CTLA-4 Antibody (L4P2F5*F10)

Images

 
Western Blot: CTLA-4 Antibody (L4P2F5/F10) [NBP2-50286] - Analysis of CTLA-4 in Jurkat cell lysates. Two products are detected, slightly larger than anticipated-possibly due to glycosylation.
Immunohistochemistry: CTLA-4 Antibody (L4P2F5/F10) [NBP2-50286] - Staining of a paraffin-embedded human lymph node cross section. Cytoplasmic staining is shown as expected (CTLA4 is expressed in T-cells). B. Positive ...read more
ELISA: CTLA-4 Antibody (L4P2F5/F10) [NBP2-50286] - Detection of soluble CTLA4 in mouse serum by indirect ELISA.

Product Details

Summary
Reactivity Hu, Mu, Rt, BvSpecies Glossary
Applications WB, ELISA, IHC
Clone
L4P2F5*F10
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

CTLA-4 Antibody (L4P2F5*F10) Summary

Immunogen
Ovalbumin-conjugated synthetic peptide CENAPNRARM
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CTLA4
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100 - 1:2000
  • ELISA 1:100 - 1:2000
  • Immunohistochemistry 1:10 - 1:500

Reactivity Notes

Immunogen sequence is identical to mouse (Mus musculus), rat (Rattus norvegicus) and bovine (Bos taurus).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Protein G purified

Notes

Positive control(s): IHC- formalin-fixed, paraffin-embedded multi tumour tissue microarray; WB - Jurkat cell lysates.

Alternate Names for CTLA-4 Antibody (L4P2F5*F10)

  • CD
  • CD152 antigen
  • CD152
  • CD152IDDM12
  • CD28
  • celiac disease 3
  • CELIAC3
  • CTLA4
  • CTLA-4
  • cytotoxic T-lymphocyte antigen 4
  • cytotoxic T-lymphocyte protein 4
  • Cytotoxic T-lymphocyte-associated antigen 4
  • cytotoxic T-lymphocyte-associated protein 4
  • cytotoxic T-lymphocyte-associated serine esterase-4
  • GRD4
  • GSE
  • ICOS
  • ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

Background

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein that plays an important regulatory role in the immune system. CTLA4 is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. Mutations in the CTLA4 gene have been associated with various autoimmune diseases, such as systemic lupus erythematosus, insulin-dependent diabetes mellitus, and other autoimmune diseases. A recently identified novel transcript of the CTLA-4 gene that may represent a native soluble form of CTLA-4 (sCTLA-4) showed that eleven of twenty patients with autoimmune thyroid disease (ATD ) had a high concentration of sCTLA-4, whereas only 1 of 30 apparently healthy volunteers contained measurable levels. sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. sCTLA4 also plays a role in the initial immune response to infection of immune cells by HIV, along with the CD-1 pathway and others.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Here at Bio-Techne we always look forward to the annual announcements of winners of the highly coveted Nobel Prize – the greatest award in science. How can you go about predicting which scientists might be in line for a life-changing phone-call fro...  Read full blog post.

CD86 - I work in tandem with CD80
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Bioinformatics

Gene Symbol CTLA4