Mouse CCL17/TARC Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse CCL17/TARC Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse TARC Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse TARC levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse TARC and antibodies raised against the recombinant factor. Results obtained for naturally occurring mouse TARC showed linear curves that were parallel to the standard curves obtained... using the kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse TARC.
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• Specificity: Natural and recombinant mouse TARC
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Ccl17

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CCL17/TARC Quantikine ELISA Kit

• ABCD-2
• CC chemokine TARC
• C-C motif chemokine 17
• CCL17
• chemokine (C-C motif) ligand 17
• MGC138273
• SCYA17
• SCYA17MGC138271
• small inducible cytokine subfamily A (Cys-Cys), member 17
• Small-inducible cytokine A17
• T cell-directed CC chemokine
• TARC
• TARCA-152E5.3
• Thymus and activation-regulated chemokine

Background

CCL17/TARC is a chemokine that interacts with CCR4 and CCR8 to induce the chemoattraction of activated Th2 cells, basophils, and NK cells. It is produced by thymic dendritic cells, lymph node dendritic cells, monocytes, CD4+ T cells, keratinocytes, fibroblasts, bronchial epithelial cells, and Reed-Sternberg cells. CCL17 promotes Th2 cell recruitment to sites of inflammation and induces platelet aggregation and degranulation.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CCL17/TARC (MCC170)(45)

Publications using MCC170

• P Huang, F Hu, ZB Yang, Y Pan, R Zhou, YN Yan, HZ Wang, C Wang Matrine regulates Th1/Th2 inflammatory responses by inhibiting the Hsp90/NF-kappaB signaling axis to alleviate atopic dermatitis The Kaohsiung journal of medical sciences, 2023-02-09;0(0):. 2023-02-09 [PMID: 36757049] (Mouse)
• BW Lewis, ML Ford, AQ Khan, J Walum, RD Britt Chronic Allergen Challenge Induces Corticosteroid Insensitivity With Persistent Airway Remodeling and Type 2 Inflammation Frontiers in Pharmacology, 2022-04-11;13(0):855247. 2022-04-11 [PMID: 35479312] (Mouse)
• K Ming-Chin, AA Achuthan, DP De Souza, TJ Lupancu, KJ Binger, MKS Lee, Y Xu, MJ McConville, NA de Weerd, D Dragoljevi, PJ Hertzog, AJ Murphy, JA Hamilton, AJ Fleetwood Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization Cell Reports, 2022-04-19;39(3):110719. 2022-04-19 [PMID: 35443173] (Mouse)
• CM Park, HY Kim, D Jeon, YJ Shin, IH Kim, SJ Choi, KC Kim, K Lee, SH Kim, MS Kim Anti-fibrotic effect of Pycnogenol� in a polyhexamethylene guanidine-treated mouse model Respiratory physiology & neurobiology, 2021-10-12;0(0):103802. 2021-10-12 [PMID: 34653662] (Mouse)
• Y Song, X Li, F Liu, H Zhu, Y Shen Isoalantolactone alleviates ovalbumin?induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR?gamma/KLF4 signals Molecular Medicine Reports, 2021-08-09;24(4):. 2021-08-09 [PMID: 34368878] (Mouse)
• KJ Warren, JA Poole, JM Sweeter, JM DeVasure, JD Dickinson, RS Peebles, TA Wyatt Neutralization of IL-33 modifies the type 2 and type 3 inflammatory signature of viral induced asthma exacerbation Respiratory Research, 2021-07-15;22(1):206. 2021-07-15 [PMID: 34266437] (Mouse)
• K Tajiri, K Imanaka-Yo, Y Tsujimura, K Matsuo, M Hiroe, K Aonuma, M Ieda, Y Yasutomi A New Mouse Model of Chronic Myocarditis Induced by Recombinant Bacille Calmette-Gu�rin Expressing a T-Cell Epitope of Cardiac Myosin Heavy Chain-&alpha International Journal of Molecular Sciences, 2021-01-14;22(2):. 2021-01-14 [PMID: 33466825] (Mouse)
• JH Park, MH Hwang, YR Cho, SS Hong, JS Kang, WH Kim, SH Yang, DW Seo, JS Oh, EK Ahn Combretum quadrangulare Extract Attenuates Atopic Dermatitis-Like Skin Lesions through Modulation of MAPK Signaling in BALB/c Mice Molecules, 2020-04-24;25(8):. 2020-04-24 [PMID: 32344690] (Mouse)
• A Hirata, H Hashimoto, C Shibasaki, K Narumi, K Aoki Intratumoral IFN-? gene delivery reduces tumor-infiltrating regulatory T cells through the downregulation of tumor CCL17 expression Cancer Gene Ther., 2018-11-12;0(0):. 2018-11-12 [PMID: 30420718] (Mouse)
• S Yi, J Zhai, R Niu, G Zhu, M Wang, J Liu, H Huang, Y Wang, X Jing, L Kang, W Song, Y Shi, H Tang Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge Nat Commun, 2018-09-24;9(1):3879. 2018-09-24 [PMID: 30250029] (Mouse)
• IK Kim, K Kim, E Lee, DS Oh, CS Park, S Park, JM Yang, JH Kim, HS Kim, DT Shima, JH Kim, SH Hong, YH Cho, YH Kim, JB Park, GY Koh, YS Ju, HK Lee, S Lee, I Kim Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality J. Exp. Med., 2018-02-14;0(0):. 2018-02-14 [PMID: 29444818] (ELISA Capture, Mouse)
• I Nishioka, T Takai, N Maruyama, S Kamijo, P Suchiva, M Suzuki, S Kunimine, H Ochi, S Shimura, K Sudo, H Ogawa, K Okumura, S Ikeda Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation J. Allergy Clin. Immunol., 2018-02-06;0(0):. 2018-02-06 [PMID: 29426602] (Mouse)
• Kobayashi T, Glatz M, Horiuchi K, Kawasaki H, Akiyama H, Kaplan D, Kong H, Amagai M, Nagao K Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis. Immunity, 2015-04-21;42(4):756-66. 2015-04-21 [PMID: 25902485] (Mouse)
• Mishra , Amarjit, Brown , Alexandr, Yao , Xianglan, Yang , Shutong, Park , Sung-Jun, Liu , Chengyu, Dagur , Pradeep, McCoy , J Philip, Keeran , Karen J, Nugent , Gayle Z, Jeffries , Kenneth, Qu , Xuan, Yu , Zu-Xi, Levine , Stewart, Chung , Jay H Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase. Nat Commun, 2015-02-18;6(0):6224. 2015-02-18 [PMID: 25692509] (Mouse)
• Medina , Jorge L, Coalson , Jacqueli, Brooks , Edward G, Le Saux , Claude J, Winter , Vicki T, Chaparro , Adriana, Principe , Molly F, Solis , Laura, Kannan , T R, Baseman , Joel B, Dube , Peter H Mycoplasma pneumoniae CARDS toxin exacerbates ovalbumin-induced asthma-like inflammation in BALB/c mice. PLoS ONE, 2014-07-24;9(7):e102613. 2014-07-24 [PMID: 25058417] (Mouse)
• Brenndorfer E, Brass A, Karthe J, Ahlen G, Bode J, Sallberg M Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy. J Immunol, 2014-01-17;192(4):1671-80. 2014-01-17 [PMID: 24442435] (Mouse)
• Maina , Virginia, Marrella , Veronica, Mantero , Stefano, Cassani , Barbara, Fontana , Elena, Anselmo , Achille, Del Prete , Annalisa, Sozzani , Silvano, Vezzoni , Paolo, Poliani , Pietro L, Villa , Anna Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration. J Leukoc Biol, 2013-09-19;94(6):1221-30. 2013-09-19 [PMID: 24052573] (Mouse)
• Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung. J. Immunol., 2012-07-30;189(5):2545-52. 2012-07-30 [PMID: 22851704] (Mouse)
• Taube C, Tertilt C, Gyulveszi G, Dehzad N, Kreymborg K, Schneeweiss K, Michel E, Reuter S, Renauld JC, Arnold-Schild D, Schild H, Buhl R, Becher B IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease. PLoS ONE, 2011-07-18;6(7):e21799. 2011-07-18 [PMID: 21789181] (Mouse)
• Barlow JL, Flynn RJ, Ballantyne SJ, McKenzie AN Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity. Clin. Exp. Allergy, 2011-07-04;41(10):1447-55. 2011-07-04 [PMID: 21722219] (Mouse)
• Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. Am. J. Pathol., 2011-05-10;179(1):302-14. 2011-05-10 [PMID: 21703412] (Mouse)
• Kashyap M, Rochman Y, Spolski R Thymic stromal lymphopoietin is produced by dendritic cells. J. Immunol., 2011-06-20;187(3):1207-11. 2011-06-20 [PMID: 21690322] (Mouse)
• Olkhanud PB, Rochman Y, Bodogai M Thymic stromal lymphopoietin is a key mediator of breast cancer progression. J. Immunol., 2011-04-13;186(10):5656-62. 2011-04-13 [PMID: 21490155] (Mouse)
• Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur. J. Immunol., 2011-05-25;41(6):1675-86. 2011-05-25 [PMID: 21469105] (Mouse)
• Louten J, Rankin AL, Li Y Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation. Int. Immunol., 2011-03-21;23(5):307-15. 2011-03-21 [PMID: 21422152] (Mouse)
• Nelson MP, Christmann BS, Werner JL, Metz AE, Trevor JL, Lowell CA, Steele C IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. J. Immunol., 2011-01-10;186(4):2372-81. 2011-01-10 [PMID: 21220696] (Mouse)
• Chen G, Wan H, Luo F Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J. Immunol., 2010-05-05;184(11):6133-41. 2010-05-05 [PMID: 20483781] (Mouse)
• Hatano Y, Man MQ, Uchida Y, Crumrine D, Mauro TM, Feingold KR, Elias PM, Holleran WM Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators. J. Allergy Clin. Immunol., 2009-10-08;125(1):160-9.e1-5. 2009-10-08 [PMID: 19818482] (Mouse)
• Chiba Y, Sato S, Misawa M Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice. Inflamm. Res., 2009-05-06;0(0):. 2009-05-06 [PMID: 19418204] (Mouse)
• Thomay AA, Daley JM, Sabo E, Worth PJ, Shelton LJ, Harty MW, Reichner JS, Albina JE Disruption of interleukin-1 signaling improves the quality of wound healing. Am. J. Pathol., 2009-04-23;174(6):2129-36. 2009-04-23 [PMID: 19389930] (Mouse)
• Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis. J. Invest. Dermatol., 2009-01-29;129(7):1824-35. 2009-01-29 [PMID: 19177139] (Mouse)
• Medoff BD, Seung E, Hong S, Thomas SY, Sandall BP, Duffield JS, Kuperman DA, Erle DJ, Luster AD CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation. J. Immunol., 2009-01-01;182(1):623-35. 2009-01-01 [PMID: 19109196] (Mouse)
• Zhou W, Newcomb DC, Moore ML, Goleniewska K, O'Neal JF, Peebles RS Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses. J. Immunol., 2008-10-15;181(8):5360-7. 2008-10-15 [PMID: 18832692] (Mouse)
• Voskas D, Babichev Y, Ling LS, Alami J, Shaked Y, Kerbel RS, Ciruna B, Dumont DJ An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice. J. Leukoc. Biol., 2008-05-01;84(1):59-67. 2008-05-01 [PMID: 18443190] (Mouse)
• Trujillo G, O'Connor EC, Kunkel SL, Hogaboam CM A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis. Am. J. Pathol., 2008-04-10;172(5):1209-21. 2008-04-10 [PMID: 18403600] (Mouse)
• Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J. Exp. Med., 2008-03-03;205(3):699-710. 2008-03-03 [PMID: 18316417] (Mouse)
• Meyer EH, Wurbel MA, Staton TL, Pichavant M, Kan MJ, Savage PB, DeKruyff RH, Butcher EC, Campbell JJ, Umetsu DT iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. J. Immunol., 2007-10-01;179(7):4661-71. 2007-10-01 [PMID: 17878364] (Mouse)
• Fujita H, Asahina A, Komine M, Tamaki K The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells. Cell. Immunol., 2007-05-15;245(2):70-9. 2007-05-15 [PMID: 17507001] (Mouse)
• Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma. J. Immunol., 2007-05-15;178(10):6191-9. 2007-05-15 [PMID: 17475846] (Mouse)
• Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, Hogaboam CM Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am. J. Pathol., 2007-04-01;170(4):1152-64. 2007-04-01 [PMID: 17392156] (Mouse)
• Van Hove CL, Maes T, Joos GF, Tournoy KG Prolonged inhaled allergen exposure can induce persistent tolerance. Am. J. Respir. Cell Mol. Biol., 2007-01-11;36(5):573-84. 2007-01-11 [PMID: 17218615] (Mouse)
• Drmotova M, Rehnstrom E, Jansson L Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis. Cytokine, 2006-11-07;35(5):275-83. 2006-11-07 [PMID: 17088072] (Mouse)
• Tsunemi Y, Saeki H, Nakamura K, Nagakubo D, Nakayama T, Yoshie O, Kagami S, Shimazu K, Kadono T, Sugaya M, Komine M, Matsushima K, Tamaki K CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli. Eur. J. Immunol., 2006-08-01;36(8):2116-27. 2006-08-01 [PMID: 16856206] (Mouse)
• Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem. Biophys. Res. Commun., 2006-05-12;345(3):1122-30. 2006-05-12 [PMID: 16713992] (Mouse)
• Alvarez D, Swirski FK, Yang TC, Fattouh R, Croitoru K, Bramson JL, Stampfli MR, Jordana M Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues. J. Immunol., 2006-02-15;176(4):2568-80. 2006-02-15 [PMID: 16456019] (Mouse)

FAQs for CCL17/TARC (MCC170). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Ccl17