ERR gamma/NR3B3 Antibody

Images

 
Immunohistochemistry-Paraffin: ERR gamma/NR3B3 Antibody [NLS5960] - Anti-ESRRG / ERR Gamma antibody IHC of human kidney, diabetes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced ...read more
Immunohistochemistry: ERR gamma/NR3B3 Antibody [NLS5960] - IHC analysis of Breast cancer using this antibody at 9 ug/ ml.
Immunohistochemistry-Paraffin: ERR gamma/NR3B3 Antibody [NLS5960] - IHC staining of human breast cancer.
Immunohistochemistry-Paraffin: ERR gamma/NR3B3 Antibody [NLS5960] - Analysis of anti-ESRRG / ERR Gamma antibody with human brain, glioblastoma.
Immunohistochemistry-Paraffin: ERR gamma/NR3B3 Antibody [NLS5960] - Anti-ESRRG / ERR Gamma antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen ...read more
Immunohistochemistry-Paraffin: ERR gamma/NR3B3 Antibody [NLS5960] - Anti-ESRRG / ERR Gamma antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced ...read more
Immunohistochemistry-Paraffin: ERR gamma/NR3B3 Antibody [NLS5960] - Anti-ESRRG / ERR Gamma antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Ca, Ch, Eq, Ha, Mk, Pm, Rb, Bt, Op, Tr, Xp, ZeSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

ERR gamma/NR3B3 Antibody Summary

Immunogen
Synthetic 15 amino acid peptide from C-terminus of human ESRRG / ERR3.
Localization
Nuclear
Specificity
Human ESRRG / ERR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Zebrafish (93%), Opossum (100%), Xenopus (93%), Turkey (100%), Bat (93%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ESRRG
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 9 - 17 ug/ml

Reactivity Notes

Gorilla, Orangutan, Gibobn, Marmoset. Predicted cross-reactivity based on sequence identity: Elephant (100%), Panda (100%), Platypus (100%), Lizard (100%), Stickleback (87%), Medaka (87%), Pufferfish (87%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ERR gamma/NR3B3 Antibody

  • DKFZp781L1617
  • ERR gamma
  • ERR gamma-2
  • ERR3
  • ERRG2
  • ERRgamma
  • ESRRG
  • Estrogen receptor-related protein 3
  • estrogen-related receptor gamma
  • FLJ16023
  • KIAA0832
  • NR3B3
  • Nuclear receptor subfamily 3 group B member 3

Background

Estrogen receptor-related receptor (ERR gamma), a NR3 Steroid Receptor, has been suggested to affect differentiation of the brain, heart, and kidney. ERR gamma binds as a monomer to an extended half-site of the ERRE type (TCAAGGTCA). ERR gamma has been shown to interact with PGC-1 alpha and has been implicated in the regulation of mitochondrial energy metabolism. In humans, ERR gamma pre-mRNA undergoes extensive alternative splicing at the 5 end, yielding at least six mRNA splice variants and two protein isoforms that differ by 23 amino acids in the N terminus. ERR gamma has been shown to be overexpressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course. As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development. ERR gamma expression at the mRNA and protein levels is isoform- and tissue-specific in humans. ERR gamma expression has been documented in human heart, brain, placenta, skeletal muscle, kidney, pancreas, spleen, prostate, testis, and small intestine. ESTs have been isolated from human tissue libraries, including cancerous fetus, uterus, lung, breast, head/neck, colon, skin, eye, adrenal, and breast, and normal placenta, kidney, brain, eye, pineal, ear, and heart.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: IHC, IHC-P

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ESRRG
Entrez
Uniprot