O Perichart-, A Montoya-Es, M Guzmán-Hue, H Borboa-Oli, E Bravo-Flor, A Cardona-Pé, V Zaga-Clave, E Garcia-Lat, G Gonzalez-P, JA Hernández-, C Irles Key Clinical Factors Predicting Adipokine and Oxidative Stress Marker Concentrations among Normal, Overweight and Obese Pregnant Women Using Artificial Neural Networks Int J Mol Sci, 2017;19(1):. 2017 [PMID: 29283404] (Human)
• M ?ciskalska, G Marek, Z Grzebienia, H Milnerowic Resistin as a Prooxidant Factor and Predictor of Endothelium Damage in Patients with Mild Acute Pancreatitis Exposed to Tobacco Smoke Xenobiotics Mediators Inflamm., 2017;2017(0):3039765. 2017 [PMID: 29081601] (Human)
• S Vachatova, C Andrys, J Krejsek, M Salavec, K Ettler, V Rehacek, E Cermakova, A Malkova, Z Fiala, L Borska Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients J Immunol Res, 2016;2016(0):5380792. 2016 [PMID: 28097156] (Human)
• Circadian misalignment increases cardiovascular disease risk factors in humans Proc. Natl. Acad. Sci. U.S.A., 2016;113(10):E1402-11. 2016 [PMID: 26858430] (Human)
• Mera K, Uto H, Mawatari S, Ido A, Yoshimine Y, Nosaki T, Oda K, Tabu K, Kumagai K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Hidaka M, Eguchi S, Tsubouchi H Serum levels of apoptosis inhibitor of macrophage are associated with hepatic fibrosis in patients with chronic hepatitis C. BMC Gastroenterol, 2014;14(0):27. 2014 [PMID: 24524410] (Human)
• Tierney AC, McMonagle J, Shaw DI, Gulseth HL, Helal O, Saris WH, Paniagua JA, Golabek-Leszczynska I, Defoort C, Williams CM, Karsltrom B, Vessby B, Dembinska-Kiec A, Lopez-Miranda J, Blaak EE, Drevon CA, Gibney MJ, Lovegrove JA, Roche HM Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome-LIPGENE: a European randomized dietary intervention study. Int J Obes (Lond), 2011;35(6):800-9. 2011 [PMID: 20938439] (Human)
• Bunck MC, Diamant M, Eliasson B, Corner A, Shaginian RM, Heine RJ, Taskinen MR, Yki-Jarvinen H, Smith U Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition. Diabetes Care, 2010;33(8):1734-7. 2010 [PMID: 20424219] (Human)
• Al-Lahham SH, Roelofsen H, Priebe M, Weening D, Dijkstra M, Hoek A, Rezaee F, Venema K, Vonk RJ Regulation of adipokine production in human adipose tissue by propionic acid. Eur. J. Clin. Invest., 2010;40(5):401-7. 2010 [PMID: 20353437] (Human)
• Bhutani S, Klempel MC, Berger RA, Varady KA Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations. Obesity (Silver Spring), 2010;18(11):2152-9. 2010 [PMID: 20300080] (Human)
• Frankel DS, Vasan RS, D'Agostino RB, Benjamin EJ, Levy D, Wang TJ, Meigs JB Resistin, adiponectin, and risk of heart failure the Framingham offspring study. J. Am. Coll. Cardiol., 2009;53(9):754-62. 2009 [PMID: 19245965] (Human)
• Hu WL, Qian SB, Li JJ Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin. Cytokine, 2007;40(3):201-6. 2007 [PMID: 18023360] (Human)
• Golledge J, Clancy P, Jamrozik K, Norman PE Obesity, adipokines, and abdominal aortic aneurysm: Health in Men study. Circulation, 2007;116(20):2275-9. 2007 [PMID: 17967974] (Human)
• Ruano J, Lopez-Miranda J, de la Torre R, Delgado-Lista J, Fernandez J, Caballero J, Covas MI, Jimenez Y, Perez-Martinez P, Marin C, Fuentes F, Perez-Jimenez F Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients. Am. J. Clin. Nutr., 2007;86(2):341-6. 2007 [PMID: 17684203] (Human)
• Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J. Clin. Invest., 2007;117(8):2289-301. 2007 [PMID: 17641777] (Human)
• Wang TD, Chen WJ, Cheng WC, Lin JW, Chen MF, Lee YT Relation of improvement in endothelium-dependent flow-mediated vasodilation after rosiglitazone to changes in asymmetric dimethylarginine, endothelin-1, and C-reactive protein in nondiabetic patients with the metabolic syndrome. Am. J. Cardiol., 2006;98(8):1057-62. 2006 [PMID: 17027571] (Human)
• Fagerberg B, Fagerlund C, Hulthe J Resistin and GFR. Kidney Int., 2006;70(7):1371. 2006 [PMID: 16988732] (Human)
• Tubbs KA, Kiernan UA, Niederkofler EE Development of recombinant-based mass spectrometric immunoassay with application to resistin expression profiling. Anal. Chem., 2006;78(10):3271-6. 2006 [PMID: 16689526] (Human)
• Chan DC, Watts GF, Ng TW, Uchida Y, Sakai N, Yamashita S, Barrett PH Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism. Clin. Chem., 2005;51(3):578-85. 2005 [PMID: 15650029] (Human)

Bioinformatics

• Gene Symbol: RETN