Human Endoglin/CD105 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Human Endoglin/CD105 Quantikine ELISA Kit Summary

Background
The Quantikine Human Endoglin Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human Endoglin in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human Endoglin and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Endoglin showed linear curves that were parallel to the standard curves obtained... using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring Endoglin.
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Specificity
Natural and recombinant human Endoglin
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
ENG

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using
DNDG00 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Endoglin/CD105 Quantikine ELISA Kit

  • CD105 antigen
  • CD105
  • Endoglin
  • ENDOsler-Rendu-Weber syndrome 1
  • ENG
  • HHT1FLJ41744
  • ORW
  • ORW1

Background

Endoglin (CD105) is a transmembrane type III receptor for TGF-beta superfamily ligands and plays an important role in smooth muscle differentiation, angiogenesis, and neovascularization. It is highly expressed on proliferating vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. Human Endoglin haploinsufficiency can a cause the vascular disorder, hereditary hemorrhagic telangiectasia type I. Elevated levels of anti-angiogenic soluble Endoglin contribute to pathogenicity in preeclampsia. Endoglin associates with the receptors TGF-beta RII, Activin RIIA or RIIB, BMPR-IA/ALK-3, or BMPR-IB/ALK6 and enhance binding of Activin A, BMP-2, -7, -9, TGF-beta 1, or TGF-beta 3. Endoglin can either enhance or inhibit signaling through these receptor complexes.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Endoglin/CD105 (DNDG00)(36)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Western Blot.


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Western Blot
(1)
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Human
(34)
Mouse
(2)
All Species
Showing Publications 1 - 10 of 36. Show All 36 Publications.
Publications using DNDG00 Applications Species
A Abascal-Sa, M Duque-Alco, V Fioravantt, E Antolín, E Fuente-Lue, M Haro, MP Ramos-Álva, G Perdomo, JL Bartha The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia Nutrients, 2022;14(10):. 2022 [PMID: 35631313] (Human) Human
EO Anto, DA Coall, EA Asiamah, OO Afriyie, O Addai-Mens, YA Wiafe, W Owiredu, C Obirikoran, ME Annani-Ako, NA Titiloye, E Adua, E Acheampong, EA Adu, S Opoku, AO Anto, A Tawiah, Y Wang, W Wang Placental lesions and differential expression of pro-and anti-angiogenic growth mediators and oxidative DNA damage marker in placentae of Ghanaian suboptimal and optimal health status pregnant women who later developed preeclampsia PLoS ONE, 2022;17(3):e0265717. 2022 [PMID: 35312727] (Human) Human
I Nejmanová, B Vitverová, S Eissazadeh, K Tripská, IC Igreja Sa, R Hyšpler, I N?me?kova, M Pericacho, P Nachtigal High Soluble Endoglin Levels Affect Aortic Vascular Function during Mice Aging Journal of cardiovascular development and disease, 2021;8(12):. 2021 [PMID: 34940528] (Human) Human
L Ruiz-Llore, MC Vega, FJ Fernández, C Langa, NW Morrell, PD Upton, C Bernabeu Generation of a Soluble Form of Human Endoglin Fused to Green Fluorescent Protein International Journal of Molecular Sciences, 2021;22(20):. 2021 [PMID: 34681942] (Human) Human
L Pérez-Roqu, E Núñez-Góme, A Rodríguez-, C Bernabéu, JM López-Novo, M Pericacho Pregnancy-Induced High Plasma Levels of Soluble Endoglin in Mice Lead to Preeclampsia Symptoms and Placental Abnormalities International Journal of Molecular Sciences, 2020;22(1):. 2020 [PMID: 33375253] (Human) Human
S Kim, M Park, JY Kim, T Kim, JY Hwang, KS Ha, MH Won, S Ryoo, YG Kwon, YM Kim Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia Cells, 2020;9(9):. 2020 [PMID: 32878300] (Human) Human
SP Polster, A Sharma, C Tanes, AT Tang, P Mericko, Y Cao, J Carrión-Pe, R Girard, J Koskimäki, D Zhang, A Stadnik, SG Romanos, SB Lyne, R Shenkar, K Yan, C Lee, A Akers, L Morrison, M Robinson, A Zafar, K Bittinger, H Kim, JA Gilbert, ML Kahn, L Shen, IA Awad Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma Nat Commun, 2020;11(1):2659. 2020 [PMID: 32461638] (Human) Human
DL Wilson, ME Howard, AM Fung, FJ O'Donoghue, M Barnes, M Lappas, SP Walker Sleep-disordered breathing does not impact maternal outcomes in women with hypertensive disorders of pregnancy PLoS ONE, 2020;15(4):e0232287. 2020 [PMID: 32339208] (Human) Human
E Gallardo-V, L Gamella-Po, L Perez-Roqu, JL Bartha, I Garcia-Pal, JI Casal, JM López-Novo, M Pericacho, C Bernabeu Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4 Cells, 2020;9(4):. 2020 [PMID: 32316263] (Human) Human
RA Rahman, P Murthi, H Singh, S Gurungsing, B Leaw, JC Mockler, R Lim, EM Wallace Hydroxychloroquine Mitigates the Production of 8-Isoprostane and Improves Vascular Dysfunction: Implications for Treating Preeclampsia Int J Mol Sci, 2020;21(7):. 2020 [PMID: 32260307] (Human) Human
Show All 36 Publications.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Endoglin/CD105 (DNDG00). (Showing 1 - 2 of 2 FAQs).

  1. I wonder if you have a CD105 or CD34 antibody suitable for IHC that is specific for human and do not bind mouse?
    • We do not have any anti-human CD34 or CD105 antibodies that are confirmed to NOT detect the mouse protein. When we have tested an antibody and confirmed that it will not react with mouse samples, we will add Mu(-) to the datasheet, and unfortunately all of our CD105 and CD34 antibodies will either detect the mouse protein, or they have not been used in mouse samples before.
  2. We are interested in CD105 antibodies that could react with dog, please let me know which products in your catalog you would recommend.
    • We do not currently carry any CD105 antibodies that have been validated for use in dog samples. However, if you are interested in testing any of our CD105 antibodies with dog samples you would be eligible for our Innovators Reward Program, in which you can get a discount voucher for the purchase price of the product. Please contact us at innovators@novusbio.com with any questions regarding this program.

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Gene Symbol ENG