CYP7A1 Antibody (946902) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 946902
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

CYP7A1 Antibody (946902) [Alexa Fluor® 750] Summary

• Immunogen: Human CYP7A1 synthetic peptide
  Accession # P22680
• Specificity: Detects human CYP7A1 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CYP7A1 Antibody (946902) [Alexa Fluor® 750]

• Cholesterol 7-alpha-hydroxylase
• cholesterol 7-alpha-monooxygenase
• CP7A
• CYP7
• CYP7A1
• CYP7MGC126826
• CYPVII
• Cytochrome P450 7A1
• cytochrome P450, family 7, subfamily A, polypeptide 1
• cytochrome P450, subfamily VIIA (cholesterol 7 alpha-monooxygenase)
• cytochrome P450, subfamily VIIA polypeptide 1
• EC 1.14.13
• EC 1.14.13.17
• MGC138389
• polypeptide 1

Background

CYP7A1 (cytochrome P450 7A1; also Cholesterol 7-alph-monooxygenase) is a 504 aa oxidoreductase enzyme (SwissProt #: P22680).  Human CYP7A1 shares 81% and 82% aa identity with mouse and rat CYP7A1, respectively.  It is expressed in the liver where it catalyzes cholesterol metabolism, which is the rate-limiting step in bile acid synthesis.  Disruption of CYP7A1 is associated with high plasma cholesterol levels leading to increased risk of coronary artery disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.