CXCR3 Antibody (220803) [Phycoerythrin]

Mouse splenocytes were stained with Rat Anti-Mouse CD3 APC-conjugated Monoclonal Antibody (Catalog # FAB4841A) and either (A) Rat Anti-Mouse CXCR3 PE-conjugated Monoclonal Antibody (Catalog # FAB1685P) or (B) Rat IgG2APhycoerythrin Isotype Control (Catalog # IC006P). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Mu
• Applications: Flow
• Clone: 220803
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Phycoerythrin

CXCR3 Antibody (220803) [Phycoerythrin] Summary

• Immunogen: CHO Chinese hamster ovary cell line transfected with mouse CXCR3
  Met1-Leu367
  Accession # AAC40163
• Specificity: Detects mouse CXCR3.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: CXCR3
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCR3 Antibody (220803) [Phycoerythrin]

• CD183 antigen
• CD183
• chemokine (C-X-C motif) receptor 3
• chemokine (C-X-C) receptor 3
• CKR-L2IP-10 receptor
• CMKAR3
• C-X-C chemokine receptor type 3
• CXCR3
• CXC-R3
• CXCR-3
• G protein-coupled receptor 9CD182
• GPR9
• GPR9Mig-R
• Interferon-inducible protein 10 receptor
• IP10 receptor
• IP10-R
• Mig receptor
• MigR

Background

CXCR3 is a G protein coupled chemokine receptor that binds the alpha chemokines MIG (CXCL9), IP-10 (CXCL10) and I-TAC (CXCL11). CXCR3 is expressed on activated T cells, B cells and NK cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CXCR3 Antibody (FAB1685P)(13)

Publications using FAB1685P

• Liza Lind, Alexandra Svensson, Karolina Thörn, Malgorzata Krzyzowska, Kristina Eriksson CD8+ T cells in the central nervous system of mice with herpes simplex infection are highly activated and express high levels of CCR5 and CXCR3 Journal of NeuroVirology 2021-02-01 [PMID: 33492607] (Flow Cytometry, Mouse)
• Liza Lind, Alexandra Svensson, Karolina Thörn, Malgorzata Krzyzowska, Kristina Eriksson CD8+ T cells in the central nervous system of mice with herpes simplex infection are highly activated and express high levels of CCR5 and CXCR3 Journal of NeuroVirology 2/1/2021 [PMID: 33492607]
• F Bian, Y Xiao, FL Barbosa, RG de Souza, H Hernandez, Z Yu, SC Pflugfelde, CS de Paiva Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells Mucosal Immunol, 2019-01-29;12(4):897-908. 2019-01-29 [PMID: 30696983] (Flow Cytometry, Mouse)
• Guiquan Zhu, H. Hannah Yan, Yanli Pang, Jiang Jian, Bhagelu R. Achyut, Xinhua Liang et al. CXCR3 as a molecular target in breast cancer metastasis: inhibition of tumor cell migration and promotion of host anti-tumor immunity Oncotarget 10/15/2015 [PMID: 26485767]
• Arieta Kuksin C, Gonzalez-Perez G, Minter L CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia. Blood, 2015-02-03;125(13):2087-94. 2015-02-03 [PMID: 25647836] (Flow Cytometry, Mouse)
• Marks BR, Nowyhed HN, Choi JY, Poholek AC, Odegard JM, Flavell RA, Craft J Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Nat. Immunol., 2009-09-06;10(10):1125-32. 2009-09-06 [PMID: 19734905] (Flow Cytometry, Mouse)
• Karagiannis ED, Popel AS A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc. Natl. Acad. Sci. U.S.A., 2008-09-09;105(37):13775-80. 2008-09-09 [PMID: 18780781] (Flow Cytometry, Human)
• Miyazaki Y, Shimanoe Y, Wang S, Yoshida H Amelioration of delayed-type hypersensitivity responses by IL-27 administration. Biochem. Biophys. Res. Commun., 2008-06-20;373(3):397-402. 2008-06-20 [PMID: 18572017] (Flow Cytometry, Mouse)
• Cox CA, Shi G, Yin H, Vistica BP, Wawrousek EF, Chan CC, Gery I Both Th1 and Th17 are immunopathogenic but differ in other key biological activities. J. Immunol., 2008-06-01;180(11):7414-22. 2008-06-01 [PMID: 18490741] (Flow Cytometry, Mouse)
• Calderon B, Suri A, Miller MJ Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules. Proc. Natl. Acad. Sci. U.S.A., 2008-04-21;105(16):6121-6. 2008-04-21 [PMID: 18427107] (Flow Cytometry, Mouse)
• de Jong EK, de Haas AH, Brouwer N, van Weering HR, Hensens M, Bechmann I, Pratley P, Wesseling E, Boddeke HW, Biber K Expression of CXCL4 in microglia in vitro and in vivo and its possible signaling through CXCR3. J. Neurochem., 2008-02-01;105(5):1726-36. 2008-02-01 [PMID: 18248618] (Flow Cytometry, Mouse)
• Horikawa M, Fujimoto M, Hasegawa M, Matsushita T, Hamaguchi Y, Kawasuji A, Matsushita Y, Fujita T, Ogawa F, Takehara K, Steeber DA, Sato S E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis. Am. J. Pathol., 2006-09-01;169(3):740-9. 2006-09-01 [PMID: 16936251] (Flow Cytometry, Mouse)
• Christensen JE, de Lemos C, Moos T, Christensen JP, Thomsen AR CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. J. Immunol., 2006-04-01;176(7):4235-43. 2006-04-01 [PMID: 16547260] (Flow Cytometry, Mouse)

Bioinformatics

• Gene Symbol: CXCR3
• Uniprot:
  • AAC40163()