Human Follistatin Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Human Follistatin Quantikine ELISA Kit Summary

Background
The Quantikine Human Follistatin Immunoassay is a 5.5 hour solid-phase ELISA designed to measure human Follistatin (FS288, FS300, and FS315) in follicular fluid, cell culture supernates, serum, and plasma. It contains Sf 21-expressed recombinant human Follistatin and antibodies raised against the recombinant factor. It has been shown to accurately quantitate recombinant human Follis...tatin. Results obtained using natural Follistatin showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural Follistatin.
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Specificity
Natural and recombinant human Follistatin
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
FST

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
Interference observed with 1 or more available related molecules.
Publications
Read Publications using DFN00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Follistatin Quantikine ELISA Kit

  • follistatin isoform FST317
  • Follistatin
  • FS
  • FSActivin-binding protein
  • FST

Background

Follistatin (FST) is a secreted glycoprotein that binds and neutralizes several TGF-beta superfamily proteins including Activin, BMP-6, BMP-7, and GDF-8/Myostatin. It also binds Angiogenin and regulates hematopoietic stem cell adhesion to Fibronectin. Some Follistatin binding partners will also bind Follistatin-like proteins such as FSL-3. Of three follistatin isoforms, the full-length mature follistatin (FST315) is the most abundant and the sole form in plasma, but has lower binding affinity for both activins and heparins than alternative forms. The acidic tail is missing in the splice variant FST288, which shows highest affinity, and partial in the proteolytically produced FST303, which shows intermediate affinity. Genetic deletion of follistatin in mice, or expression of only the FST288 form, is lethal perinatally due to defects of lung, skin and musculoskeletal system. Expression of only the FST315 isoform allows survival, with defects in vascularization and female fertility.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Follistatin (DFN00)(31)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Rat.


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Human
(23)
Mouse
(6)
Rat
(1)
Transgenic Rat
(1)
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Showing Publications 1 - 10 of 31. Show All 31 Publications.
Publications using DFN00 Applications Species
CA Perry, GP Van Guilde, TA Butterick Decreased myostatin in response to a controlled DASH diet is associated with improved body composition and cardiometabolic biomarkers in older adults: results from a controlled-feeding diet intervention study BMC nutrition, 2022;8(1):24. 2022 [PMID: 35287731] (Human) Human
M Amasene, C Cadenas-Sa, I Echeverria, B Sanz, C Alonso, I Tobalina, J Irazusta, I Labayen, A Besga Effects of Resistance Training Intervention along with Leucine-Enriched Whey Protein Supplementation on Sarcopenia and Frailty in Post-Hospitalized Older Adults: Preliminary Findings of a Randomized Controlled Trial Journal of Clinical Medicine, 2021;11(1):. 2021 [PMID: 35011838] (Human) Human
S Nawrocka-M, J Biegus, M Hurkacz, M Guzik, M Rosiek-Bie, EA Jankowska, P Ponikowski, R Zymli?ski Differences in the Biomarker Profile of De Novo Acute Heart Failure versus Decompensation of Chronic Heart Failure Biomolecules, 2021;11(11):. 2021 [PMID: 34827701] (Human) Human
C Wu, Y Borné, R Gao, M López Rodr, WC Roell, JM Wilson, A Regmi, C Luan, DM Aly, A Peter, J Machann, H Staiger, A Fritsche, AL Birkenfeld, R Tao, R Wagner, M Canouil, MG Hong, JM Schwenk, E Ahlqvist, MU Kaikkonen, P Nilsson, AC Shore, F Khan, A Natali, O Melander, M Orho-Melan, J Nilsson, HU Häring, E Renström, CB Wollheim, G Engström, J Weng, ER Pearson, PW Franks, MF White, KL Duffin, AA Vaag, M Laakso, N Stefan, L Groop, Y De Marinis Elevated circulating follistatin associates with an increased risk of type 2 diabetes Nature Communications, 2021;12(1):6486. 2021 [PMID: 34759311] (Human) Human
Y Du, C Xu, H Shi, X Jiang, W Tang, X Wu, M Chen, H Li, X Zhang, Q Cheng Serum concentrations of oxytocin, DHEA and follistatin are associated with osteoporosis or sarcopenia in community-dwelling postmenopausal women BMC geriatrics, 2021;21(1):542. 2021 [PMID: 34641817] (Human) Human
Z He, Y Tian, PL Valenzuela, C Huang, J Zhao, P Hong, Z He, S Yin, A Lucia Myokine/Adipokine Response to "Aerobic" Exercise: Is It Just a Matter of Exercise Load? Front Physiol, 2019;10(0):691. 2019 [PMID: 31191366] (Human) Human
S Sarcar, W Tulalamba, MY Rincon, J Tipanee, HQ Pham, H Evens, D Boon, E Samara-Kuk, M Keyaerts, M Loperfido, E Berardi, S Jarmin, P In't Veld, G Dickson, T Lahoutte, M Sampaolesi, P De Bleser, T VandenDrie, MK Chuah Next-generation muscle-directed gene therapy by in silico vector design Nat Commun, 2019;10(1):492. 2019 [PMID: 30700722] (Mouse) Mouse
Z He, Y Tian, PL Valenzuela, C Huang, J Zhao, P Hong, Z He, S Yin, A Lucia Myokine Response to High-Intensity Interval vs. Resistance Exercise: An Individual Approach Front Physiol, 2018;9(0):1735. 2018 [PMID: 30559681] (Human) Human
E Fife, J Kostka, ? Kroc, A Guligowska, M Pig?owska, B So?tysik, A Kaufman-Sz, K Fabianowsk, T Kostka Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men BMC Geriatr, 2018;18(1):200. 2018 [PMID: 30165829] (Human) Human
R Tao, C Wang, O Stöhr, W Qiu, Y Hu, J Miao, XC Dong, S Leng, M Stefater, N Stylopoulo, L Lin, KD Copps, MF White Inactivating hepatic follistatin alleviates hyperglycemia Nat. Med., 2018;0(0):. 2018 [PMID: 29867232] (Mouse) Mouse
Show All 31 Publications.

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Bioinformatics

Gene Symbol FST