IHC, ELISA(Cap), ICFlowHost:
The C-X-C or alpha chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell-derived factor-1, or SDF-1. SDF-1 was originally described as a pre-B cell stimulatory factor, but has now been shown to function as a potent chemoattractant for T cells and monocytes, but not neutrophils. Receptors for the C-X-C family are G protein-coupled, seven-pass, transmembrane domain proteins which include IL-8RA, IL-8RB and fusin (also designated LESTR or CXCR-4). Fusin is highly homologous to the IL-8 receptors, sharing 37% sequence identity at the amino acid level. The IL-8 receptors bind to IL-8, NAP-2 and MSGA, while fusin binds to its cognate ligand, SDF-1. Fusin has been identified as the major co-receptor for T-tropic HIV-1, and SDF-1 has been shown to inhibit HIV-1 infection. Six human SDF-1 isoforms exist due to alternative splicing of CXCL12, the gene encoding SDF-1. Three isoforms are known for mouse and rat.
|Product By Gene ID
- C-X-C motif chemokine 12
- Pre-B cell growth-stimulating factor
- Intercrine reduced in hepatomas
- stromal cell-derived factor 1
- chemokine (C-X-C motif) ligand 12
Bioinformatics Tool for CXCL12/SDF-1
Discover related pathways, diseases and genes to CXCL12/SDF-1. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.