Complement Factor B Antibody (014III-22.214.171.124) Summary
Purified human complement factor b
NB100-64343 recognizes the 30kDa Ba fragment of 90kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit), leaving the 63 kDa Bb subunit associated with C3b, forming C3 convertase. Subunit Ba inhibits lymphocyte proliferation. Conversely, subunit Bb is involved in the proliferation of preactivated B lymphocytes. NB100-64343 inhibits the function of factor B and binds both nascent factor B and the Ba cleavage product. Removal of Sodium Azide is recommended prior to use in functional assays.
Protein A purified
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- Western Blot 1:100-1:2000
- ELISA 1:100-1:2000
- Flow Cytometry 1:10-1:1000
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Frozen 1:10-1:500
Cone 014III126.96.36.199 binds both the Ba fragment and the whole protein so is not suitable for all ELISA applications.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Borate buffered saline
0.1% Sodium Azide
Protein A purified
Alternate Names for Complement Factor B Antibody (014III-188.8.131.52)
- B-factor, properdin
- C3 proaccelerator
- C3 proactivator
- C3/C5 convertase
- Complement Factor B
- EC 3.4.21
- EC 184.108.40.206
- Glycine-rich beta glycoprotein
- glycine-rich beta-glycoprotein
- Properdin factor B
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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