ERR gamma/NR3B3 Antibody

Images

 
Western Blot: ERR gamma/NR3B3 Antibody [NBP1-32853] - Rat spleen lysate/extract.
Western Blot: ERR gamma/NR3B3 Antibody [NBP1-32853] - Sample (30 ug of whole cell lysate) A: A431 10% SDS PAGE, antibody diluted at 1:3000.
Western Blot: ERR gamma/NR3B3 Antibody [NBP1-32853] - Sample (50 ug of whole cell lysate) A: Mouse brain 10% SDS PAGE; antibody diluted at 1:1000.

Product Details

Summary
Reactivity Hu, Mu, Rt, ChSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.51 mg/ml

Order Details

ERR gamma/NR3B3 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human ERR gamma. The exact sequence is proprietary.
Localization
Nucleus
Predicted Species
Chicken (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ESRRG
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
Theoretical MW
51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.51 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ERR gamma/NR3B3 Antibody

  • DKFZp781L1617
  • ERR gamma
  • ERR gamma-2
  • ERR3
  • ERRG2
  • ERRgamma
  • ESRRG
  • Estrogen receptor-related protein 3
  • estrogen-related receptor gamma
  • FLJ16023
  • KIAA0832
  • NR3B3
  • Nuclear receptor subfamily 3 group B member 3

Background

Estrogen related receptor (ERR gamma), a NR3 Steroid Receptor is an orphan member of the nuclear hormone receptor superfamily. All the ERR family members (1,2, and 3) share an almost identical DNA binding domain, which has 68% amino acid identity with that of estrogen receptor. Studies involving the crystal structure of the LBD have shown a complex between ERR3 and SRC1. ERR gamma has been suggested to affect differentiation of the brain, heart, and kidney. ERR gamma binds as a monomer to an extended half site of the ERRE type (TCAAGGTCA). ERR gamma has been shown to interact with PGC1 alpha and has been implicated in the regulation of mitochondrial energy metabolism. In humans, ERR gamma pre mRNA undergoes extensive alternative splicing at the 5 prime end, yielding at least six mRNA splice variants and two protein isoforms that differ by 23 amino acids in the N terminus. ERR gamma has been shown to be over expressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course. As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for ERR gamma/NR3B3 Antibody (NBP1-32853). (Showing 1 - 1 of 1 FAQ).

  1. I am looking for an antibody to detect human ERRgamma by Western blot in primary human muscle cells. There are several antibodies indicating for WB from Novus. Could you recommend the best one for me to order. thanks!
    • NBP1-32853 works well for Western blot in human tissue. The positive control I would recommend is Hela, A431, HepG2 or Raji cells.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol ESRRG
Entrez