Human ACE-2 DuoSet ELISA, 5 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human ACE-2 DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human ACE-2 DuoSet ELISA, 5 Plate

• ACE2
• ACE-2
• ACEH
• ACEHangiotensin I converting enzyme 2
• ACE-related carboxypeptidase
• angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
• angiotensin-converting enzyme 2
• Angiotensin-converting enzyme homolog
• DKFZp434A014
• EC 3.4.17
• EC 3.4.17.23
• Metalloprotease MPROT15

Background

Angiotensin converting enzyme 2 (ACE-2), also known as ACEH (ACE homolog), is an integral membrane protein and a zinc metalloprotease of the ACE family. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. ACE-2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2 . Amongst ongoing research into the cellular entry mechanism of coronavirus via ACE-2, an anti-human ACE-2 antibody (R&D Systems Catalog # AF933) has blocked this interaction.

Publications for ACE-2 (DY933-05)(14)

Publications using DY933-05

• da Silva-Santos, Y;Pagni, RL;Gamon, THM;de Azevedo, MSP;Darido, MLG;de Oliveira, DBL;Durigon, EL;Luvizotto, MCR;Ackerman, HC;Marinho, CRF;Carvalho, LJM;Epiphanio, S; Angiotensin-Converting Enzyme Inhibition and/or Angiotensin Receptor Blockade Modulate Cytokine Profiles and Improve Clinical Outcomes in Experimental COVID-19 Infection International journal of molecular sciences 2025-08-08 [PMID: 40868984] (Mouse)
• Kummarapurugu, AB;Hawkridge, AM;Ma, J;Osei, S;Martin, RK;Zheng, S;Voynow, JA; Neutrophil Elastase decreases SARS-CoV-2 Spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomian from the epithelial surface The Journal of biological chemistry 2023-05-13 [PMID: 37187291] (Human)
• J Dahmen, A Vermeulen, S Payne, C Lippmeier Thraustochytrid hosts for expression of proteins relevant to SARS-CoV-2 intervention PLoS ONE, 2023;18(4):e0283592. 2023 [PMID: 37043472] (Human)
• J Dahmen, A Vermeulen, S Payne, C Lippmeier Thraustochytrid hosts for expression of proteins relevant to SARS-CoV-2 intervention PLoS ONE, 2023-04-12;18(4):e0283592. 2023-04-12 [PMID: 37043472] (Human)
• S Huang, CG Taylor, P Zahradka Long Chain N3-PUFA Decreases ACE2 Protein Levels and Prevents SARS-CoV-2 Cell Entry International Journal of Molecular Sciences, 2022-11-10;23(22):. 2022-11-10 [PMID: 36430303] (Human)
• JV Harte, SL Wakerlin, AJ Lindsay, JV McCarthy, C Coleman-Va Metalloprotease-Dependent S2'-Activation Promotes Cell-Cell Fusion and Syncytiation of SARS-CoV-2 Viruses, 2022-09-21;14(10):. 2022-09-21 [PMID: 36298651] (Human)
• M Haffke, H Freitag, G Rudolf, M Seifert, W Doehner, N Scherbakov, L Hanitsch, K Wittke, S Bauer, F Konietschk, F Paul, J Bellmann-S, C Kedor, C Scheibenbo, F Sotzny Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS) Journal of Translational Medicine, 2022-03-22;20(1):138. 2022-03-22 [PMID: 35317812] (Human)
• V Montiel, I Lobysheva, L Gérard, M Vermeersch, D Perez-Morg, T Castelein, JB Mesland, P Hantson, C Collienne, D Gruson, MA van Dievoe, A Persu, C Beauloye, M Dechamps, L Belkhir, A Robert, M Derive, PF Laterre, AHJ Danser, X Wittebole, JL Balligand Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients EBioMedicine, 2022-02-23;77(0):103893. 2022-02-23 [PMID: 35219085] (Human)
• Elizabeth S. Taglauer, Elisha M. Wachman, Lillian Juttukonda, Timothy Klouda, Jiwon Kim, Qiong Wang et al. Acute Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy Is Associated with Placental Angiotensin-Converting Enzyme 2 Shedding The American Journal of Pathology 2023-04-01 [PMID: 35090860] (Human)
• R Reddy, I Efimenko, W Chertman, T Kohn, P Diaz, D Seetharam, K Khodamorad, E Kresch, R Ramasamy Whole Exome Sequencing Identifies a Rare Mutation in NACAD as a Possible Cause of COVID Orchitis in Brothers Urology, 2021-10-20;0(0):. 2021-10-20 [PMID: 34678309] (Human)
• April Rees, Steve Turner, Catherine A. Thornton Potential protective effects of breast milk and amniotic fluid against novel coronavirus SARS‐CoV‐2 through decoy receptors Pediatric Allergy and Immunology 2022-01-01 [PMID: 34585801] (Human)
• G Wirnsberge, V Monteil, B Eaton, E Postnikova, M Murphy, B Braunsfeld, I Crozier, F Kricek, J Niederhöfe, A Schwarzböc, H Breid, A Sanchez Ji, A Bugajska-S, A Dohnal, C Ruf, R Gugenberge, A Hagelkruys, N Montserrat, MR Holbrook, C Oostenbrin, RH Shoemaker, A Mirazimi, JM Penninger Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants bioRxiv : the preprint server for biology, 2021-09-10;0(0):. 2021-09-10 [PMID: 34545368] (ELISA Capture, Human)
• NM Elemam, H Hasswan, H Aljaibeji, N Sulaiman Circulating Soluble ACE2 and Upstream microRNA Expressions in Serum of Type 2 Diabetes Mellitus Patients International Journal of Molecular Sciences, 2021-05-17;22(10):. 2021-05-17 [PMID: 34067683] (Human)
• A Sturrock, E Zimmerman, M Helms, TG Liou, R Paine Hypoxia induces expression of angiotensin-converting enzyme II in alveolar epithelial cells: Implications for the pathogenesis of acute lung injury in COVID-19 Physiological Reports, 2021-05-01;9(9):e14854. 2021-05-01 [PMID: 33991451] (Human)

FAQs for ACE-2 (DY933-05). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.