ERR beta/NR3B2 Antibody - BSA Free

Immunohistochemistry-Paraffin: ERR beta/NR3B2 Antibody [NBP3-14318] - Immunohistochemistry of formalin-fixed, paraffin-embedded human uterus, endometrial glands, after heat-induced antigen retrieval.

• Reactivity: Hu, Mu, Rt, Eq, Pm, Pm
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

ERR beta/NR3B2 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 16 amino acid peptide from N-Terminus of human ERR beta/NR3B2.
• Epitope: N-Terminus
• Specificity: Human ERR beta/NR3B2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Mouse (94%), Rat (94%), Equine (100%), Primate (100%), Monkey (100%). Backed by our 100% Guarantee.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ESRRB
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: .

Reactivity Notes

Expected reactivity based on percent sequence identity: Canine, Porcine (88%), Bat, Bovine, Rabbit (81%)

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ERR beta/NR3B2 Antibody - BSA Free

• ERR beta
• ERR2
• ESRL2
• ESRRB
• estrogen-related receptor beta
• NR3B2

Background

Estrogen-related receptor beta (ERR beta) a NR3 Steroid Receptor, has been shown to affect early placental development. ERR beta also can act as a repressor of transcriptional activity mediated by the glucocorticoid receptor (GR). ERR beta binds as a monomer to the extended half-site TNAAGTGCA and as a homodimer to the estrogen response element (ERE), palindromic thyroid hormone response element (TRE(pal)), and SF-1 response element, but not to the glucocorticoid response element (GRE). ERR beta mutations lead to abnormal development of the chorion and defective diploid trophoblast proliferation, and are lethal during midgestation. ERR beta expression has been documented in mice in the extraembryonic ectoderm that gives rise to the chorion. ESTs have been isolated from normal human eye, lung, and testis libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ESRRB