CTLA-4 Antibody (L4P2F5*F10) Summary
Ovalbumin-conjugated synthetic peptide CENAPNRARM
Protein G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Western Blot 1:100 - 1:2000
- ELISA 1:100 - 1:2000
- Immunohistochemistry 1:10 - 1:500
Immunogen sequence is identical to mouse (Mus musculus), rat (Rattus norvegicus) and bovine (Bos taurus).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
Protein G purified
Positive control(s): IHC- formalin-fixed, paraffin-embedded multi tumour tissue microarray; WB - Jurkat cell lysates.
Alternate Names for CTLA-4 Antibody (L4P2F5*F10)
- CD152 antigen
- celiac disease 3
- cytotoxic T-lymphocyte antigen 4
- cytotoxic T-lymphocyte protein 4
- Cytotoxic T-lymphocyte-associated antigen 4
- cytotoxic T-lymphocyte-associated protein 4
- cytotoxic T-lymphocyte-associated serine esterase-4
- ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein that plays an important regulatory role in the immune system. CTLA4 is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. Mutations in the CTLA4 gene have been associated with various autoimmune diseases, such as systemic lupus erythematosus, insulin-dependent diabetes mellitus, and other autoimmune diseases. A recently identified novel transcript of the CTLA-4 gene that may represent a native soluble form of CTLA-4 (sCTLA-4) showed that eleven of twenty patients with autoimmune thyroid disease (ATD ) had a high concentration of sCTLA-4, whereas only 1 of 30 apparently healthy volunteers contained measurable levels. sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. sCTLA4 also plays a role in the initial immune response to infection of immune cells by HIV, along with the CD-1 pathway and others.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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