CXCL12/SDF-1 Antibody (79018) [Unconjugated]

CXCL12/SDF-1 was detected in immersion fixed paraffin-embedded sections of human breast tumor using Mouse Anti-Human CXCL12/SDF-1, Monoclonal Antibody (Catalog #MAB350) at 15ug/mL at 37° Celsius for 4 minutes. Before incubation with the primary antibody, tissue underwent an all-in-one dewaxing and antigen retrieval preprocessing using PreTreatment Module (PT Module) and Dewax and HIER Buffer H (pH 9; Epredia Catalog # TA-999-DHBH). Tissue was stained using the Alexa Fluor™ 647 Goat anti-Mouse IgG Secondary Antibody at 1:200 at 37 ° Celsius for 2 minutes. (Yellow; Lunaphore Catalog # DR647MS) and counterstained with DAPI (blue; Lunaphore Catalog # DR100). Specific staining was localized to the cytoplasm. Protocol available in COMET™ Panel Builder.

CXCL12/SDF-1 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs; positive staining) and K562 human chronic myelogenous leukemia cell line (negative staining) using Mouse Anti-Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB350) at 8 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cell membranes. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

CXCL12/SDF‑1 was detected in immersion fixed paraffin-embedded sections of human tonsil using 15 µg/mL Human/Mouse CXCL12/SDF‑1 Monoclonal Antibody (Catalog # MAB350) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific labeling was localized to epithelial cells in cripts. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

CXCL12/SDF‑1 was detected in immersion fixed paraffin-embedded sections of human tonsil using Human/Mouse CXCL12/SDF‑1 Monoclonal Antibody (Catalog # MAB350) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

HT1080 human fibrosarcoma cell line was stained with Mouse Anti-Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB350, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). To facilitate intracellular staining, cells were fixed and permeabilized with FlowX FoxP3 Fixation & Permeabilization Buffer Kit (Catalog # FC012). View our protocol for Staining Intracellular Molecules.

CXCL12/SDF-1a mRNA was detected in formalin-fixed paraffin-embedded tissue sections of human tonsil probed with ACD RNAScope®Probe (Catalog # 422991) and stained using ACD RNAscope®2.5 HD Detection Reagents-Red (top image, Catalog # 32260). Adjacent tissue section was processed for immunohistochemistry using R&D Systems Mouse Anti-Human CXCL12/SDF-1a Monoclonal Antibody (Catalog # MAB350) at 5 ug/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte HRP Polymer Antibody (R&D Systems, Catalog # VC001) and DAB chromogen (lower image, yellow-brown). Tissues were counterstained with hematoxylin (blue).

CXCR4 and CXCL12 expression and BM infiltration. (a) Expression analysis of CXCR4 and CXCL12 in uninfiltrated and infiltrated bone marrow specimens at the time of diagnosis by RQ-PCR. (b) Expression analysis of CXCR4 and CXCL12 in infiltrated bone marrow biopsies and the respective paired sample in patients under remission by RQ-PCR. (c) Representative immunohistochemical stains of CXCR4 (I–II) and CXCL12 (III–IV) on selected bone marrow specimens of DLBCL patients (magnification 20×). (I) and (III) represent the CXCR4 and CXCL12 staining of uninfiltrated bone marrow specimens, and (II) and (IV) represent those of the infiltrated bone marrow specimens. mRNA expression levels were calculated as a relative expression in comparison to uninfiltrated bone marrow specimens. Each bar represents the mean values of expression levels ± standard error of the mean (SEM). The comparison of the expression levels was performed by using the Mann–Whitney U-test or the Student’s t-test. All images were captured using an Olympus BX51 microscope and an Olympus E-330 camera. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31554271), licensed under a CC-BY license. Not internally tested by R&D Systems.

RhoA modulates the CXCR4-CXCL12 axis in breast tumors. (a) Representative immunohistochemical (IHC) staining images of breast primary tumor sections of mice orthotopically injected with 4T1 GFP-LUC cells carrying indicated lentiviral modifications, stained with antibodies for CD31 (top, left), F4/80 (middle, left) and alpha -SMA (bottom, left). CD31+ area (top, right), F4/80+ cells (middle, right) and alpha -SMA+ area (bottom, right) per tumor field of view (FOV) (mean ± SE) quantifications of IHC images. N = 4. (b) Representative IHC staining images of breast primary tumor sections of above mice stained with CXCL12 antibody (left). CXCL12+ area per tumor FOV (mean ± SE) quantification of IHC images. N = 4. (c) Representative immunofluorescent images of breast primary tumor sections of above mice co-stained with alpha -SMA, CXCL12 and DRAQ5 nuclear stain, showing the co-localization of alpha -SMA and CXCL12 signals. Scale bar: 50 µm. (d) Representative IHC staining images of breast primary tumor sections of above mice stained with CXCR4 antibody (left). CXCR4+ area per tumor FOV (mean ± SE) quantification of IHC images. N = 4. (e) Relative mCXCR4 mRNA levels normalized with mActin (mean ± SE), as quantified by qRT-PCR in primary breast tumors of above mice (top) and in 4T1 GFP-LUC cells carrying indicated lentiviral modifications (bottom). N = 4, ns- not significant *P < 0.05, unpaired Student’s t-test (two-tailed). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31705019), licensed under a CC-BY license. Not internally tested by R&D Systems.

CXCR4 and CXCL12 expression in DLBCL. (a) Expression analysis of CXCR4 and CXCL12 in non-neoplastic control germinal center B cells (GC-B) and diffuse large B cell lymphoma cells (DLBCL) consisting of DLBCL-NGCB and DLCBL-GCB, by RQ-PCR. GCB-DLBCL were further subdivided into primary (DLBCL-pGCB) and transformed DLBCL (DLBCL-pGCB) originating from follicular lymphoma. (b) Expression analysis of CXCR4 and CXCL12 in DLBCL samples with early (stage 1) and advanced stage (stage 2–4) (left graphs) and DLBCL samples with and without bone marrow infiltration (right graphs) by RQ-PCR. (c) Probability of 5-year-survival in DLBCL patients (our cohort left panel and the cohort of Lenz et al. right [20]) stratified by the third quartile of CXCR4 expression, respectively. (d) Representative immunohistochemical stains of CXCR4 (I–III) and CXCL12 (IV–VI) on DLBCL samples (magnification 20×). mRNA expression levels were calculated as a relative expression in comparison to the GC-B cells. All images were captured using an Olympus BX51 microscope and an Olympus E-330 camera. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31554271), licensed under a CC-BY license. Not internally tested by R&D Systems.

Tumor-promoting phenotype of the myeloid clusters.IHC staining demonstrating the expression of CD163, IL-6, IL-10, VEGF-A, MMP-9, SDF-1 and Bcl-xL by the myeloid cells associated with anthracosis. For each protein, representative images showing positive and negative staining areas were selected from the same slide. The quantification was performed by analyzing random images of myeloid cluster areas associated with anthracosis and other areas (10 images for each group) from 10 patients. Two-tailed Student's t-test was used for statistical analysis. Shown are means ± SEM, *** P<0.001. (Scale bar, 200 µm for 100× and 400×; 25 µm for 1600×) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/23717691), licensed under a CC-BY license. Not internally tested by R&D Systems.

Afferent lymph vessels in chronically inflamed skin express CXCL12.Immunofluorescence staining of frozen sections of chronically inflamed skin (21 days after inflammation elicited by subcutaneous injection of CFA) for CXC12 and CCL21 by LYVE-1+ lymph vessels using DAPI counterstaining. One representative image of lymph vessels analyzed in 5 mice is shown. Scale bars, 10 µm. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/24752354), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Hu, Mu
• Applications: IHC, CyTOF-ready, Dual ISH-IHC, ELISA(Cap), Flow, ICC/IF, mIF
• Clone: 79018
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

CXCL12/SDF-1 Antibody (79018) [Unconjugated] Summary

• Immunogen: E. coli-derived recombinant human CXCL12/SDF‑1 alpha
  Lys22-Lys89
  Accession # Q6ICW0
• Specificity: Detects human and mouse CXCL12/SDF-1 alpha and CXCL12/SDF-1 beta in ELISAs.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CXCL12
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Dual RNAscope ISH-IHC 5-25 ug/mL
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • ELISA Standard (Matched Pair)
  • ELISA Standard (Matched Pair)
  • Immunocytochemistry 8-15 ug/mL
  • Immunohistochemistry 8-25 ug/mL
  • Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells
  • Multiplex Immunofluorescence 15 ug/mL
• Application Notes: ELISA Detection: Human/Mouse CXCL12/SDF-1 Biotinylated Antibody (Catalog number BAF310)
  Standard: Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF-1alpha (Catalog number 350-NS)
  Standard: Recombinant Mouse CXCL12/SDF-1alpha (Catalog number 460-SD) Use in ICC/IF reported in scientific literature (PMID:33435128)

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
  *Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL12/SDF-1 Antibody (79018) [Unconjugated]

• chemokine (C-X-C motif) ligand 12
• C-X-C motif chemokine 12
• CXCL12
• hIRH
• hSDF-1
• Intercrine reduced in hepatomas
• IRH
• PBSF
• PBSFSDF-1a
• Pre-B cell growth-stimulating factor
• SCYB12
• SDF1
• SDF-1
• SDF1A
• SDF1B
• SDF1SDF-1b
• stromal cell-derived factor 1
• TLSF
• TLSF-a
• TLSF-b
• TPAR1

Background

CXCL12, also known as SDF-1, is a CXC chemokine that interacts with CXCR4. SDF-1 alpha and SDF-1 beta are alternatively spliced isoforms of CXCL12. SDF-1 beta has an additional 4 amino acids at the carboxy-terminus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CXCL12/SDF-1 Antibody (MAB350)(163)

Publications using MAB350

• Camarano, J;Roque, M;Gahn, G;Whipple, SG;Terrell, D;Ronkon, C;Toms, J;Sin, A;Guthikonda, B;Latha, K;Yang, Y;Shen, X;Kevil, CG;Rao, G;Lee, S; Hydrogen sulfide inhibits recruitment of monocyte-derived tumor associated macrophages in glioblastoma by downregulating CXCL12 Redox biology 2025-10-01 [PMID: 40930029] (Immunohistochemistry, Human, Mouse)
• Makhijani, P;Valentino, TR;Manwaring-Mueller, M;Emani, R;Mu, WC;Aguirre, CG;Tan, CR;Rane, A;Wilson, KA;Kifle, A;Chen, N;Du, H;Wu, F;Ng, JHY;Ambrose, BD;Ashok Kumaar, PV;Khan, S;Winer, S;Wang, C;Mortha, A;Furman, D;Schilling, B;Ellerby, LM;Rojas, OL;Andersen, JK;Winer, DA; Amyloid-?-driven Alzheimer's disease reshapes the colonic immune system in mice Cell reports 2025-08-29 [PMID: 40885186] (Immunohistochemistry, Mouse)
• Donnelly, H;Ross, E;Xiao, Y;Hermantara, R;Taqi, AF;Doherty-Boyd, WS;Cassels, J;Tsimbouri, PM;Dunn, KM;Hay, J;Cheng, A;Meek, RMD;Jain, N;West, C;Wheadon, H;Michie, AM;Peault, B;West, AG;Salmeron-Sanchez, M;Dalby, MJ; Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells Nature communications 2024-07-10 [PMID: 38987295] (Immunocytochemistry, Human)
• Li, A;Yi, J;Li, X;Dong, L;Ostrow, LW;Ma, J;Zhou, J; Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice eLife 2024-04-25 [PMID: 38661532] (Immunohistochemistry, Mouse, Transgenic Mouse)
• Frenz-Wiessner, S;Fairley, SD;Buser, M;Goek, I;Salewskij, K;Jonsson, G;Illig, D;Zu Putlitz, B;Petersheim, D;Li, Y;Chen, PH;Kalauz, M;Conca, R;Sterr, M;Geuder, J;Mizoguchi, Y;Megens, RTA;Linder, MI;Kotlarz, D;Rudelius, M;Penninger, JM;Marr, C;Klein, C; Generation of complex bone marrow organoids from human induced pluripotent stem cells Nature methods 2024-02-19 [PMID: 38374263] (Immunohistochemistry, Human)
• Zheng, M;Kim, MH;Park, SG;Kim, WS;Oh, SH;Sung, JH; CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata International journal of molecular sciences 2024-01-30 [PMID: 38338982] (Immunohistochemistry, Mouse)
• Pu, T;Wang, J;Wei, J;Zeng, A;Zhang, J;Chen, J;Yin, L;Li, J;Lin, TP;Melamed, J;Corey, E;Gao, AC;Wu, BJ; Stromal-derived MAOB promotes prostate cancer growth and progression Science advances 2024-02-09 [PMID: 38335292] (Immunohistochemistry, Human, Xenograft)
• Nguyen, JN;Mohan, EC;Pandya, G;Ali, U;Tan, C;Kofler, JK;Shapiro, L;Marrelli, SP;Chauhan, A; CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery Journal of neuroinflammation 2023-10-10 [PMID: 37817190] (IHC, Human)
• Williamson, MR;Le, SP;Franzen, RL;Donlan, NA;Rosow, JL;Nicot-Cartsonis, MS;Cervantes, A;Deneen, B;Dunn, AK;Jones, TA;Drew, MR; Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke Nature communications 2023-10-10 [PMID: 37816732] (IHC, Transgenic Mouse)
• Chen S, Xing Z, Geng M et al. Macrophage fusion event as one prerequisite for inorganic nanoparticle-induced antitumor response Science advances 7/21/2023 [PMID: 37467339]
• Ayano KUDO, Hiroki SAWAHATA, Sho YOSHIMOTO, Akinori YAMAUCHI, Ryo OSHITA, Eiichi KANAI et al. Evaluation of the influence of the C-X-C motif chemokine ligand 12 / C-X-C chemokine receptor 4 axis on canine mammary gland tumor cell migration Journal of Veterinary Medical Science 2023-08-01 [PMID: 37302847] (Immunohistochemistry, Canine)
• Ayano KUDO, Hiroki SAWAHATA, Sho YOSHIMOTO, Akinori YAMAUCHI, Ryo OSHITA, Eiichi KANAI et al. Evaluation of the influence of the C-X-C motif chemokine ligand 12 / C-X-C chemokine receptor 4 axis on canine mammary gland tumor cell migration Journal of Veterinary Medical Science 8/1/2023 [PMID: 37302847]
• PK Suvas, M Setia, M Rana, A Chakrabort, S Suvas Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas The ocular surface, 2023;28(0):99-107. 2023 [PMID: 36813133] (IHC, Mouse)
• PK Suvas, M Setia, M Rana, A Chakrabort, S Suvas Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas The ocular surface, 2023-02-20;28(0):99-107. 2023-02-20 [PMID: 36813133] (IHC, Mouse)
• Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko et al. Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton bioRxiv 5/7/2023 [PMID: 36711531]
• Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko et al. Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton bioRxiv 2023-05-07 [PMID: 36711531] (CyTof, Mouse)
• F Lunardi, DI Abbrescia, L Vedovelli, F Pezzuto, F Fortarezza, GM Comacchio, V Guzzardo, P Ferrigno, M Loy, C Giraudo, AS Fraia, E Faccioli, F Braccioni, E Cozzi, D Gregori, GM Verleden, F Calabrese, FP Schena, F Rea Molecular Profiling of Tissue Samples with Chronic Rejection from Patients with Chronic Lung Allograft Dysfunction: A Pilot Study in Cystic Fibrosis Patients Biomolecules, 2023-01-03;13(1):. 2023-01-03 [PMID: 36671482] (IHC, Human)
• C D'Alterio, A Giardino, G Scognamigl, G Butturini, L Portella, G Guardascio, I Frigerio, M Montella, S Gobbo, G Martignoni, V Napolitano, F De Vita, F Tatangelo, R Franco, S Scala CXCR4-CXCL12-CXCR7 and PD-1/PD-L1 in Pancreatic Cancer: CXCL12 Predicts Survival of Radically Resected Patients Cells, 2022-10-22;11(21):. 2022-10-22 [PMID: 36359736] (IHC, Human)
• Pernilla Wikström, Sofia Halin Bergström, Andreas Josefsson, Julius Semenas, Annika Nordstrand, Elin Thysell et al. Epithelial and Stromal Characteristics of Primary Tumors Predict the Bone Metastatic Subtype of Prostate Cancer and Patient Survival after Androgen-Deprivation Therapy Cancers (Basel) 10/23/2022 [PMID: 36358614]
• Tobias Petzold, Zhe Zhang, Iván Ballesteros, Inas Saleh, Amin Polzin, Manuela Thienel et al. Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease Immunity 2022-12-13 [PMID: 36272416] (Immunohistochemistry, Transgenic Mouse)
• Tobias Petzold, Zhe Zhang, Iván Ballesteros, Inas Saleh, Amin Polzin, Manuela Thienel et al. Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease Immunity 12/13/2022 [PMID: 36272416]
• Irene Mariam Roy, P.V. Anu, Samantha Zaunz, Srinu Reddi, Aravind M. Giri, Rithika Saroj Sankar et al. Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function iScience 10/21/2022 [PMID: 36204266]
• YW Dai, JK Ma, R Jiang, XL Zhan, SY Chen, LL Feng, Q Zhang, TB Liang, K Lv, GJ Yang, JF Lu, J Chen, XJ Lu Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization Cell Reports, 2022-09-20;40(12):111361. 2022-09-20 [PMID: 36130501] (ELISA Capture, Mouse)
• Jacob C. Holter, Chia-Wen Chang, Alex Avendano, Ayush A. Garg, Ajeet K. Verma, Manish Charan et al. Fibroblast-derived CXCL12 increases vascular permeability in a 3-D microfluidic model independent of extracellular matrix contractility Frontiers in Bioengineering and Biotechnology 2022-09-02 [PMID: 36118583] (Immunocytochemistry, Mouse)
• Jacob C. Holter, Chia-Wen Chang, Alex Avendano, Ayush A. Garg, Ajeet K. Verma, Manish Charan et al. Fibroblast-derived CXCL12 increases vascular permeability in a 3-D microfluidic model independent of extracellular matrix contractility Frontiers in Bioengineering and Biotechnology 9/2/2022 [PMID: 36118583]
• CC Liu, J Zhao, Y Fu, Y Inoue, Y Ren, Y Chen, SV Doss, F Shue, S Jeevaratna, L Bastea, N Wang, YA Martens, W Qiao, M Wang, N Zhao, L Jia, Y Yamazaki, A Yamazaki, CL Rosenberg, Z Wang, D Kong, Z Li, LA Kuchenbeck, ZA Trottier, L Felton, J Rogers, ZS Quicksall, C Linares, J Knight, Y Chen, A Kurti, T Kanekiyo, JD Fryer, YW Asmann, P Storz, X Wang, J Peng, B Zhang, BYS Kim, G Bu Peripheral apoE4 enhances Alzheimer&#039;s pathology and impairs cognition by compromising cerebrovascular function Nature Neuroscience, 2022-08-01;25(8):1020-1033. 2022-08-01 [PMID: 35915180] (IHC, Mouse)
• II Verginadis, H Avgousti, J Monslow, G Skoufos, F Chinga, K Kim, NM Leli, IV Karagounis, BI Bell, A Velalopoul, CS Salinas, VS Wu, Y Li, J Ye, DA Scott, AL Osterman, A Sengupta, A Weljie, M Huang, D Zhang, Y Fan, E Radaelli, JW Tobias, F Rambow, P Karras, JC Marine, X Xu, AG Hatzigeorg, S Ryeom, JA Diehl, SY Fuchs, E Puré, C Koumenis A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression Nature Cell Biology, 2022-06-02;0(0):. 2022-06-02 [PMID: 35654839] (IHC, Mouse)
• C D'Alterio, A Spina, L Arenare, P Chiodini, M Napolitano, F Galdiero, L Portella, V Simeon, S Signoriell, F Raspaglies, D Lorusso, C Pisano, N Colombo, GF Zannoni, NS Losito, R De Cecio, G Scognamigl, D Califano, D Russo, V Tuninetti, MC Piccirillo, P Gargiulo, F Perrone, S Pignata, S Scala Biological Role of Tumor/Stromal CXCR4-CXCL12-CXCR7 in MITO16A/MaNGO-OV2 Advanced Ovarian Cancer Patients Cancers, 2022-04-06;14(7):. 2022-04-06 [PMID: 35406620] (IHC, Human)
• AR Pereira, D Trivanovi?, P Stahlhut, M Rudert, J Groll, M Herrmann Preservation of the na�ve features of mesenchymal stromal cells in vitro: Comparison of cell- and bone-derived decellularized extracellular matrix Journal of tissue engineering, 2022-02-07;13(0):2041731422107. 2022-02-07 [PMID: 35154631] (ICC, Human)
• C Fielding, A García-Gar, C Korn, S Gadomski, Z Fang, JL Reguera, JA Pérez-Simó, B Göttgens, S Méndez-Fer Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis Nature Communications, 2022-01-27;13(1):543. 2022-01-27 [PMID: 35087060] (ELISA Capture, Mouse)
• Jiang Z, Li H, Schroer SA et al. Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes The EMBO journal 1/13/2022 [PMID: 35023164]
• G Cantini, L Fei, L Canu, E Lazzeri, M Sottili, M Francalanc, ML Angelotti, G De Filpo, T Ercolino, S Gelmini, M Mangoni, G Nesi, C Hantel, M Mannelli, M Maggi, M Luconi Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression Journal of personalized medicine, 2021-10-27;11(11):. 2021-10-27 [PMID: 34834449] (IHC, Human)
• YS Lee, TY Kim, Y Kim, S Kim, SH Lee, SU Seo, BO Zhou, O Eunju, KS Kim, MN Kweon Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells Experimental & Molecular Medicine, 2021-09-09;0(0):. 2021-09-09 [PMID: 34497346] (ICC, IHC, Mouse)
• Lucia Suarez-Lopez, Yi Wen Kong, Ganapathy Sriram, Jesse C. Patterson, Samantha Rosenberg, Sandra Morandell et al. MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer Frontiers in Immunology 2/23/2021 [PMID: 33708191]
• Alan Bénard, Anne Jacobsen, Maximilian Brunner, Christian Krautz, Bettina Klösch, Izabela Swierzy et al. Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections Nature Communications 2/18/2021 [PMID: 33602937]
• Z Benet, Z Jing, DR Fooksman Plasma cell dynamics in the bone marrow niche Cell Reports, 2021-02-09;34(6):108733. 2021-02-09 [PMID: 33567286] (ELISA Development, Mouse)
• J Kim, SW Lee, K Park CXCR4 Regulates Temporal Differentiation via PRC1 Complex in Organogenesis of Epithelial Glands International Journal of Molecular Sciences, 2021-01-10;22(2):. 1/10/2021 [PMID: 33435128]
• Masakazu Yashiro, Haruhito Kinoshita, Gen Tsujio, Tatsunari Fukuoka, Yurie Yamamoto, Tomohiro Sera et al. SDF1&alpha;/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment Oncology Letters 2020-11-12 [PMID: 33262830] (Immunohistochemistry, Human)
• Masakazu Yashiro, Haruhito Kinoshita, Gen Tsujio, Tatsunari Fukuoka, Yurie Yamamoto, Tomohiro Sera et al. SDF1&alpha;/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment Oncology Letters 11/12/2020 [PMID: 33262830]
• D Biasci, M Smoragiewi, CM Connell, Z Wang, Y Gao, JED Thaventhir, B Basu, L Magiera, TI Johnson, L Bax, A Gopinathan, C Isherwood, FA Gallagher, M Pawula, I Hudecova, D Gale, N Rosenfeld, P Barmpounak, EC Popa, R Brais, E Godfrey, F Mir, FM Richards, DT Fearon, T Janowitz, DI Jodrell CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response Proc Natl Acad Sci U S A, 2020-10-30;0(0):. 2020-10-30 [PMID: 33127761] (IHC, Human)
• C D'Alterio, A Zannetti, AM Trotta, C Ieranò, M Napolitano, G Rea, A Greco, P Maiolino, S Albanese, G Scognamigl, F Tatangelo, S Tafuto, L Portella, S Santagata, G Nasti, A Ottaiano, R Pacelli, P Delrio, G Botti, S Scala New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer Cancers (Basel), 2020-07-18;12(7):. 2020-07-18 [PMID: 32708431] (IHC, Mouse)
• R Dong, Y Bai, J Dai, M Deng, C Zhao, Z Tian, F Zeng, W Liang, L Liu, S Dong Engineered scaffolds based on mesenchymal stem cells/preosteoclasts extracellular matrix promote bone regeneration J Tissue Eng, 2020-06-07;11(0):2041731420926. 2020-06-07 [PMID: 32551034] (Neutralization, Mouse)
• CN Tsai, SC Yu, CW Lee, JS Pang, CH Wu, SE Lin, YH Chung, CL Tsai, SY Hsieh, MC Yu SOX4 activates CXCL12 in hepatocellular carcinoma cells to modulate endothelial cell migration and angiogenesis in vivo Oncogene, 2020-05-13;0(0):. 2020-05-13 [PMID: 32404985] (Functional Assay, Human)
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Review for CXCL12/SDF-1 Antibody (MAB350) (1)

Average Rating: 4

(Based on 1 review)

We have 1 review tested in 1 species: Mouse.

reviewed by: Kirsten Hattermann-Koch IHC-Fr Mouse 04/18/2019

Summary

• Application: Immunohistochemistry-Frozen
• Sample Tested: Adult brain
• Species: Mouse
• Lot: COJ0518011

Bioinformatics

• Gene Symbol: CXCL12
• Uniprot:
  • Q6ICW0()