ERR beta/NR3B2 Antibody (H6705)

• Reactivity: Hu
• Applications: WB, IHC, IP
• Clone: H6705
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Suitable Sample Type: 23015

ERR beta/NR3B2 Antibody (H6705) Summary

• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: ESRRB

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 5-15 ug/mL
  • Immunoprecipitation
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
• Buffer: A liquid formulation in physiologic saline with 0.1% NaN₃.
• Preservative: 0.1% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ERR beta/NR3B2 Antibody (H6705)

• ERR beta
• ERR2
• ESRL2
• ESRRB
• estrogen-related receptor beta
• NR3B2

Background

Estrogen-related receptor alpha (ERR-alpha, ERR1, ESRL1; NR3B1) is a member of the orphan nuclear receptor family. ERR-alpha is expressed in the liver, kidney, brain, heart, uterus, vagina and cervix. ERR-alpha takes part in the cell cycle and the fatty acid metabolizing of the musculus skeleti. ERR-alpha was shown to interact with ER-alpha. ERR-beta (ERR2; NR3B2) is also expressed in the liver, brain, uterus, vagina, and cervix. ERR-beta has a role in early placental development. ERR-gamma (ESRRG; NR3B3) is expressed in the brain, kidney, testis, lung, adrenal gland, pancreas, placenta and bone marrow. ERR-gamma was shown to be located in the critical region for Usher's syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ERR beta/NR3B2 Antibody (PP-H6705-00)(9)

Publications using PP-H6705-00

• MN Khan, P Cherukuri, F Negro, A Rajput, P Fabrowski, V Bansal, C Lancelin, TI Lee, Y Bian, WP Mayer, T Akay, D Müller, S Bonn, D Farina, T Marquardt ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control PloS Biology, 2022;20(12):e3001923. 2022 [PMID: 36542664] (IHC, Human)
• J Bayerl, M Ayyash, T Shani, YS Manor, O Gafni, R Massarwa, Y Kalma, A Aguilera-C, M Zerbib, H Amir, D Sheban, S Geula, N Mor, L Weinberger, S Naveh Tass, V Krupalnik, B Oldak, N Livnat, S Tarazi, S Tawil, E Wildschutz, S Ashouokhi, L Lasman, V Rotter, S Hanna, D Ben-Yosef, N Novershter, S Viukov, JH Hanna Principles of signaling pathway modulation for enhancing human naive pluripotency induction Cell Stem Cell, 2021;0(0):. 2021 [PMID: 33915080] (ICC, Mouse)
• R Fan, YS Kim, J Wu, R Chen, D Zeuschner, K Mildner, K Adachi, G Wu, S Galatidou, J Li, HR Schöler, SA Leidel, I Bedzhov Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause Nat Commun, 2020;11(1):5499. 2020 [PMID: 33127892] (ICC, Mouse)
• A Bahat, A Goldman, Y Zaltsman, DH Khan, C Halperin, E Amzallag, V Krupalnik, M Mullokando, A Silberman, A Erez, AD Schimmer, JH Hanna, A Gross MTCH2-mediated mitochondrial fusion drives exit from na�ve pluripotency in embryonic stem cells Nat Commun, 2018;9(1):5132. 2018 [PMID: 30510213] (ICC, Human)
• JL Sardina, S Collombet, TV Tian, A Gómez, B Di Stefano, C Berenguer, J Brumbaugh, R Stadhouder, C Segura-Mor, M Gut, IG Gut, S Heath, S Aranda, L Di Croce, K Hochedling, D Thieffry, T Graf Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate Cell Stem Cell, 2018;0(0):. 2018 [PMID: 30220521] (Immunoprecipitation, Mouse)
• Daniel A Rappolee Departure from optimal O2 level for mouse trophoblast stem cell proliferation and potency leads to most rapid AMPK activation J. Reprod. Dev., 2016;0(0):. 2016 [PMID: 27867161] (Western Blot, Mouse)
• Kumar , Roshan M, Cahan , Patrick, Shalek , Alex K, Satija , Rahul, DaleyKeyser , A Jay, Li , Hu, Zhang , Jin, Pardee , Keith, Gennert , David, Trombetta , John J, Ferrante , Thomas C, Regev , Aviv, Daley , George Q, Collins , James J Deconstructing transcriptional heterogeneity in pluripotent stem cells. Nature, 2014;516(7529):56-61. 2014 [PMID: 25471879] (IHC, Mouse)
• Percharde M, Lavial F, Ng J, Kumar V, Tomaz R, Martin N, Yeo J, Gil J, Prabhakar S, Ng H, Parker M, Azuara V Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev, 2012;26(20):2286-98. 2012 [PMID: 23019124] (ICC, Mouse)
• van den Berg DL, Zhang W, Yates A, Engelen E, Takacs K, Bezstarosti K, Demmers J, Chambers I, Poot RA Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. Mol. Cell. Biol., 2008;28(19):5986-95. 2008 [PMID: 18662995] (ICC, Human)

Bioinformatics

• Gene Symbol: ESRRB