CXCL13/BLC/BCA-1 Antibody


CXCL13/BLC/BCA‑1 was detected in perfusion fixed frozen sections of mouse intestine (Peyer's patch) using Goat Anti-Mouse CXCL13/BLC/BCA‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF470) at 15 µg/mL more
Recombinant Mouse CXCL13/BLC/BCA‑1 (Catalog # 470-BC) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR5 in a dose-dependent manner (orange line). The amount of cells that migrated through to more

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Reactivity MuSpecies Glossary
Applications WB, IHC, B/N

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CXCL13/BLC/BCA-1 Antibody Summary

E. coli-derived recombinant mouse CXCL13/BLC/BCA‑1
Accession # Q3U1E8
Detects mouse CXCL13/BLC/BCA‑1 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) CXCL13 and rhGCP-2 is observed.
Immunogen affinity purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 0.1 ug/mL
  • Immunohistochemistry 5-15 ug/mL
  • Neutralization 20-50 ug/mL
Read Publications using
AF470 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
No Preservative
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL13/BLC/BCA-1 Antibody

  • ANGIE2
  • B cell-attracting chemokine 1
  • B lymphocyte chemoattractant
  • BCA1
  • BCA-1
  • BCA1B-cell chemoattractant
  • BCA-1CXC chemokine BLC
  • B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)
  • BLC
  • BLCSmall-inducible cytokine B13
  • BLR1L
  • B-lymphocyte chemoattractant
  • chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
  • chemokine (C-X-C motif) ligand 13
  • C-X-C motif chemokine 13
  • CXCL13
  • SCYB13B-cell-attracting chemokine 1
  • small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)


CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Mouse BCA-1 cDNA encodes a precursor protein of 109 amino acid residues with a putative leader sequence of 21 residues. Mature mouse BCA-1 shares 64% amino acid sequence similarity with the human protein and 23‑34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA-1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA-1. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas.

  1. Gunn, M.D. et al. (1998) Nature, 391:799.
  2. Legler, D.F. et al. (1998) J. Exp. Med. 187:655.
  3. Forster, R. et al. (1996) Cell 87:1037.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CXCL13/BLC/BCA-1 Antibody (AF470)(23)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 12 applications: Flow, ICC, IHC, IHC - Frozen, IHC Fresh, IHC Frozen, IHC Paraffin-embedded, IHC- Fresh Frozen, IHC-F, IHC-Fr, Neut, Western Blot.

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Showing Publications 1 - 10 of 23. Show All 23 Publications.
Publications using AF470 Applications Species
D Respatika, Y Saito, K Washio, S Komori, T Kotani, H Okazawa, Y Murata, T Matozaki Role of SIRP? in Homeostatic Regulation of T Cells and Fibroblastic Reticular Cells in the Spleen Kobe J Med Sci, 2017;63(1):E22-E29. 2017 [PMID: 29434170] (IHC-F,, Mouse) IHC-F Mouse
DT Mzinza, H Fleige, K Laarmann, S Willenzon, J Ristenpart, J Spanier, G Sutter, U Kalinke, P Valentin-W, R Förster Application of light sheet microscopy for qualitative and quantitative analysis of bronchus-associated lymphoid tissue in mice Cell. Mol. Immunol., 2018;0(0):. 2018 [PMID: 29429996] (IHC- Fresh Frozen,, Mouse) IHC- Fresh Frozen Mouse
W Alturaiki, AJ McFarlane, K Rose, R Corkhill, PS McNamara, J Schwarze, BF Flanagan Expression of the B cell differentiation factor BAFF and chemokine CXCL13 in a murine model of Respiratory Syncytial Virus infection Cytokine, 2018;0(0):. 2018 [PMID: 29396045] (IHC-Fr,, Mouse) IHC-Fr Mouse
VM Turner, NA Mabbott Ageing adversely affects the migration and function of marginal zone B cells Immunology, 2017;151(3):349-362. 2017 [PMID: 28369800] (IHC-Fr,, Mouse) IHC-Fr Mouse
T Eddens, W Elsegeiny, ML Garcia-Her, P Castillo, G Trevejo-Nu, K Serody, BT Campfield, SA Khader, K Chen, J Rangel-Mor, JK Kolls Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity Cell Rep, 2017;18(13):3078-3090. 2017 [PMID: 28355561] (IHC,, Mouse) IHC Mouse
Brain inflammation is accompanied by peripheral inflammation in Cstb (-/-) mice, a model for progressive myoclonus epilepsy J Neuroinflammation, 2016;13(1):298. 2016 [PMID: 27894304] (IHC - Frozen,, Mouse) IHC - Frozen Mouse
Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia Cancer Discov, 2016;6(3):256-69. 2016 [PMID: 26715642] (Western Blot,, Mouse) Western Blot Mouse
Buettner M, Dittrich-Breiholz O, Falk C, Lochner M, Smoczek A, Menzel F, Bornemann M, Bode U Stromal cells as trend-setters for cells migrating into the lymph node. Mucosal Immunol, 2015;8(3):640-9. 2015 [PMID: 25354321] (IHC Frozen,, Mouse) IHC Frozen Mouse
Fleige H, Ravens S, Moschovakis G, Bolter J, Willenzon S, Sutter G, Haussler S, Kalinke U, Prinz I, Forster R IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med, 2014;211(4):643-51. 2014 [PMID: 24663215] (IHC,, Mouse) IHC Mouse
Yamamoto, K, Nishiumi, S, Yang, L, Klimatcheva, E, Pandina, T, Takahashi, S, Matsui, H, Nakamura, M, Zauderer, M, Yoshida, M, Azuma, T Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection. Mucosal Immunol, 2014;7(5):1244-54. 2014 [PMID: 24646940] (Neut,, Mouse) Neut Mouse
Show All 23 Publications.

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Gene Symbol CXCL13