CXCR3 Antibody (220803) [Allophycocyanin]

Mouse splenocytes were stained with Rat Anti-Mouse CD3 PE-conjugated Monoclonal Antibody (Catalog # FAB4841P) and either (A) Rat Anti-Mouse CXCR3 APC-conjugated Monoclonal Antibody (Catalog # FAB1685A) or (B) Rat IgG2AAllophycocyanin Isotype Control (Catalog # IC006A). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Mu
• Applications: Flow
• Clone: 220803
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Allophycocyanin

CXCR3 Antibody (220803) [Allophycocyanin] Summary

• Immunogen: CHO Chinese hamster ovary cell line transfected with mouse CXCR3
  Met1-Leu367
  Accession # AAC40163
• Specificity: Detects mouse CXCR3.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: CXCR3
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCR3 Antibody (220803) [Allophycocyanin]

• CD183 antigen
• CD183
• chemokine (C-X-C motif) receptor 3
• chemokine (C-X-C) receptor 3
• CKR-L2IP-10 receptor
• CMKAR3
• C-X-C chemokine receptor type 3
• CXCR3
• CXC-R3
• CXCR-3
• G protein-coupled receptor 9CD182
• GPR9
• GPR9Mig-R
• Interferon-inducible protein 10 receptor
• IP10 receptor
• IP10-R
• Mig receptor
• MigR

Background

CXCR3 is a G protein coupled chemokine receptor that binds the alpha chemokines MIG (CXCL9), IP-10 (CXCL10) and I-TAC (CXCL11). CXCR3 is expressed on activated T cells, B cells and NK cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CXCR3 Antibody (FAB1685A)(7)

Publications using FAB1685A

• M. E. Mikucki, D. T. Fisher, J. Matsuzaki, J. J. Skitzki, N. B. Gaulin, J. B. Muhitch et al. Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints Nature Communications 2015-06-25 [PMID: 26109379]
• Angkasekwinai P, Sringkarin N, Supasorn O, Fungkrajai M, Wang Y, Chayakulkeeree M, Ngamskulrungroj P, Angkasekwinai N, Pattanapanyasat K Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts. Infect Immun, 2014-06-30;82(9):3880-90. 2014-06-30 [PMID: 24980974] (Flow Cytometry, Mouse)
• Mackay L, Rahimpour A, Ma J, Collins N, Stock A, Hafon M, Vega-Ramos J, Lauzurica P, Mueller S, Stefanovic T, Tscharke D, Heath W, Inouye M, Carbone F, Gebhardt T The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. Nat Immunol, 2013-10-27;14(12):1294-301. 2013-10-27 [PMID: 24162776] (Flow Cytometry, Mouse)
• Lacotte S, Decossas M, Le Coz C, Brun S, Muller S, Dumortier H Early differentiated CD138(high) MHCII+ IgG+ plasma cells express CXCR3 and localize into inflamed kidneys of lupus mice. PLoS ONE, 2013-03-08;8(3):e58140. 2013-03-08 [PMID: 23520491] (Flow Cytometry, Mouse)
• Giegold O, Ogrissek N, Richter C, Schroder M, Herrero San Juan M, Pfeilschifter J, Radeke H CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation. J Immunol, 2013-02-27;190(7):3696-705. 2013-02-27 [PMID: 23447686] (Flow Cytometry, Mouse)
• Liu C, Luo D, Reynolds BA Chemokine receptor CXCR3 promotes growth of glioma. Carcinogenesis, 2010-11-03;32(2):129-37. 2010-11-03 [PMID: 21051441] (Flow Cytometry, Mouse)
• Miu J, Mitchell AJ, Muller M, Carter SL, Manders PM, McQuillan JA, Saunders BM, Ball HJ, Lu B, Campbell IL, Hunt NH Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. J. Immunol., 2008-01-15;180(2):1217-30. 2008-01-15 [PMID: 18178862] (Flow Cytometry, Mouse)

Reviews for CXCR3 Antibody (FAB1685A) (2)

Average Rating: 5

(Based on 2 reviews)

We have 2 reviews tested in 1 species: Mouse.

reviewed by: Verified Customer Flow Mouse 01/21/2015

Summary

• Application: Flow Cytometry
• Sample Tested: See PMID: 23447686
• Species: Mouse

reviewed by: Verified Customer Flow Mouse 01/21/2015

Summary

• Application: Flow Cytometry
• Sample Tested: See PMID: 23447686
• Species: Mouse

Bioinformatics

• Gene Symbol: CXCR3
• Uniprot:
  • AAC40163()