DPPIV/CD26 Antibody [Unconjugated] Summary
Mouse myeloma cell line NS0-derived recombinant human DPPIV/CD26 (Catalog # 1180-SE
Accession # Q53TN1
Detects human DPPIV/CD26 in direct ELISAs and Western blots.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Immunocytochemistry 1-15 ug/mL
- Immunohistochemistry 1-15 ug/mL
- Simple Western 2 ug/mL
- Western Blot 0.2 ug/mL
Packaging, Storage & Formulations
|Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for DPPIV/CD26 Antibody [Unconjugated]
- ADCP2DPP IV
- Adenosine deaminase complexing protein 2TP103
- CD26 antigen
- CD26T-cell activation antigen CD26
- dipeptidyl peptidase 4
- Dipeptidyl peptidase IV
- dipeptidylpeptidase 4
- dipeptidyl-peptidase 4
- dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
- EC 18.104.22.168
DPPIV/CD26 (EC 22.214.171.124) is a serine exopeptidase that releases Xaa-Pro dipeptides from the N-terminus of oligo- and polypeptides. It is a type II membrane protein consisting of a short cytoplasmic tail, a transmembrane domain, and a long extracellular domain. The extracellular domain contains glycosylation sites, a cysteine-rich region and the catalytic active site (Ser, Asp and His charge relay system). The amino acid sequence of the mouse DPPIV/CD26 extracellular domain is 84% and 91% identical to the human and rat counterparts, respectively. In the native state, DPPIV/CD26 is present as a noncovalently linked homodimer on the cell surface of a variety of cell types. The soluble form is also detectable in human serum and other body fluids, the levels of which may have clinical significance in patients with cancer, liver and kidney diseases, and depression.
DPPIV/CD26 plays an important role in many biological and pathological processes. It functions as T cell-activating molecule (THAM). It serves as a cofactor for entry of HIV in CD4+ cells. It binds adenosine deaminase, the deficiency of which causes severe combined immunodeficiency disease in humans. It cleaves chemokines such as stromal-cell-derived factor 1 alpha and macrophage-derived chemokine. It degrades peptide hormones such as glucagon. It truncates procalcitonin, a marker for systemic bacterial infections with elevated levels detected in patients with thermal injury, sepsis and severe infection, and in children with bacterial meningitis.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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