Human/Mouse BDNF DuoSet ELISA, 15 Plate



Product Details

Reactivity Hu, MuSpecies Glossary
Applications ELISA

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Human/Mouse BDNF DuoSet ELISA, 15 Plate Summary

Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
No significant interference observed with available related molecules.
Read Publications using DY248.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human/Mouse BDNF DuoSet ELISA, 15 Plate

  • Abrineurin
  • ANON2
  • BDNF
  • brain-derived neurotrophic factor
  • BULN2
  • MGC34632
  • Neurotrophin


BDNF (Brain-Derived Neurotrophic Factor) is a secreted protein that regulates many aspects of neuronal development and function in the nervous system. It is produced as proBDNF in response to neuronal activity or inflammatory stimulation and is then cleaved before associating into a homodimer. It is expressed throughout the nervous system as well as by fibroblasts, megakaryocytes/platelets, and smooth muscle cells. BDNF regulates neural stem cell survival and differentiation, axon/dendrite differentiation, synapse formation and maturation, and refinement of developing circuits. It is also a key regulator of synaptic plasticity and late-phase long-term potentiation. BDNF signals through the TrkB and NGF R/TNFRSF16 receptors. Secreted proBDNF can bind to NGF R/TNFRSF16 and induce long-term depression and cell apoptosis.

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Applications: CyTOF-ready, Flow, IHC, Neut, WB
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Publications for BDNF (DY248)(51)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, N/A.

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Showing Publications 1 - 10 of 51. Show All 51 Publications.
Publications using DY248 Applications Species
K Boyé, LH Geraldo, J Furtado, L Pibouin-Fr, M Poulet, D Kim, B Nelson, Y Xu, L Jacob, N Maissa, D Agalliu, L Claesson-W, SL Ackerman, A Eichmann Endothelial Unc5B controls blood-brain barrier integrity Nature Communications, 2022;13(1):1169. 2022 [PMID: 35246514] (Mouse) Mouse
T Behrendt, F Kirschnick, L Kröger, P Beileke, M Rezepin, T Brigadski, V Le beta mann, L Schega Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults Bmc Neuroscience, 2021;22(1):71. 2021 [PMID: 34823469] (Human) Human
SP Woods, JL Thompson, MA Babicz, L Shahani, GD Colpo, NP Rocha, EE Morgan, AL Teixeira Apathy is not associated with a panel of biomarkers in older adults with HIV disease Journal of psychosomatic research, 2021;152(0):110666. 2021 [PMID: 34768029] (Human) Human
M Lale Ataei, M Karimipour, P Shahabi, R Pashaei-As, E Ebrahimie, M Pashaiasl The Restorative Effect of Human Amniotic Fluid Stem Cells on Spinal Cord Injury Cells, 2021;10(10):. 2021 [PMID: 34685545] (Rat) Rat
P Rosso, E Fico, LA Mesentier-, V Triaca, A Lambiase, P Rama, P Tirassa NGF Eye Administration Recovers the TrkB and Glutamate/GABA Marker Deficit in the Adult Visual Cortex Following Optic Nerve Crush International Journal of Molecular Sciences, 2021;22(18):. 2021 [PMID: 34576177] (Rat) Rat
NM Gervasi, A Dimtchev, DM Clark, M Dingle, AV Pisarchik, LJ Nesti C-terminal domain small phosphatase 1 (CTDSP1) regulates growth factor expression and axonal regeneration in peripheral nerve tissue Scientific Reports, 2021;11(1):14462. 2021 [PMID: 34262056] (Human) Human
YZ Le, B Xu, AJ Chucair-El, H Zhang, M Zhu VEGF Mediates Retinal M�ller Cell Viability and Neuroprotection through BDNF in Diabetes Biomolecules, 2021;11(5):. 2021 [PMID: 34068807] (Rat) Rat
G Fiorilli, F Quinzi, A Buonsenso, G Casazza, L Manni, A Parisi, A Di Costanz, G Calcagno, M Soligo, A di Cagno A Single Session of Whole-Body Electromyostimulation Increases Muscle Strength, Endurance and proNGF in Early Parkinson Patients International Journal of Environmental Research and Public Health, 2021;18(10):. 2021 [PMID: 34065571] (Human) Human
HL Lee, CE Yeum, H Lee, J Oh, JT Kim, WJ Lee, Y Ha, YI Yang, KN Kim Peripheral Nerve-Derived Stem Cell Spheroids Induce Functional Recovery and Repair after Spinal Cord Injury in Rodents International Journal of Molecular Sciences, 2021;22(8):. 2021 [PMID: 33923671] (Human) Human
V Demers-Mat, DJ Hines, RM Hines, S Lavangnana, S Fels, E Medo Influence of Previous COVID-19 and Mastitis Infections on the Secretion of Brain-Derived Neurotrophic Factor and Nerve Growth Factor in Human Milk International Journal of Molecular Sciences, 2021;22(8):. 2021 [PMID: 33917718] (Human) Human
Show All 51 Publications.

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Blogs on BDNF. Showing 1-10 of 11 blog posts - Show all blog posts.

  Read full blog post.

The use of a GFP antibody for research applications in transgenic C. elegans, GFP tagged yeast and porcine model
GFP, or green fluorescent protein, is a chemiluminescent protein derived from Aequorea jellyfish that was first discovered by Osamu Shimomura.  It was soon after established that the emission spectra of GFP was right around 509nm, or the ultraviol...  Read full blog post.

The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2
Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...  Read full blog post.

Niemann Pick-C1 and cholesterol dynamics
Niemann-Pick type C1 (NPC1) mediates low-density cholesterol transport from late endosomes and lysosomes to other areas of the cell via receptor mediation endocytosis.  Although cholesterol moves freely inside the cell, it cannot independently expo...  Read full blog post.

Synapsin I: Implicated in synaptic activity across a diverse range of studies
Synapsins are a family of neuronal proteins that are most renowned for their activity in modulating the pre-synaptic terminal.  Synapsin’s behavior is regulated by protein kinases and phosphatases, which alter the way that synapsin’s i...  Read full blog post.

TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its ...  Read full blog post.

TrkB and Nervous System Function
Neutrophins and their receptors play an important role in regulating the development of both the central and peripheral nervous systems. Neurotrophin ligand binding to each of their respective Trk cellular receptors is essential for the growth and sur...  Read full blog post.

TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...  Read full blog post.

BDNF Antibodies Aid Research on Alzheimer's Therapies
Brain-derived neurotrophic factor (BDNF) is known to be important for neuronal differentiation, survival, migration and plasticity in both the developing embryo and adult synapses. The BDNF antibody is also proving to be an important tool in Alzheimer...  Read full blog post.

BDNF Antibodies and Synaptic Research
Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophins. During development it regulates the survival and differentiation of neuronal cell populations in the central and peripheral nervous system, while in adult synapse...  Read full blog post.

Showing 1-10 of 11 blog posts - Show all blog posts.

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Gene Symbol BDNF