Human Follistatin DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Follistatin DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: FST

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Follistatin DuoSet ELISA, 15 Plate

• follistatin isoform FST317
• Follistatin
• FS
• FSActivin-binding protein
• FST

Background

Follistatin (FST) is a secreted glycoprotein that binds and neutralizes several TGF-beta superfamily proteins including Activin, BMP-6, BMP-7, and GDF-8/Myostatin. It also binds Angiogenin and regulates hematopoietic stem cell adhesion to Fibronectin. Some Follistatin binding partners will also bind Follistatin-like proteins such as FSL-3. Of three follistatin isoforms, the full-length mature follistatin (FST315) is the most abundant and the sole form in plasma, but has lower binding affinity for both activins and heparins than alternative forms. The acidic tail is missing in the splice variant FST288, which shows highest affinity, and partial in the proteolytically produced FST303, which shows intermediate affinity. Genetic deletion of follistatin in mice, or expression of only the FST288 form, is lethal perinatally due to defects of lung, skin and musculoskeletal system. Expression of only the FST315 isoform allows survival, with defects in vascularization and female fertility.

Publications for Follistatin (DY669)(5)

Publications using DY669

• Nagayama, I;Takayanagi, K;Nagata, D;Hasegawa, H;Maeshima, A; Potential Utility of Urinary Follistatin as a Non-Invasive Indicator of Acute Tubular Damage in Patients with Acute Kidney Injury Cells 2024-03-16 [PMID: 38534369] (Human)
• Tarabeih, N;Kalinkovich, A;Shalata, A;Higla, O;Livshits, G; Pro-Inflammatory Biomarkers Combined with Body Composition Display a Strong Association with Knee Osteoarthritis in a Community-Based Study Biomolecules 2023-08-28 [PMID: 37759715] (Human)
• C Veraar, J Kliman, A Benazzo, F Oberndorfe, M Laggner, P Hacker, T Raunegger, S Janik, P Jaksch, W Klepetko, HJ Ankersmit, B Moser Potential novel biomarkers for chronic lung allograft dysfunction and azithromycin responsive allograft dysfunction Scientific Reports, 2021-03-24;11(1):6799. 2021-03-24 [PMID: 33762606] (Human)
• S Janik, C Bekos, P Hacker, T Raunegger, AI Schiefer, L Müllauer, C Veraar, B Dome, W Klepetko, HJ Ankersmit, B Moser Follistatin impacts Tumor Angiogenesis and Outcome in Thymic Epithelial Tumors Sci Rep, 2019-11-22;9(1):17359. 2019-11-22 [PMID: 31757999] (Human)
• N Tarabeih, A Shalata, S Trofimov, A Kalinkovic, G Livshits Growth and differentiation factor 15 is a biomarker for low back pain-associated disability Cytokine, 2019-02-15;117(0):8-14. 2019-02-15 [PMID: 30776685] (Human)

FAQs for Follistatin (DY669). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: FST