Human Follistatin Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Human Follistatin Quantikine ELISA Kit Summary

Background
The Quantikine Human Follistatin Immunoassay is a 5.5 hour solid-phase ELISA designed to measure human Follistatin (FS288, FS300, and FS315) in follicular fluid, cell culture supernates, serum, and plasma. It contains Sf 21-expressed recombinant human Follistatin and antibodies raised against the recombinant factor. It has been shown to accurately quantitate recombinant human Follis...tatin. Results obtained using natural Follistatin showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural Follistatin.
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Specificity
Natural and recombinant human Follistatin
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
FST

Applications/Dilutions

Application Notes
Interference observed with 1 or more available related molecules.
Publications
Read Publications using DFN00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Follistatin Quantikine ELISA Kit

  • follistatin isoform FST317
  • Follistatin
  • FS
  • FSActivin-binding protein
  • FST

Background

Follistatin (FST) is a secreted glycoprotein that binds and neutralizes several TGF-beta superfamily proteins including Activin, BMP-6, BMP-7, and GDF-8/Myostatin. It also binds Angiogenin and regulates hematopoietic stem cell adhesion to Fibronectin. Some Follistatin binding partners will also bind Follistatin-like proteins such as FSL-3. Of three follistatin isoforms, the full-length mature follistatin (FST315) is the most abundant and the sole form in plasma, but has lower binding affinity for both activins and heparins than alternative forms. The acidic tail is missing in the splice variant FST288, which shows highest affinity, and partial in the proteolytically produced FST303, which shows intermediate affinity. Genetic deletion of follistatin in mice, or expression of only the FST288 form, is lethal perinatally due to defects of lung, skin and musculoskeletal system. Expression of only the FST315 isoform allows survival, with defects in vascularization and female fertility.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Follistatin (DFN00)(25)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Rat.


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Human
(17)
Mouse
(6)
Rat
(1)
Transgenic Rat
(1)
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Showing Publications 1 - 10 of 25. Show All 25 Publications.
Publications using DFN00 Applications Species
S Sarcar, W Tulalamba, MY Rincon, J Tipanee, HQ Pham, H Evens, D Boon, E Samara-Kuk, M Keyaerts, M Loperfido, E Berardi, S Jarmin, P In't Veld, G Dickson, T Lahoutte, M Sampaolesi, P De Bleser, T VandenDrie, MK Chuah Next-generation muscle-directed gene therapy by in silico vector design Nat Commun, 2019;10(1):492. 2019 [PMID: 30700722] (Mouse) Mouse
Z He, Y Tian, PL Valenzuela, C Huang, J Zhao, P Hong, Z He, S Yin, A Lucia Myokine Response to High-Intensity Interval vs. Resistance Exercise: An Individual Approach Front Physiol, 2018;9(0):1735. 2018 [PMID: 30559681] (Human) Human
E Fife, J Kostka, ? Kroc, A Guligowska, M Pig?owska, B So?tysik, A Kaufman-Sz, K Fabianowsk, T Kostka Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men BMC Geriatr, 2018;18(1):200. 2018 [PMID: 30165829] (Human) Human
R Tao, C Wang, O Stöhr, W Qiu, Y Hu, J Miao, XC Dong, S Leng, M Stefater, N Stylopoulo, L Lin, KD Copps, MF White Inactivating hepatic follistatin alleviates hyperglycemia Nat. Med., 2018;0(0):. 2018 [PMID: 29867232] (Mouse) Mouse
J Ma, C Pichavant, H du Bois, M Bhakta, MP Calos DNA-Mediated Gene Therapy in a Mouse Model of Limb Girdle Muscular Dystrophy 2B Mol Ther Methods Clin Dev, 2017;7(0):123-131. 2017 [PMID: 29159199] (Mouse) Mouse
BT Elliott, P Herbert, N Sculthorpe, FM Grace, D Stratton, LD Hayes Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a�preliminary investigation Physiol Rep, 2017;5(13):. 2017 [PMID: 28701523] (Human) Human
K Ikeda, A Ito, R Imada, M Sato, Y Kawabe, M Kamihira In vitro drug testing based on contractile activity of C2C12 cells in an epigenetic drug model Sci Rep, 2017;7(0):44570. 2017 [PMID: 28300163] (Human) Human
Stelios Loukides Activin A and follistatin in patients with asthma. Does severity make the difference? Respirology, 2016;0(0):. 2016 [PMID: 27807906] (Human) Human
Wilson C, Ottewell P, Coleman R, Holen I The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway. BMC Cancer, 2015;15(0):55. 2015 [PMID: 25884855] (Human) Human
Naf S, Escote X, Ballesteros M, Yanez R, Simon-Muela I, Gil P, Albaiges G, Vendrell J, Megia A Serum activin A and follistatin levels in gestational diabetes and the association of the Activin A-Follistatin system with anthropometric parameters in offspring. PLoS ONE, 2014;9(4):e92175. 2014 [PMID: 24763182] (Human) Human
Show All 25 Publications.

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Product General Protocols

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FAQs for Follistatin (DFN00). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DFN00

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Bioinformatics

Gene Symbol FST