Glypican 3 Antibody (1G12 + GPC3/863) [DyLight 650]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, IHC-P, ICC/IF
Clone
1G12 + GPC3/863
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 650

Glypican 3 Antibody (1G12 + GPC3/863) [DyLight 650] Summary

Immunogen
Recombinant fragment containing amino acids 511-580 of human glypican-3 (1G12); Recombinant full-length human GPC3 protein (GPC3/863)
Localization
Cytoplasmic
Marker
Hepatocellular Carcinoma Marker
Specificity
Glypican-3 (GPC3) is an integral membrane protein that is mutated in the Simpson-Golabi-Behmel syndrome (SGBS). SGBS is characterized by pre- and post-natal overgrowth and is a recessive X-linked condition. GPC3 may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression has also been found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma was significantly higher than that of follicular adenoma. In contrast, GPC 3 is not expressed in anaplastic carcinoma.
Isotype
IgG
Clonality
Monoclonal
Host
Mouse
Gene
GPC3
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Glypican 3 Antibody (1G12 + GPC3/863) [DyLight 650]

  • DGSX
  • Glypican 3
  • glypican proteoglycan 3
  • glypican-3
  • GPC3
  • GTR2-2
  • heparan sulphate proteoglycan
  • Intestinal protein OCI-5
  • MXR7
  • OCI5
  • OCI-5
  • secreted glypican-3
  • SGB
  • SGBS
  • SGBS1SDYS

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 NBP2-47763AF405
Alexa Fluor 488 NBP2-47763AF488
Alexa Fluor 647 NBP2-47763AF647
Alexa Fluor 700 NBP2-47763AF700
Allophycocyanin NBP2-47763APC
Biotin NBP2-47763B
DyLight 350 NBP2-47763UV
DyLight 405 NBP2-47763V
DyLight 488 NBP2-47763G
DyLight 550 NBP2-47763R
DyLight 650 NBP2-47763C
DyLight 680 NBP2-47763FR
DyLight 755 NBP2-47763IR
FITC NBP2-47763F
HRP NBP2-47763H
Janelia Fluor 549 NBP2-47763JF549
Janelia Fluor 646 NBP2-47763JF646
PE NBP2-47763PE
PerCP NBP2-47763PCP

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Bioinformatics Tool for Glypican 3 Antibody (NBP2-47763C)

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Bioinformatics

Gene Symbol GPC3